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Composition for wound protection and dressing formed by composition

A composition and wound technology, applied in the medical field, can solve problems such as irritation of the wound, tearing of the epidermis, inability to disinfect and sterilize the wound, etc., to prevent secondary infection and damage, low solvent residue, and conducive to repair. Effect

Active Publication Date: 2017-04-19
JIANG SU PHARMAMAXCORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the products used for wound care in the medical field, such as various band-aids, have the advantages of low price and convenient use, but there are also some defects in use: the water absorption and ventilation of the band-aid itself are poor, which is not conducive to the wound The drainage of secretions is conducive to the growth and reproduction of bacteria, making the wound and the surrounding skin white and soft, resulting in secondary infection
Moreover, when the Band-Aid is torn off from the wound, the new epidermis will be torn apart due to the pressure-sensitive adhesive on it, causing the patient to feel pain.
[0004] There are many deficiencies in the existing band-aids on the market, which cannot disinfect and sterilize the wound, and are easy to breed germs
Most of the existing liquid wound protection products contain unpleasant odors, cannot guarantee sterility, have no killing effect on wound bacteria, and cannot prevent secondary infection of wounds
Most of these products are difficult to form an effective application to protect the wound
Some medicine-containing products are irritating to wounds, especially those containing antibiotics are likely to cause allergic reactions in the human body, and their application is limited
[0005] Chinese patent CN201210283814.1 improves the existing film-forming technology, and discloses a wound spray for treating abrasions and its preparation method. This patent has the following disadvantages: when the spray contacts with the wound, it will Painful; longer wound healing time; prone to scarring after wound healing

Method used

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  • Composition for wound protection and dressing formed by composition
  • Composition for wound protection and dressing formed by composition
  • Composition for wound protection and dressing formed by composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] The components and proportioning of the wound protection composition of the present embodiment are as follows:

[0070] components weight percentage Acrylic resin-polyvinyl butyral (weight ratio 1:7) 8％ Sodium pyruvate-dipotassium glycyrrhizinate (3:1 by weight) 4％ Ethanol-Benzalkonium Chloride (80:1 by weight) 75％ water 8％ ethyl oleate 4％ Menthol 1％

[0071] Preparation:

[0072] 1) Add 40g of acrylic resin-polyvinyl butyral mixture into 40g of water, heat to 70°C until completely dissolved and then cool;

[0073] 2) Add 20 g of sodium pyruvate-dipotassium glycyrrhizinate mixture into 1), and stir until completely dissolved;

[0074] 3) Add 20g of ethyl oleate and 5g of menthol to 375g of ethanol-benzalkonium chloride;

[0075] 4) fully mix the solutions of steps 2) and 3) evenly;

[0076] 5) Sterilize and fill to obtain the wound protection composition of the present invention.

Embodiment 2-43

[0078] The compositions in Examples 2-43 were prepared by the same preparation method as in Example 1, except that the components and contents used were different. Each component and its content and weight ratio are shown in the following table in the embodiment 2-43:

[0079]

[0080]

[0081]

[0082] Experimental part

experiment example 1

[0084] Adopt the wound protection composition of embodiment 25 to carry out the gas permeability test of application for test object

[0085] Application and film formation method: Prepare a circular plastic or glass petri dish with a diameter of 9cm, add the corresponding gram sample on the surface of the petri dish, and smooth it with a brush or glass rod to make it evenly cover the petri dish, and place it Put it into a drug stabilization box at 32°C, place it at a constant temperature for 15 minutes, and then take it out for use.

[0086] Test method: Put the above-mentioned applied film into a medicine temperature box with a temperature of 25°C and a humidity of 60%RH, and leave it for 16 hours before taking it out. Take a certain number of PE plastic vials, fill them with water to the mouth of the bottle, seal the mouth of the bottle with an applicator film formed by the material liquid, tie it tightly with hemp rope or rubber bands to make it sealed, weigh them one by o...

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Abstract

The invention provides a wound protection composition, which is capable of preventing wound infection and promoting injury repair. The composition is free from antibiotics, and the composition consists of a dressing tenacity enhancing component, cell injury repair factors, a bactericidal-bacteriostatic molecule pair and a solvent. The composition can form a transparent liquid layer on the outer surface of a wound, and the transparent liquid layer can be rapidly transformed into a dressing which is thinner than 0.01mm. The composition is capable of forming a film easily and the film material is high in tenacity, and the dressing, which is formed on the outer surface of the wound, is high in air permeability and waterproof performance and is capable of effectively preventing such foreign matters as bacteria, dust and the like from invading into the wound so as to prevent infections; meanwhile, the dressing has such effects as killing bacteria, stopping bleeding, relieving pain and the like; and the composition is free from sensitization and hormone, and the composition is capable of effectively promoting the repair of damaged cells and wounds.

Description

technical field [0001] The invention relates to the field of medical technology. Specifically, the present invention provides a wound protection composition that prevents wound infection and promotes damage repair, forms a transparent liquid layer on the outer surface of the wound, and quickly converts into a transparent application, and the application formed on the outer surface of the wound has air permeability , High waterproof performance, can effectively block foreign matter such as bacteria and dust from invading the wound, and avoid re-infection of the wound. Background technique [0002] Abrasions and superficial cuts are a very common type of trauma. They are prone to abrasions when slipping or falling, and are prone to cuts when cut by sharp objects such as paper and knives. The wounds vary in size and shape. After the skin epidermis is damaged, the wound surface appears pale, and there are many small bleeding spots and tissue fluid exudation, and some wounds can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K9/70A61K9/12A61K47/32A61K47/14A61K47/10A61K47/34A61K47/22A61K47/36A61P17/02A61P31/04A61P31/00
Inventor 蒋志君汪磊吴琛
Owner JIANG SU PHARMAMAXCORP
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