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Molybdenum disulfide/gold nanoparticle mixed structure biosensor material and preparation method thereof

A biosensor and gold nanoparticle technology, which is applied in the fields of material analysis, material excitation analysis, and material analysis through optical means, can solve the problems of difficult detection of mixed biomolecules and low sensitivity of biosensors, and achieve separation and detection, The method is simple and controllable, and the effect of low cost

Active Publication Date: 2017-03-22
SHANDONG NORMAL UNIV
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  • Application Information

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Problems solved by technology

[0007] In order to solve the shortcomings of current biosensors such as low sensitivity and difficulty in detecting mixed biomolecules, an object of the present invention is to provide a biosensor material with a molybdenum disulfide / gold nanoparticle hybrid structure, which is deposited on a three-dimensional glass fiber Two-dimensional molybdenum disulfide, prepared by growing gold particles on a glass fiber substrate with molybdenum disulfide attached, can separate a mixture of various biomolecules and chemically enhance each biomolecule, Improve the accuracy of each biomolecule assay

Method used

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  • Molybdenum disulfide/gold nanoparticle mixed structure biosensor material and preparation method thereof
  • Molybdenum disulfide/gold nanoparticle mixed structure biosensor material and preparation method thereof
  • Molybdenum disulfide/gold nanoparticle mixed structure biosensor material and preparation method thereof

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Embodiment 1

[0075] Prepare biosensor materials with molybdenum disulfide / gold nanoparticle hybrid structure on three-dimensional three-dimensional glass fiber paper, such as Figure 5 The preparation roadmap includes the following preparation steps:

[0076] 1. Prepare an ammonium tetrathiomolybdate solution with a concentration of 0.01g / ml, and pour an appropriate amount of ammonium tetrathiomolybdate solution into a glass dish.

[0077] 2. Take fiberglass paper with a size of 7cm×16cm and put it in a glass dish, soak it for 3 minutes, then take it out and let it dry naturally;

[0078] 3. Put the dried glass fiber paper into the tube furnace (OTL1200), and close the tube furnace to check the air tightness.

[0079] 4. Turn on the vacuum pump to pump the air pressure of the tube furnace to the limit vacuum state: 3×10 -6 Torr;

[0080] 5. Keep vacuum state 3×10 -6 After Torr for 15 minutes (the effect of vacuum for 15 minutes is to remove impurities, air, etc. inside the quartz tube ...

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Abstract

The invention discloses a molybdenum disulfide / gold nanoparticle mixed structure biosensor material and a preparation method thereof. The molybdenum disulfide / gold nanoparticle mixed structure biosensor material comprises a glass fiber paper substrate, two-dimensional molybdenum disulfide adhered to the glass fiber paper substrate and gold nanoparticles adhered to the two-dimensional molybdenum disulfide. Molybdenum disulfide growth temperature is accurately controlled. Grown molybdenum disulfide has low defect peak and high crystalline quality. Grown molybdenum disulfide size is only limited by CVD cavity, and large-area growth of molybdenum disulfide can be realized. The molybdenum disulfide / metal particle mixed structure with grown metal particles has extremely high chemisorption and physical strengthening mechanisms. By the etching method for growth of gold particles, etching time can be controlled to accurately control size of the gold particles. In addition, the gold particles can uniformly grow on the whole material, which is beneficial to detection of biomolecules. The prepared biosensor can simultaneously realize separation and detection of biomolecules. The method is simple and controllable, is low-cost, and has high application value.

Description

technical field [0001] The present invention relates to the preparation of a biosensor (hereinafter referred to as "separable biosensor") material that can separate mixed biomolecules, in particular to a biosensor material with molybdenum disulfide / gold nanoparticle mixed structure and its preparation method, belonging to The field of new material technology. Background technique [0002] Molecules are detected using surface-enhanced Raman scattering (SERS) technology. Raman spectroscopy, like infrared spectroscopy, belongs to molecular vibration spectroscopy, which can reflect the characteristic structure of molecules. However, the Raman scattering effect is a very weak process, and generally its light intensity is only about 10^-10 of the incident light intensity. Therefore, the Raman signals are very weak, and some kind of enhancement effect is almost always used to study the Raman spectroscopy of surface adsorbed species. Regarding surface-enhanced Raman scattering, t...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 杨诚王均东张萌徐媛媛潘萧萧欧佳瑜满宝元
Owner SHANDONG NORMAL UNIV
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