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Ferroferric oxide/chitosan/indocyanine green composite particles and preparation method and application thereof

A technology of ferric oxide and indocyanine green, which is applied in the direction of wave energy or particle radiation treatment materials, drug combinations, preparations for in vivo tests, etc., to achieve good synergistic effects of chemotherapy and photothermal therapy, low cost, and short The effect of the preparation cycle

Inactive Publication Date: 2017-03-22
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing cancer treatment methods mainly include chemotherapy and radiotherapy, and these methods have more or less disadvantages

Method used

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  • Ferroferric oxide/chitosan/indocyanine green composite particles and preparation method and application thereof
  • Ferroferric oxide/chitosan/indocyanine green composite particles and preparation method and application thereof
  • Ferroferric oxide/chitosan/indocyanine green composite particles and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Fe in this example 3 o 4 The preparation method of / chitosan / indocyanine green nano composite particle comprises the following steps:

[0046] (1) Fe 3 o 4 @CS Magnetic nanoparticles: Fe 3 o 4 The preparation method of @CS magnetic nanoparticles adopts a modified solvothermal reduction method, as follows: add 3.60g of FeCl to a three-necked flask 3 ·6H 2 O, and add 60mL of ethylene glycol solvent to completely dissolve it. Then, slowly add 20mL of ethylene glycol solution with 1.2g of chitosan (CS) into the above solution under stirring, and then slowly drop 20mL of ethylene glycol solution with 12g of sodium acetate Added to the above reaction solution. After the mixture was vigorously stirred for 60 minutes under an argon atmosphere, the temperature was slowly raised to 185° C., and kept under stirring for 48 hours. During the reaction, sodium acetate was Fe 3 o 4 The formation provides oxygen atoms, and ethylene glycol acts as a reducing agent for Fe 3 o ...

Embodiment 2

[0060] This embodiment is basically the same as Example 1, except that the amount of chitosan added in this embodiment is 1.0 g.

Embodiment 3

[0062] This embodiment is basically the same as Example 1, except that the amount of chitosan in this embodiment is 1.5 g.

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Abstract

The invention relates to ferroferric oxide / chitosan / indocyanine green composite particles and a preparation method and application thereof. The composite particles are indocyanine-green-supported Fe3O4@chitosan core-shell structured nanoparticles, wherein Fe3O4 nanoparticles serve as cores, chitosan serves as shells, and indocyanine green is supported on the outer surface of the chitosan. The preparation method includes preparing the Fe3O4@chitosan core-shell structured nanoparticles through a one-step heat reduction method; dispersing the prepared Fe3O4@chitosan core-shell structured nanoparticles into a water solution of the indocyanine green, disposing the mixture at a room temperature, stirring away from light, centrifuging, washing and taking lower-layer solids into deionized water so as to obtain the ferroferric oxide / chitosan / indocyanine green composite particles. Compared with the prior art, the ferroferric oxide / chitosan / indocyanine green composite particles have the advantage that the ferroferric oxide / chitosan / indocyanine green composite particles can be used as an infrared photo-thermal therapeutic agent, a drug carrier, a nuclear magnetic resonance imaging contrast agent or a fluorescence imaging contrast agent. The preparation method has the advantages of simple technological steps, good controllability, low economic cost and suitability for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of targeted drugs, and relates to ferric oxide / chitosan / indocyanine green composite particles and its preparation and application. Background technique [0002] In recent years, due to changes in people's lifestyles and environmental pollution, the growth rate of cancer cases has accelerated. Existing cancer treatment methods mainly include chemotherapy and radiotherapy, and these methods have more or less disadvantages. At the same time, the development of nanotechnology, especially the leapfrog development of nanocarriers in the application of biomedicine, has given birth to the development of a new field of "nanomedicine". Therefore, designing and controlling the structure and properties of nanoparticles and further exploring their applications in biomedicine are research hotspots in recent years. Nanocarriers have unique physical and chemical properties due to their size of 1-100 nm in structure. Thei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K49/06A61K49/18A61K41/00A61K47/36A61K47/02A61K31/704A61P35/00B82Y5/00
CPCA61K31/704A61K41/0052A61K47/02A61K47/36A61K49/0034A61K49/12A61K49/1818B82Y5/00
Inventor 王烨颖刘锡建高志方闫大伟马国昌黄智陆杰
Owner SHANGHAI UNIV OF ENG SCI
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