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Fusarium endophytic fungus with huperzine-A-producing function and application thereof

An endophytic fungus, huperzine A technology, applied in the field of pharmaceutical microorganisms, can solve the problems of difficulty in obtaining pure optically active compounds, lack of plant resources, high cost, etc., to meet the needs of drug use, protect plant resources, and reduce the cost of medicine The effect of fees

Active Publication Date: 2017-03-15
陕西仁达康健医药生物科技有限公司
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Problems solved by technology

[0006] The purpose of the present invention is to provide a Fusarium endophytic fungus with the function of producing huperzine A, which solves the bottleneck of plant resource shortage in obtaining huperzine A from plant extraction; and the chemical synthesis steps are cumbersome and expensive, and it is difficult to obtain pure optical active compound problem

Method used

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  • Fusarium endophytic fungus with huperzine-A-producing function and application thereof
  • Fusarium endophytic fungus with huperzine-A-producing function and application thereof
  • Fusarium endophytic fungus with huperzine-A-producing function and application thereof

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Embodiment Construction

[0024] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0025] The present invention is an endophytic fungus of the genus Fusarium with the function of producing huperzine A. The bacterial strain is obtained from the endophytic fungus of the wild Huperzia serrata (Huperzia serrata Huperzia family, Huperzia genus), and belongs to the Fusarium genus Fusarium verticillum (Fusarium verticillioides) NSH-5 strain has genetic stability after 20 generations in the laboratory, and its amino sequence is shown in SEQ ID NO:1.

[0026] The strain has been preserved in China Ordinary Microorganism Culture Collection Center, a preservation unit designated by the State Intellectual Property Office.

[0027] (1) the isolation method of the present invention highly expresses huperzine A bacterial strain is as follows:

[0028] After washing the fresh Hupercia serrata plants with tap water, first disinfect the sur...

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Abstract

The invention discloses a Fusarium endophytic fungus with huperzine-A-producing function. The strain is separated from a wild Huperzia serrata (Huperziaceae, Huperzia) endophytic fungus, belongs to a (Fusarium verticillioides) NSH-5 strain, and has hereditary stability after 20 generations of passage in the laboratory. The amino sequence is disclosed as SEQ ID NO:1. The fungus strain can be used as a biological strain for treating vascular dementia and senile dementia; the excellent huperzine-producing high-efficiency expression gene is transformed into the type strains to obtain more favorable characters by gene modification; and besides, induced mutation breeding can be performed to further optimize the strain.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical microorganisms, and specifically relates to an endophytic fungus of the genus Fusarium with the function of producing huperzine A, and also relates to the application of the fungal strain. Background technique [0002] Alzheimer's disease, also known as senile dementia (Alzheimer's disease, AD) is a neuron degenerative disease characterized by progressive dementia, mainly manifested as progressive cognitive dysfunction, personality and behavior changes, memory loss etc., resulting in the death of the patient within 7-10 years after the illness. According to the estimates of the International Alzheimer's Disease Association, there were about 36 million dementia patients in the world in 2010, and it is estimated that the number of AD patients will reach 115 million by 2050. Vascular dementia (Vascular dementia, VD) is an acquired intellectual impairment syndrome caused by brain dysfunction c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/14C12P17/12A61K36/06A61P25/28C12R1/77
CPCA61K36/06C12P17/12C12R2001/77C12N1/145
Inventor 韩文霞韩忠文李伟泽贾敏孙静韩贝诺贺洁周永强
Owner 陕西仁达康健医药生物科技有限公司
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