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Thermosensitive poly(proline-sarcosine) material and preparation method thereof

A technology of proline and sarcosine, which is applied in the field of temperature-sensitive poly(proline-sarcosine) materials and their preparation, can solve the problem of not having biocompatibility, biodegradability and temperature-sensitive properties at the same time , single and other problems, to achieve the effect of excellent temperature response characteristics, excellent biocompatibility and biodegradability

Inactive Publication Date: 2018-12-25
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a temperature-sensitive poly(proline-sarcosine) to solve the technical problem that the polymer materials prepared by modification cannot simultaneously have biocompatibility, biodegradability and temperature-sensitive properties in the prior art. Acid) material and preparation method thereof The polymer material of the present invention is a single polymer, rather than a mixture, a blend, or a graft of various polymers, and the polymer material has excellent biocompatibility, biocompatibility, and Degradability and temperature sensitivity properties

Method used

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  • Thermosensitive poly(proline-sarcosine) material and preparation method thereof
  • Thermosensitive poly(proline-sarcosine) material and preparation method thereof
  • Thermosensitive poly(proline-sarcosine) material and preparation method thereof

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Effect test

Embodiment 1

[0038] (1) Synthesis of anhydride in N-carboxy-sarcosine ring

[0039] Add 2.0 g of sarcosine and 40 mL of anhydrous THF into a 100 mL three-necked round-bottomed flask equipped with a reflux condenser, and add 3.0 g of triphosgene in the oil bath to 60°C. React for about 2 hours, stop the reaction when the reaction suspension turns from light yellow to clear. Then pass N into the reaction system 2 To remove triphosgene and by-product HCl gas that did not participate in the reaction. After 2h, it was subjected to rotary evaporation, the reaction solution was concentrated to 2-3 mL, and slowly dropped into 50 mL of anhydrous n-hexane. Let the system stand at room temperature for 48 hours. It can be observed that solid crystals appear at the bottom of the container. Pour off the supernatant, add anhydrous tetrahydrofuran to dissolve the solid crystals, sink into n-hexane again, and repeat 2-3 times to obtain a white powder. solid.

[0040] The reaction equation is as follows...

Embodiment 2

[0051] (1) Synthesis of anhydride in N-carboxy-sarcosine ring

[0052] Add 3.0 g of sarcosine and 50 mL of anhydrous THF into a 100 mL three-neck round bottom flask equipped with a reflux condenser, and add 4.50 g of triphosgene in the oil bath to 50°C. After about 2.5 hours of reaction, stop the reaction when the reaction suspension turns from light yellow to clear. Then pass dry N into the reaction system 2 To remove triphosgene and by-product HCl gas that did not participate in the reaction. After 3 hours, it was subjected to rotary evaporation, the reaction solution was concentrated to about 6 mL, and slowly dropped into 50 mL of anhydrous petroleum ether / n-hexane mixed solvent. The system was left standing at room temperature for 36 hours, and solid crystallization could be observed at the bottom of the container. The supernatant was removed by filtration, and anhydrous tetrahydrofuran was added to dissolve the solid, which was then sunk into n-hexane again. This opera...

Embodiment 3

[0064] (1) Synthesis of anhydride in N-carboxy-sarcosine ring

[0065] Add 2.0 g of sarcosine and 40 mL of anhydrous chloroform into a 100 mL three-necked round-bottom flask, and heat the oil bath to 50° C., then add 3.0 g of triphosgene. After 3.5 hours of reaction, the reaction system changed from a suspension to a clear state, and the reaction was stopped. Pass N into the reaction system 2 To remove triphosgene and by-product HCl gas that did not participate in the reaction. After 2.5 h, it was subjected to rotary evaporation, the reaction liquid was concentrated to about 4 mL, and slowly dropped into 40 mL of anhydrous n-hexane. The system was left standing at room temperature for 50 h, and solid crystallization could be observed at the bottom of the container. Pour out the supernatant, add anhydrous tetrahydrofuran to dissolve the solid crystals, and sink into n-hexane again. This operation is repeated 3-4 times to obtain N-carboxy-sarcosine cyclic anhydride. The reac...

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Abstract

The invention discloses a thermo-sensitive poly(proline-creatine) material, belongs to the field of thermo-sensitive polymers in smart materials and relates to a polymer material with the advantages of high biocompatibility, biodegradability and thermo-sensitivity. The thermo-sensitive poly(proline-creatine) material is composed of constitutional units shown in a formula (I), is a random copolymer and has a molecular weight of (0.8-1.6)*10<4>, wherein the structural formula is as shown in the specification, and a ratio of n to m is equal to 1:(0.09-0.76). The invention also discloses a method for preparing the thermo-sensitive poly(proline-creatine) material. The polymer material prepared by the invention has the thermo-sensitivity and excellent biocompatibility and biodegradability.

Description

technical field [0001] The invention belongs to the field of temperature-sensitive polymers in intelligent materials, and relates to a molecular design and preparation method of a polymer material with good biocompatibility, biodegradability and temperature-sensitive properties, in particular to a temperature-sensitive polymer material. Poly(proline-sarcosine) material and preparation method thereof, the polymer material itself is a single polymer, rather than a mixture, graft, or blend of two or more polymers in the modification method thing. Background technique [0002] Temperature-sensitive polymer materials are a class of intelligent materials that have reversible corresponding behaviors to external temperature changes. One of the most important physical parameters is the lowest critical solution temperature (LCST) or the highest critical solution temperature (UCST), that is, the polymer The temperature at which a significant phase change reversibly occurs in an aqueou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G69/10C08G69/08
CPCC08G69/08C08G69/10
Inventor 邓奎林杨震阿古达赵漫徐俊连赵慢岳颖
Owner HEBEI UNIVERSITY
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