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A kind of composite nanoparticle with Janus structure and preparation method and application thereof

A technology of composite nanoparticles and particles, applied in the field of materials

Active Publication Date: 2020-01-03
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity of the synthesis process, there are few studies on the synthesis of transition metal oxide-oxide anisotropic nanostructures. How to realize the simple synthesis of transition metal oxide-oxide anisotropic nanostructures is still a huge challenge. challenge

Method used

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  • A kind of composite nanoparticle with Janus structure and preparation method and application thereof
  • A kind of composite nanoparticle with Janus structure and preparation method and application thereof
  • A kind of composite nanoparticle with Janus structure and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0140] The present invention also provides a kind of preparation method of described composite nanoparticle, described method comprises the steps:

[0141] 1) providing a first mixed solution, a second mixed solution and an optional third mixed solution, wherein,

[0142] The first mixed solution contains a first solvent and a compound containing transition metal A dissolved in the first solvent;

[0143] The second mixed solution contains a second solvent and transition metal B oxide particles;

[0144] The third mixed solution contains a third solvent and transition metal C oxide particles;

[0145] 2) under stirring conditions, mixing the first mixed solution with the second mixed solution or the premixed solution of the treated second mixed solution and the third mixed solution to obtain the first solution;

[0146] 3) low-temperature heat treatment step 2) to obtain the first solution or use a vacuum pump to remove air in the first solution obtained in step 2) to obtain...

Embodiment 1

[0196] Example 1 Hydrophobic TiO 2 Preparation of nanoparticles

[0197] At room temperature, 1.7 mL of 5 mmol tetrabutyl titanate was dissolved in 16 mL of oleic acid / oleylamine / ethanol (the volume ratio of the three was 7:5:4) and stirred for 20 minutes; The air was removed; the solution was heated to 260°C, and kept under stirring for 2 hours; after the reaction, the precipitated product was collected and washed several times with absolute ethanol; finally, the synthesized TiO 2 The nanoparticles were dispersed in 15 ml of non-polar solvent (such as n-hexane, toluene, etc.).

[0198] result

[0199] The morphology and particle size of the obtained nanoparticles were analyzed.

[0200] Embodiment 1 gained TiO 2 The shape of the nanoparticles is spherical, and the particle diameter is about 3-6nm.

Embodiment 2

[0201] Example 2 Hydrophobic Gd 2 o 3 Preparation of nanoparticles

[0202] (1) Preparation of gadolinium oleate: under stirring at room temperature, 3 g of GdCl 3 Dissolve in 15 ml of deionized water, then add 7 g of sodium oleate to GdCl 3 Then add 5 milliliters of water, 25 milliliters of ethanol and 45 milliliters of n-hexane, heat the above mixed solution to 80°C and keep it warm for 4 hours; after complete reaction, use a separatory funnel to separate the organic matter in the upper layer, and wash the organic layer with warm water ; Finally, dry the washed organic layer at 40°C to obtain gadolinium oleate.

[0203] (2)Gd 2 o 3 Preparation of nanoparticles: Dissolve 2 g of gadolinium oleate in 18 ml of oleic acid with stirring at room temperature, then heat the mixed solution to 310 ° C, and 2 Incubate under protection for 30 minutes; after the reaction is completed, cool the product to room temperature, collect the precipitate, and wash it with acetone for 3 times...

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Abstract

The invention relates to a composite nanoparticle with a Janus structure and a preparation method and application thereof. Specifically, the particle has a structure shown as a formula I and a formula II, in the formulas, X represents an oxide particle of transition metal A, Y represents an oxide particle of transition metal B, Z represents an oxide particle of transition metal C, and the particle has the characteristic of producing a magnetic resonance imaging weighting signal. When the transition metal is Mn, a transition metal oxide is Mn3O4. The invention further discloses the preparation method and application of the particle. The particle is applied to the weighting MRI process, a clearer imaging effect and higher sensitivity than flat scanning can be obtained, and the treatment process can also be visually monitored in real time.

Description

technical field [0001] The invention relates to the field of materials, in particular to a composite nanoparticle with a Janus structure and a preparation method and application thereof. Background technique [0002] Materials science and technology, especially nanomaterials science and technology have made great progress. It is well known that the size and morphology of nanomaterials have an important impact on their physical and chemical properties. Therefore, controllable synthesis of nanomaterials with different morphologies to improve and enhance their performance has always been a hot spot for researchers. In recent years, inorganic nanocomposites have shown great application potential in life sciences due to their unique properties. Nanocomposites with different structures can be synthesized by different methods and techniques, such as matrix diffusion structure, core-shell structure and Janus structure nanocomposites. Among them, Janus-structured nanocomposites ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/18A61K49/06B82Y30/00B82Y40/00
Inventor 祖柏儿吴爱国曾乐勇马雪华
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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