Bionic extraction method of baicalin

Abstract

The invention provides a bionic extraction method of baicalin. The bionic extraction method comprises: (1) slicing a scutellaria baicalensis georgi herb or crushing a scutellaria baicalensis georgi herb into powder, preparing with H2SO4, HCl, H3PO4 and other reagent, heating the acid water to a temperature of more than 90-100 DEG C, pouring the scutellaria baicalensis georgi, maintaining the pH value of 1-3, carrying out thermal insulation for 2 h, carrying out stirring extraction, removing the waste liquid, and retaining the drug residue; (2) adding clear water to the retained drug residue, adding NaOH and adjusting the pH value to 6-8, carrying out thermal insulation for 1 h at a temperature of 60-90 DEG C, extracting to obtain an extraction liquid, adding HCl to the extraction liquid and adjusting the pH value to 1-2, and carrying out thermal insulation again to obtain a scutellaria baicalensis georgi crude product precipitate; and (3) adding water to the scutellaria baicalensis georgi crude product precipitate, stirring, adjust the pH value to 7 with concentrated NaOH, dissolving and filtering, removing the residue, retaining the filtrate, adding HCl to the filtrate to achieve the pH value of 2, carrying out thermal insulation for 30 min at a temperature of 50 DEG C to precipitate baicalin, filtering the precipitate, and washing with ethanol to obtain the baicalin fine product. According to the present invention, with the bionic extraction method, the extraction efficiency is high, the production cost can be significantly reduced, and the obtained baicalin has high purity and good quality.

Description

technical field [0001] The invention relates to the field of baicalin, in particular to a biomimetic extraction method of baicalin. Background technique [0002] Scutellaria baicalensis is the dry root of Scutellaria baicalensis plant of Labiatae. It is an important traditional Chinese medicine commonly used. It was first recorded in "Shen Nong's Herbal Classic" and has a long history of clinical application. Its main component, baicalin, is bitter in taste and cold in nature. It has the effects of purging excess fire, clearing heat and detoxifying, stopping bleeding and preventing miscarriage, lowering blood pressure, sedating, diuretic and choleretic, anti-inflammatory and anti-allergic. It is widely used clinically for pneumonia, hepatitis, chronic Bronchitis, high blood pressure, suppurative infection and threatened abortion and other diseases have a good curative effect. Modern pharmacological studies have shown that: baicalin can also destroy the enzyme activation sys...

AI Technical Summary

Problems solved by technology

[0003] At present, the extraction process of baicalin is complex, the removal of impurities is not thorough, the content of the finished product is not high, and the content of impurities in the finished product is high