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Method for preparing pharmaceutic silicified microcrystalline cellulose by silica hydrosol method

A technology of microcrystalline cellulose and silicon dioxide, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, inorganic non-effective ingredients, etc., can solve the problems of not obvious improvement of the fluidity of silicified microcrystalline cellulose, and achieve simplification The effect of the reaction process

Inactive Publication Date: 2017-02-08
安徽安生生物化工科技有限责任公司
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Han Peng and others pointed out in the article "Fluidity Evaluation of Silicified Microcrystalline Cellulose Powder" [Han Peng, Chen Fangcheng, Tu Jiasheng, "Journal of China Pharmaceutical University" 2013, 44(5): 416-420] that the combination of micropowder silica gel and microcrystalline cellulose The fluidity of silicified microcrystalline cellulose prepared by simple physical mixing of crystalline cellulose does not improve significantly

Method used

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preparation example Construction

[0009] In the preparation of silicified microcrystalline cellulose, simple physical mixing of microcrystalline cellulose acid and silicon dioxide is not easy to obtain products that fully meet the quality requirements of similar foreign products. The preparation of its physical method has already been done in China, but none of them can be compared with foreign products.

[0010] In order to solve the above defects, the inventor has developed a new preparation method of silicified microcrystalline cellulose auxiliary material through research. This method is to obtain a new type of medical silicified microcrystalline cellulose by chemically synthesizing silica gel and then processing it.

[0011] Therefore, a silicon dioxide hydrosol method is used to prepare medical silicified microcrystalline cellulose, including: the chemical method prepares silicon dioxide hydrosol and microcrystalline cellulose through mixing, filtering, washing, filtering, and drying processes to obtain s...

specific Embodiment

[0021] In order to enable those skilled in the art to better understand the technical solution of the invention, some non-limiting examples are further disclosed below to illustrate the present invention in detail.

[0022] The reagents used in the present invention can be purchased from the market or can be prepared according to the method of the present invention.

Embodiment 1

[0024] Weigh 1.90g of sodium metasilicate nonahydrate into the reactor, add hydrochloric acid to prepare silica gel, add 60mL of aqueous silica hydrosol, add 19.6g of medicinal microcrystalline cellulose prepared by cotton paddle, at room temperature ( 20°C~25°C) and stirred for 1 hour, the product was filtered to remove water, then dissolved in 40mL water, rinsed, filtered, and finally dried at 40~50°C to obtain the product.

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Abstract

The invention relates to a preparation method of a silicified microcrystalline cellulose pharmaceutic adjuvant and belongs to the technical field of pharmaceuticals industry. The method comprises the following steps: mixing microcrystalline cellulose with silica hydrosol, filtering, washing with water, filtering and drying to obtain silicified microcrystalline cellulose. According to the preparation method, silica gel is prepared in situ by a chemical method and then is synthesized with microcrystalline cellulose to obtain the silicified microcrystalline cellulose pharmaceutic adjuvant; a reaction end point can be effectively controlled, a reaction process is simplified, and the silicified microcrystalline cellulose according with the pharmaceutic quality is obtained.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a silica hydrosol method for preparing medicinal silicified microcrystalline cellulose. Background technique [0002] Silicified microcrystalline cellulose has the characteristics of original microcrystalline cellulose and micropowder silica gel: high fluidity, high dispersibility and good compressibility and all other advantages. It also has the special characteristics of both of them after copolymerization: good moisture absorption resistance, high expansion and compressibility. These properties make it have excellent processability of pharmaceutical excipients. In particular, it can be used to prepare new dosage forms such as traditional Chinese medicine dispersible tablets and orally disintegrating tablets. [0003] Silicified microcrystalline cellulose has been recorded in the Pharmacopoeia of the People's Republic of China and USP36-NF31 in the United States. Silicified ...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K47/04
CPCA61K47/02A61K47/38
Inventor 李凤和董志江边侠玲杨新宇王文博
Owner 安徽安生生物化工科技有限责任公司
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