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Method for extracting zeaxanthin and derivative of zeaxanthin from wolfberry

A technology of zeaxanthin and derivatives, which is applied in the direction of drug combination, bulk chemical production, cardiovascular system diseases, etc., can solve the problems of limiting zeaxanthin extraction, separation, deep processing and utilization, etc. Effects of fatigue, extraction process safety

Active Publication Date: 2017-01-25
WOLFBERRY ENG RES INST NINGXIA ACADEMY OF AGRI & FORESTRY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the traditional solvent extraction method limits the extraction and separation of zeaxanthin and its further deep processing and utilization due to factors such as solvent toxicity and residual; supercritical CO 2 Extraction technology Extraction of natural carotenoids is one of the main research and application fields of supercritical fluid extraction technology, and has increasingly become a hot spot in research and development at home and abroad
However, due to the influence of the high sugar content, water content and seed oil content of wolfberry, this technology is rarely used in the extraction of wolfberry zeaxanthin and its derivatives.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: a method for extracting zeaxanthin and its derivatives in Lycium barbarum, the method is to place the removed Lycium barbarum in 50°C water with 6-10 times the mass, let it stand for 1 hour, repeat 3 times, Drain and dry at room temperature or with hot air at 40°C. Reduce the total sugar content of wolfberry raw materials from 41%-45% to 25%-29%, and reduce the water content from 11%-12% to 10%-8%. Take 10kg of dried wolfberry, crush it to 100m mesh, and place Extraction in a supercritical extraction kettle. The extraction conditions are as follows: extraction temperature 35°C, extraction pressure 35Mpa, CO2 flow rate 300L / h, extraction time 3 hours, in which, 0.6h-3h extracts are collected together to obtain zeaxanthin and its derivatives. The extraction amount is 2-6kg / 100kg. After HPLC analysis and detection, the obtained extract is mainly zeaxanthin dipalmitate, zeaxanthin monopalmitate, zeaxanthin, cryptoxanthin and β-carotene. Among them, the conte...

Embodiment 2

[0017] Embodiment 2: a method for extracting zeaxanthin and its derivatives in Lycium barbarum, the method is to place the removed Lycium barbarum in 50°C water with 6-10 times the mass, let it stand for 1 hour, repeat 3 times, Drain and dry at room temperature or with hot air at 50°C. The total sugar content of wolfberry raw materials is reduced from 41%-45% to 25%-29%, and the water content is reduced from 11%-12% to 10%-8%. Take 10kg of dried wolfberry, crush it to 100m mesh, and place it in a supercritical extraction kettle for extraction. The extraction conditions are: extraction temperature 45°C, extraction pressure 45Mpa, CO 2 The flow rate is 370L / h, and the extraction time is 3 hours, among which, the combined and collected 0.6h-3h extracts are the obtained zeaxanthin and its derivatives. The extraction amount is 2-6kg / 100kg. After HPLC analysis and detection, the obtained extract is mainly zeaxanthin dipalmitate, zeaxanthin monopalmitate, zeaxanthin, cryptoxanthin ...

Embodiment 3

[0018] Embodiment 3: a method for extracting zeaxanthin and its derivatives in Lycium barbarum, the method is to place the removed Lycium barbarum in 50°C water with 6-10 times the mass, let it stand for 1 hour, repeat 3 times, Drain and dry at room temperature or with hot air at 45°C. The total sugar content of wolfberry raw materials is reduced from 41%-45% to 25%-29%, and the water content is reduced from 11%-12% to 10%-8%. Take 10kg of dried wolfberry, crush it to 100m mesh, and place it in a supercritical extraction kettle for extraction. The extraction conditions are: extraction temperature 40°C, extraction pressure 40Mpa, CO 2 The flow rate is 350L / h, and the extraction time is 3 hours, among which, the combined and collected 0.6h-3h extracts are the obtained zeaxanthin and its derivatives. The extraction amount is 2-6kg / 100kg. After HPLC analysis and detection, the obtained extract is mainly zeaxanthin dipalmitate, zeaxanthin monopalmitate, zeaxanthin, cryptoxanthin ...

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Abstract

The invention relates to a method for extracting active substances from a wolfberry, in particular to a method for extracting zeaxanthin and a derivative of the zeaxanthin from the wolfberry. The method comprises the steps of performing sugar reduction on the wolfberry, drying 10 kg wolfberry, grinding into 100 meshes, putting the wolfberry in a supercritical extraction kettle for extraction, merging and collecting an extract for 0.6-3 h to obtain the zeaxanthin and the derivative of the zeaxanthin. The method does not use an organic solvent in the whole process, and is safe and efficient, technical parameters are applicable to pilot-plant-scale production, and the purity reaches 80% or above.

Description

technical field [0001] The invention relates to a method for extracting effective substances in wolfberry, in particular to a method for extracting zeaxanthin and derivatives thereof in wolfberry. Background technique [0002] Zeaxanthin is an oxygen-containing carotenoid with the molecular formula C 40 h 58 o 2 , mainly exists in dark green vegetables, egg yolks, corn, citrus fruits, etc., and cannot be directly synthesized by the human body. Zeaxanthin is widely distributed in human serum, liver and other tissues, with the highest density in the macula of the retina. They are the most effective ingredients to prevent retinal damage caused by light exposure. The entry of zeaxanthin into the retina is mediated by specific binding proteins. At present, age-related macular degeneration and cataract are several common eye diseases that cause visual impairment or even blindness. There have been many studies on the relationship between zeaxanthin and cataract at home and abro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C403/24A61P27/02A61P9/00
CPCC07C403/24Y02P20/54
Inventor 闫亚美曹有龙米佳罗青禄璐李晓莺李越鲲冉林武张曦燕安巍
Owner WOLFBERRY ENG RES INST NINGXIA ACADEMY OF AGRI & FORESTRY SCI
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