Technology for producing Omega-3-ethyl gallate 90 from low-content ethyl ester fish oil

A technology of ethyl ester fish and ethyl acetate, which is applied in the pharmaceutical field, can solve the problems of large solvent consumption, influence product quality, long process, etc., and achieve the effects of reducing raw material consumption and production cost, shortening production cycle and ensuring product quality.

Inactive Publication Date: 2017-01-25
山东康曼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages of the original process flow: first, the process is too long, second, the solvent consumption is large, and third, the product quality is affected during rectification

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add 750kg of ethanol and 380kg of urea into a 3000L glass-lined reactor. Under the protection of nitrogen, stir and heat to ethanol 75°C. After the urea is dissolved, add 190kg of low-content ethyl ester fish oil. Continue to keep warm for 1.5 hours, then cool to 14°C. Centrifuge to remove urine package. Part of the ethanol was distilled from the filtrate under reduced pressure at 50°C, washed twice with 500 kg of water, and the lower part of the water layer was separated. Add 3.3kg of clay and 2.0kg of activated carbon to the oil layer, vacuum decolorize at 80°C, and filter out the mixture of clay and activated carbon. The filtrate enters the molecular distillation equipment, the primary temperature control is 110°C, the vacuum degree is 35Pa, the secondary temperature control is 150°C, the vacuum degree is 8Pa, and 77.3kg of colorless omega-3-acid ethyl ester 90 is obtained.

[0019] Measure the result with European Pharmacopoeia 8.0 method:

[0020] EPA-E=49.52% ...

Embodiment 2

[0025] Add 700kg of ethanol and 340kg of urea into a 3000L glass-lined reactor. Under the protection of nitrogen, stir and heat to ethanol 72°C. After the urea is dissolved, add 190kg of low-content ethyl ester fish oil. Continue to keep warm for 1.0 hour, then cool to 12°C. Centrifuge to remove urine package. After distilling part of the ethanol under reduced pressure at 46°C, the filtrate was washed twice with 450 kg of water, and the lower part of the water layer was separated. Add 4.5kg of clay and 3.2kg of activated carbon to the oil layer, vacuum decolorize at 82°C, and filter out the mixture of clay and activated carbon. The filtrate enters the molecular distillation equipment, the primary temperature control is 103°C, the vacuum degree is 42Pa, the secondary temperature control is 155°C, the vacuum degree is 6Pa, and 80.6kg of colorless omega-3-acid ethyl ester 90 is obtained.

[0026] Measure the result with European Pharmacopoeia 8.0 method:

[0027] EPA-E=48.92%...

Embodiment 3

[0032] Add 800kg of ethanol and 450kg of urea into a 3000L glass-lined reactor. Under the protection of nitrogen, stir and heat to ethanol 79°C. After the urea is dissolved, add 190kg of low-content ethyl ester fish oil. Continue to keep warm for 2.0 hours, then cool to 18°C. Centrifuge to remove urine package. After distilling part of the ethanol under reduced pressure at 53°C, the filtrate was washed twice with 550 kg of water, and the lower part of the water layer was separated. Add 2.8kg of clay and 2.1kg of activated carbon to the oil layer, vacuum decolorize at 81°C, and filter out the mixture of clay and activated carbon. The filtrate enters the molecular distillation equipment, the primary temperature control is 103°C, the vacuum degree is 47Pa, the secondary temperature control is 142°C, the vacuum degree is 8Pa, and 72.3kg of colorless omega-3-acid ethyl ester 90 is obtained.

[0033] Measure the result with European Pharmacopoeia 8.0 method:

[0034] EPA-E=50.12...

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PUM

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Abstract

The invention discloses a technology for producing Omega-3-ethyl gallate 90 from low-content ethyl ester fish oil. According to the technology, the low-content ethyl ester fish oil is directly subjected to urea inclusion reaction, subjected to decoloration, and then purified according to a molecular distillation method, so that the total content of the Omega-3-ethyl gallate 90 is not smaller than 93 percent, and the total content of EPA ethyl ester and DHA ethyl ester is not smaller than 85 percent. The technology does not need the complex process of performing decoloration and then rectification on a traditional product after the product is dissolved, thereby simplifying the process, is low in the amount of solvent, simple to operate, and suitable for large-scale production and operation, can obtain high-content Omega-3-ethyl gallate 90 products through a molecular distillation and purification mode, and effectively improves the product quality and the efficiency.

Description

technical field [0001] The invention relates to a process for producing omega-3-acid ethyl ester 90 from low-content ethyl ester fish oil, belonging to the technical field of pharmacy. Background technique [0002] Omega-3-acid ethyl ester 90 has been proved to be a class of drugs with strong pharmacological effects in medicine, containing eicosapentaenoic acid ethyl ester (EPA-E) and docosahexaenoic acid ethyl ester ( DHA-E), the two contain more unsaturated bonds, have a strong effect of regulating blood lipids, and also have the effects of dilating blood vessels and anti-thrombosis, can reduce plasma cholesterol, triglycerides, LDL, VLDL, increase HDL, Popular with patients, Eicosapentaenoic Acid Ethyl (EPA-E) and Docosahexaenoic Acid Ethyl (DHA-E) are two important indicators to measure the quality of Omega-3-Acid Ethyl 90 . [0003] In the existing technology, the technological process for preparing omega-3-acid ethyl ester 90 is: low-content ethyl ester fish oil→urin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C67/08C07C67/56C07C67/60C07C67/54C07C69/587
CPCC07C67/08C07C67/54C07C67/56C07C67/60C07C69/587
Inventor 胡自豪孙继朋马春季孙晋宝
Owner 山东康曼生物科技有限公司
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