Technology for producing Omega-3-ethyl gallate 90 from low-content ethyl ester fish oil
A technology of ethyl ester fish and ethyl acetate, which is applied in the pharmaceutical field, can solve the problems of large solvent consumption, influence product quality, long process, etc., and achieve the effects of reducing raw material consumption and production cost, shortening production cycle and ensuring product quality.
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Embodiment 1
[0018] Add 750kg of ethanol and 380kg of urea into a 3000L glass-lined reactor. Under the protection of nitrogen, stir and heat to ethanol 75°C. After the urea is dissolved, add 190kg of low-content ethyl ester fish oil. Continue to keep warm for 1.5 hours, then cool to 14°C. Centrifuge to remove urine package. Part of the ethanol was distilled from the filtrate under reduced pressure at 50°C, washed twice with 500 kg of water, and the lower part of the water layer was separated. Add 3.3kg of clay and 2.0kg of activated carbon to the oil layer, vacuum decolorize at 80°C, and filter out the mixture of clay and activated carbon. The filtrate enters the molecular distillation equipment, the primary temperature control is 110°C, the vacuum degree is 35Pa, the secondary temperature control is 150°C, the vacuum degree is 8Pa, and 77.3kg of colorless omega-3-acid ethyl ester 90 is obtained.
[0019] Measure the result with European Pharmacopoeia 8.0 method:
[0020] EPA-E=49.52% ...
Embodiment 2
[0025] Add 700kg of ethanol and 340kg of urea into a 3000L glass-lined reactor. Under the protection of nitrogen, stir and heat to ethanol 72°C. After the urea is dissolved, add 190kg of low-content ethyl ester fish oil. Continue to keep warm for 1.0 hour, then cool to 12°C. Centrifuge to remove urine package. After distilling part of the ethanol under reduced pressure at 46°C, the filtrate was washed twice with 450 kg of water, and the lower part of the water layer was separated. Add 4.5kg of clay and 3.2kg of activated carbon to the oil layer, vacuum decolorize at 82°C, and filter out the mixture of clay and activated carbon. The filtrate enters the molecular distillation equipment, the primary temperature control is 103°C, the vacuum degree is 42Pa, the secondary temperature control is 155°C, the vacuum degree is 6Pa, and 80.6kg of colorless omega-3-acid ethyl ester 90 is obtained.
[0026] Measure the result with European Pharmacopoeia 8.0 method:
[0027] EPA-E=48.92%...
Embodiment 3
[0032] Add 800kg of ethanol and 450kg of urea into a 3000L glass-lined reactor. Under the protection of nitrogen, stir and heat to ethanol 79°C. After the urea is dissolved, add 190kg of low-content ethyl ester fish oil. Continue to keep warm for 2.0 hours, then cool to 18°C. Centrifuge to remove urine package. After distilling part of the ethanol under reduced pressure at 53°C, the filtrate was washed twice with 550 kg of water, and the lower part of the water layer was separated. Add 2.8kg of clay and 2.1kg of activated carbon to the oil layer, vacuum decolorize at 81°C, and filter out the mixture of clay and activated carbon. The filtrate enters the molecular distillation equipment, the primary temperature control is 103°C, the vacuum degree is 47Pa, the secondary temperature control is 142°C, the vacuum degree is 8Pa, and 72.3kg of colorless omega-3-acid ethyl ester 90 is obtained.
[0033] Measure the result with European Pharmacopoeia 8.0 method:
[0034] EPA-E=50.12...
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