Application of cinnamaldehyde in the preparation of drugs for targeted treatment of bacterial infections

A technology for bacterial infection and targeted therapy, applied in the field of medicine, can solve problems such as untimely treatment, difficult clinical treatment of infectious diseases, and increased mortality.

Active Publication Date: 2018-08-21
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emergence of multi-drug resistant bacteria and outbreaks in hospital environments have made the treatment of clinical infectious diseases more difficult, with poor prognosis and increased mortality, especially for patients with immunodeficiency such as blood diseases, tumors, and organ transplants. Due to the limited choice of drugs for multi-drug resistant bacteria, such as CR-ABA, which is often only sensitive to polymyxin, and this drug is not available in China, many infections caused by this bacteria, especially for patients with bloodstream infections because there are almost no drugs available, Death due to untimely treatment; at the same time, multi-drug resistant bacteria are very easy to break out in the hospital environment, so this kind of bacteria has become a major problem in the clinical work of the hospital. In view of this, the development of safe, efficient and sensitive drugs has become a An urgent priority for the control and treatment of multidrug-resistant bacterial infections

Method used

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  • Application of cinnamaldehyde in the preparation of drugs for targeted treatment of bacterial infections
  • Application of cinnamaldehyde in the preparation of drugs for targeted treatment of bacterial infections
  • Application of cinnamaldehyde in the preparation of drugs for targeted treatment of bacterial infections

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 is cinnamaldehyde 1.25, Tween-80 0.05g.

[0036]1. Methods: 30 strains of non-repeated multidrug-resistant bacteria isolated from inpatients in the Second Hospital of Hebei Medical University were selected, including methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Acinetobacter baumannii (CR-ABA), carbapenem-resistant Klebsiella pneumoniae (CRE), carbapenem-resistant Pseudomonas aeruginosa (CR-PAE), vancomycin-resistant Enterococcus (VRE). At the same time, 28 strains of each of the above five non-multidrug-resistant Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterococcus faecium were selected to compare the effects of cinnamic aldehyde on the above bacteria. Effect.

[0037] Quality control strains: ATCC25922, ATCC25923, ATCC29212, ATCC27853.

[0038] 2. Results:

[0039] The results show that cinnamaldehyde has good sensitivity to multi-drug resistant bacteria, see Table 1

...

Embodiment 2

[0045] Embodiment 2 cinnamic aldehyde monomer clathrate of the present invention

[0046] Composition: Cinnamaldehyde 1.25g (50 parts by weight)

[0047] 2-hydroxypropyl-β-cyclodextrin 1.25g (50 parts by weight)

[0048] Preparation:

[0049] 1) Add 2-hydroxypropyl-β-cyclodextrin to 80°C deionized distilled water, stir to dissolve, then cool down to 20°C to prepare an aqueous solution for use; among them, 2-hydroxypropyl-β-cyclodextrin The weight mg / volume mL ratio of essence and deionized distilled water is 1:10;

[0050] 2) Under stirring, slowly add cinnamon aldehyde dissolved in ethyl acetate dropwise to the aqueous solution obtained in step 1). After the dropwise addition, raise the temperature to 70°C and continue stirring for 1 hour, then refrigerate for 24 hours to obtain a refrigerated solution , standby; wherein, the volume mL ratio of cinnamaldehyde to ethyl acetate is 1:6;

[0051] 3) Filter the refrigerated liquid obtained in step 2), wash the solid matter wit...

Embodiment 3

[0051] 3) Filter the refrigerated liquid obtained in step 2), wash the solid matter with a small amount of distilled water, dry it in vacuum at a low temperature of 5°C for 24 hours, grind it, sieve it through 80 mesh, wash it with ethyl acetate three times, and dry it in the air to obtain white Loose cinnamaldehyde monomer inclusion compound. Embodiment 3 cinnamic aldehyde monomer clathrate of the present invention

[0052] Composition: Cinnamaldehyde 1g (10 parts by weight)

[0053] 2-hydroxypropyl-β-cyclodextrin 2g (20 parts by weight)

[0054] Preparation method: with embodiment 2.

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Abstract

The invention relates to application of cinnamaldehyde in preparation of drugs for targeted therapy of bacterial infection, and belongs to the technical field of medicines. Bacteria are multi-drug-resistant bacteria such as methicillin-resistant staphylococcus aureus, carbapenem-resistant baumanii, carbapenem-resistant enterobacteriaceae, carbapenem-resistant pseudomonas aeruginosa or vancomycin-resistant enterococcus. By the research result of the invention, an efficient, low-toxicity and novel antibacterial medicine which is used for targeted therapy of multi-drug-resistant bacterial infection is provided for bacterial infection of departments such as a clinical pneumology department, a hematology department, an emergency treatment ICU, an oncology department and organ grafting, in-vivo pharmacodynamics, an action mechanism and a theoretical experiment basis are provided for research and development of traditional Chinese medicines for treating multi-drug-resistant bacterial infection, and conditions are created for transformation of scientific achievements.

Description

technical field [0001] The invention relates to the application of an active ingredient in the preparation of medicines, more specifically, relates to the application of cinnamaldehyde in the preparation of medicines for targeted treatment of bacterial infections, and belongs to the technical field of medicine. Background technique [0002] In recent years, due to the wide application of broad-spectrum antibiotics, multidrug-resistant bacterial infections in hospitals have increased year by year. In 2014, the monitoring data of China Hospital Antimicrobial Resistance Surveillance Network (CHINET) showed that MRSA is currently in 18 major hospitals in my country. Hospital incidence was 30-73%, 62-70% for carbapenem-resistant Acinetobacter baumannii (CR-ABA), and 24% for carbapenem-resistant Pseudomonas aeruginosa (CR-PAE) -26%, carbapenem-resistant Klebsiella pneumoniae (CR-KPN) was 10-13%, and vancomycin-resistant enterococcus (VRE) was 3-4%. The emergence of multi-drug resis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/11A61K47/69A61K47/26A61P31/04
CPCA61K31/11A61K47/26
Inventor 王刚生王晓路邓洁华李继红张朝军赵宜乐
Owner THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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