Application of cinnamon aldehyde in the preparation of drugs for targeted treatment of drug-resistant candida infection
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A technology of candida and cinnamaldehyde, applied in the field of medicine, can solve the problems of difficult clinical treatment and poor prognosis
Active Publication Date: 2018-08-21
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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Although the above-mentioned drugs have certain antibacterial effects, due to the increasing number of drug-resistant strains in recent years, especially resistant to azole drugs, such as fluconazole, itraconazole, voriconazole, ketoconazole, and flucytosine, Amphotericin B, etc., clinical treatment is still relatively difficult, and the prognosis is poor
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Embodiment 2
[0043] Embodiment 2 Cinnamaldehyde monomer clathrate of the present invention
[0044] Composition: Cinnamaldehyde 1.25g (50 parts by weight)
[0045] 2-hydroxypropyl-β-cyclodextrin 1.25g (50 parts by weight)
[0046] Preparation:
[0047] 1) Add 2-hydroxypropyl-β-cyclodextrin into deionized distilled water at 90°C, stir to dissolve, then cool down to 20°C to prepare an aqueous solution for later use; among them, 2-hydroxypropyl-β-cyclodextrin The weight mg / volume mL ratio of essence and deionized distilled water is 1:8;
[0048] 2) Under stirring, slowly add cinnamon aldehyde dissolved in ethyl acetate dropwise to the aqueous solution obtained in step 1). After the dropwise addition, raise the temperature to 70°C and continue stirring for 1 hour, then refrigerate for 24 hours to obtain a refrigerated solution , standby; wherein, the volume mL ratio of cinnamaldehyde to ethyl acetate is 1:6;
[0049] 3) Filter the refrigerated liquid obtained in step 2), wash the solid mat...
Embodiment 3
[0050] Embodiment 3 Cinnamaldehyde monomer clathrate of the present invention
[0051] Composition: Cinnamaldehyde 1g (10 parts by weight)
[0052] 2-hydroxypropyl-β-cyclodextrin 2g (20 parts by weight)
[0053] Preparation method: with embodiment 2.
Embodiment 4
[0054] Embodiment 4 Cinnamaldehyde monomer clathrate of the present invention
[0055] Composition: Cinnamaldehyde 6g (60 parts by weight)
[0056] 2-hydroxypropyl-β-cyclodextrin 8g (80 parts by weight)
[0057] Preparation method: with embodiment 2.
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Abstract
The invention relates to application of cinnamaldehyde in preparation of drugs for targeted therapy of drug-resistant monilial infection, and belongs to the technical field of medicines. Drug-resistant monilia is invasive and disseminative drug-resistant monilia such as monilia albicans, candida krusei, candida glabrata or candida parapsilosis. A cinnamaldehyde inclusion compound preparation is developed by methods of tissue mycology, tissue pathology, tissue biochemistry and tissue electron microscopy. An efficient, low-toxicity and novel antibacterial agent which is used for targeted therapy of drug-resistant monilial infection is provided for fungal infection of departments such as a clinical pneumology department, a hematology department, an emergency treatment ICU, an oncology department and organ grafting, in-vivo pharmacodynamics, an action mechanism and a theoretical experiment basis are provided for research and development of traditional Chinese medicines for treating invasive and disseminative drug-resistant monilial infection, and conditions are created for transformation of scientific achievements.
Description
technical field [0001] The invention relates to the application of an active ingredient in the preparation of medicines, more specifically, relates to the application of cinnamaldehyde in the preparation of medicines for targeted treatment of drug-resistant Candida infection, and belongs to the technical field of medicine. Background technique [0002] Invasive disseminated drug-resistant fungal infection refers to fungal invasion of human tissues and blood, where they grow and reproduce, causing tissue damage, organ dysfunction, pathological changes and pathophysiological processes of inflammatory response. In recent years, with the continuous promotion and development of organ transplantation and various catheter technologies, the irrational use of antibiotics, and the number of critically ill patients treated with ventilator-assisted ventilation and parenteral nutrition support, the number of critically ill patients has continued to increase, coupled with changes in the sp...
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