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Pharmaceutical composition capable of improving safety of compound obtuseleaf erycibe stem injection

A technology of compound Dinggongteng and its composition, which is applied in the field of medicine, can solve the problems of solution pH drop, polysorbate 80 is prone to rancidity, and accelerates the pH value of liquid medicine, etc., and achieves high dosage, improved safety, and good safety effects

Inactive Publication Date: 2017-01-25
CHENGDU XIANXIANXIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and polysorbate 80 (Tween 80) is prone to rancidity, which accelerates the drop of the pH value of the liquid medicine.

Method used

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  • Pharmaceutical composition capable of improving safety of compound obtuseleaf erycibe stem injection
  • Pharmaceutical composition capable of improving safety of compound obtuseleaf erycibe stem injection
  • Pharmaceutical composition capable of improving safety of compound obtuseleaf erycibe stem injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027] Preparation method: decoct Dinggongteng and rhubarb with water twice, each time for 2 hours, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrate to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure It is about 1.15 (80°C), and the liquid medicine is ready for use; add water to decoct Maodongqing twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), let it cool, add Ethanol so that the ethanol content is 65%, let stand overnight, filter, the filtrate is concentrated under reduced pressure to a relative density of 1.20 (80°C)...

Embodiment 2

[0029]

[0030] Preparation method: decoct Dinggongteng and rhubarb with water twice, each time for 2 hours, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrate to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure It is about 1.15 (80°C), and the liquid medicine is ready for use; add water to decoct Maodongqing twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), let it cool, add Ethanol so that the ethanol content is 65%, let stand overnight, filter, the filtrate is concentrated under reduced pressure to a relative density of 1.20 (80°C)...

Embodiment 3

[0032]

[0033]Preparation method: decoct Dinggongteng and rhubarb with water twice, each time for 2 hours, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrate to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure It is about 1.15 (80°C), and the liquid medicine is ready for use; add water to decoct Maodongqing twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), let it cool, add Ethanol so that the ethanol content is 65%, let stand overnight, filter, the filtrate is concentrated under reduced pressure to a relative density of 1.20 (80°C),...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for improving the safety of compound Dinggongteng injection, the pharmaceutical composition is mainly composed of Dinggongteng extract, rhubarb extract, hair holly extract and hexafluorobutyl methacrylate for injection pharmaceutical composition. The present invention adopts the co-solvent with better safety and more obvious solubilizing effect to replace the co-solvent polysorbate 80, which has potential safety hazards and affects product quality in the compound Dinggongteng injection, and the safety of hexafluorobutyl methacrylate is higher than that of polysorbate The ester 80 is high and the dosage is lower, which reduces the probability and risk of adverse drug reactions and improves the safety of clinical medication.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition for improving the safety of compound Dinggongteng injection. Background technique [0002] The standard of compound Dinggongteng injection is recorded in the drug standard issued by the Ministry of Health (Chinese medicine prescription preparation), and the raw materials are Dinggongteng, rhubarb and Maodongqing, which belong to traditional Chinese medicine injection. It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound Dinggongteng injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the cl...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/14A61K47/26A61K36/708A61P15/00A61P29/00
CPCA61K9/08A61K36/185A61K36/39A61K36/708A61K47/14A61K47/26
Inventor 付裕
Owner CHENGDU XIANXIANXIAN BIOTECH CO LTD
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