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Biocompatible hyper-dispersant preparation method

A hyperdispersant and biocompatible technology, which is applied in coatings and other directions, can solve the problems of metabolite toxicity, decreased dispersion stability, and poor biocompatibility, and achieve good biocompatibility, simple preparation steps, and high dispersion rate. high effect

Active Publication Date: 2017-01-18
广州市九合化工科贸有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention: Aiming at the disadvantages of the existing hyperdispersant that its biocompatibility is poor, its metabolites are toxic, and under acidic conditions, the protective layer formed by the dispersant becomes thinner, resulting in a decrease in its dispersion stability, providing A method of heating glycerin, sucrose, etc. in a mixed water bath, vacuuming and then heat preservation reaction, dripping epichlorohydrin water bath reaction, filtering to obtain filtrate, mixing with citric acid solution, filtering to obtain filtrate, concentrating to obtain modified base liquid, and Heating in an oil bath such as ε-caprolactone, filtering to obtain a filtrate, and standing still to obtain a biocompatible hyperdispersant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0016] First, weigh 45 parts of glycerin, 10 parts of sucrose, and 2 parts of plant ash in a three-necked flask, respectively, in terms of parts by weight. After passing nitrogen through the three-necked flask to remove the air, place the three-necked flask in a water bath at 65°C under a nitrogen atmosphere. Heating for 10 minutes, then evacuating the three-necked flask to 15Pa, and insulated for 1 hour; then, after the completion of the insulated reaction, use a high-pressure pump to drip epichlorohydrin accounting for 50% of the above-mentioned glycerin mass into the three-necked flask, and control the dropping time as 10min, after the dropwise addition is completed, control the vacuum degree to 0.05MPa, and heat the reaction in a water bath at 75°C for 1h; : 2, with the filtrate and mass concentration 10% citric acid solution, after stirring and mixing at room temperature for 1h, filter and collect the filtrate, rotate and evaporate to 1 / 5 of the original volume at 65°C, an...

example 2

[0019] First, weigh 48 parts of glycerin, 13 parts of sucrose, and 3 parts of plant ash in a three-necked flask, respectively, according to the number of parts by weight. After the three-necked flask is ventilated with nitrogen to remove the air, under a nitrogen atmosphere, the three-necked flask is placed in a water bath at 68 ° C. Heating for 13 minutes, then evacuating the three-necked flask to 18 Pa, and keeping the temperature for 2 hours; then, after the heat-retention reaction is completed, use a high-pressure pump to drip epichlorohydrin accounting for 50% of the above-mentioned glycerin mass into the three-necked flask, and control the dropping time as 13min, after the dropwise addition is completed, control the vacuum degree to 0.06MPa, and heat the reaction in a water bath at 78°C for 2h; : 2, with the filtrate and mass concentration 10% citric acid solution, after stirring and mixing at room temperature for 2h, filter and collect the filtrate, rotate and evaporate ...

example 3

[0022] First, weigh 50 parts of glycerin, 15 parts of sucrose, and 3 parts of plant ash in a three-necked flask, respectively, in parts by weight. After passing nitrogen to the three-necked flask to remove the air, place the three-necked flask in a water bath at 70°C under a nitrogen atmosphere. Heating for 15 minutes, then evacuating the three-necked flask to 20Pa, and insulated for 2 hours; then, after the heat-insulated reaction was completed, drip the epichlorohydrin accounting for 50% of the above-mentioned glycerin mass into the three-necked flask with a high-pressure pump, and control the dropping time as 15min, after the dropwise addition is completed, control the vacuum degree to 0.06MPa, and heat the reaction in a water bath at 80°C for 2h; : 2, with the filtrate and mass concentration 10% citric acid solution, after stirring and mixing at room temperature for 2h, filter and collect the filtrate, rotate and evaporate to 1 / 5 of the original volume at 70°C, and prepare ...

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Abstract

The invention discloses a biocompatible hyper-dispersant preparation method, and belongs to the technical field of hyper-dispersant preparation. The preparation method comprises: carrying out mixed water bath heating on glycerol, sucrose and the like, vacuumizing, carrying out a thermal insulation reaction, adding epichlorohydrin in a dropwise manner, carrying out a water bath reaction, filtering to obtain a filtrate, mixing with a citric acid solution, filtering to obtain a filtrate, concentrating to obtain a modified base liquid, carrying out oil bath heating on the modified base liquid, epsilon-caprolactone and the like, filtering to obtain a filtrate, and standing to obtain the biocompatible hyper-dispersant. According to the present invention, the preparation steps are simple, the obtained product has advantages of good biocompatibility, high dispersion stability, safety, environmental protection and no toxicity, and the protection layer does not generate the thinning phenomenon under the acidic condition.

Description

technical field [0001] The invention relates to a preparation method of a biocompatible hyperdispersant, belonging to the technical field of hyperdispersant preparation. Background technique [0002] Hyperdispersant, also known as super dispersant, is a special surfactant whose molecular structure contains two opposite groups in terms of solubility and polarity, one of which is a shorter polar group called a hydrophilic group. The characteristics of its molecular structure make it easy to orientate on the surface of the material or the two-phase interface, reduce the interfacial tension, and have a good dispersion effect on the water-based dispersion system. The molecular structure of traditional dispersants has certain limitations: the hydrophilic groups are not firmly bonded to the surface of particles with low polarity or non-polarity, and are easy to desorb, resulting in re-flocculation of ions after dispersion; the lipophilic groups do not have enough The length of the...

Claims

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Application Information

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IPC IPC(8): C08G63/664C08G65/28C08G63/85C09D7/12
CPCC08G63/664C08G63/823C08G65/2609
Inventor 周荣邹宇帆蒋玉芳
Owner 广州市九合化工科贸有限公司
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