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Inorganic nano-coating capable of regulating and controlling cell response and preparation method of inorganic nano-coating

An inorganic nano-coating and coating technology, applied in the field of medical devices, can solve problems such as damage and uncontrollability, and achieve the effects of changing side effects, satisfying mechanical matching, and easily controlling the proportion of coating components.

Inactive Publication Date: 2017-01-11
成都迈德克科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Inorganic thin films have good tissue compatibility, can promote the growth of endothelial cells, and accelerate the process of endothelialization, but at the same time, due to the damage of vascular tissue during stent implantation, such thin films cannot control the smooth muscle cells that cause intimal hyperplasia

Method used

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  • Inorganic nano-coating capable of regulating and controlling cell response and preparation method of inorganic nano-coating
  • Inorganic nano-coating capable of regulating and controlling cell response and preparation method of inorganic nano-coating
  • Inorganic nano-coating capable of regulating and controlling cell response and preparation method of inorganic nano-coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of copper-titanium composite thin films.

[0036] Copper-titanium composite films were deposited on the surface of L605 alloy by magnetron sputtering.

[0037] The cathode target materials are high-purity titanium target and high-purity copper target respectively, and the copper-titanium atomic ratio is realized by adjusting the target current, and the copper-titanium combination form can be realized by the deposition process such as deposition temperature, bias voltage, and time.

[0038] L605 alloy was cleaned ultrasonically with acetone. First use cleaning: put a little acetone in the beaker, the liquid level can exceed the sample by a little, and then use ultrasonic cleaning for 5 minutes. Then wash with absolute ethanol. Pour a little absolute ethanol into the beaker until the liquid level exceeds the sample by a little, then clean it with ultrasonic waves for 5 minutes. Finally wash with distilled water. Pour distilled water into the beaker, the li...

Embodiment 2

[0044] Preparation of copper-iron composite thin films.

[0045] Sample pretreatment and sputter cleaning are the same as in Example 1.

[0046] The cathode used in the experiment of the present invention is pure iron, and the arc is ignited under the pulse trigger voltage to generate iron plasma. A magnetic filter elbow is used to filter macroscopic particles and neutral particles. Under the action of sputtering bias, titanium ions and iron ions move to the surface of the substrate material, thereby forming a copper-iron degradable film on the surface of the material.

[0047] Establish a vacuum system, the base vacuum of the vacuum chamber is 1.0×10 -3 At Pa, start the sample rotation at a rotation rate of 30-40rp / m, turn on the sample stage heating system, and ensure that the substrate temperature is 200°C. Introduce argon gas, the gas flow rate is 60-100 sccm, and the vacuum chamber pressure is guaranteed to be 0.5-0.8 Pa. The sputtering power was set to 500W, the pulse...

Embodiment 3

[0051] Preparation of copper-zinc composite thin films.

[0052] Sample pretreatment and sputter cleaning are the same as in Example 1.

[0053] The cathode used in the experiment of the present invention is pure zinc, and the arc is ignited under the pulse trigger voltage to generate iron zinc ions. Under the action of sputtering bias, zinc ions and copper ions move to the surface of the base material, thereby forming a copper-zinc degradable film on the surface of the material.

[0054] Establish a vacuum system, the base vacuum of the vacuum chamber is 1.0×10 -3 At Pa, start the sample rotation at a rotation rate of 30-40rp / m, turn on the sample stage heating system, and ensure that the substrate temperature is 200°C. Introduce argon gas, the gas flow rate is 60-100 sccm, and the vacuum chamber pressure is guaranteed to be 0.5-0.8 Pa. The sputtering power was set to 500W, the pulse duty cycle was 20%, and the negative bias voltage of 200V was applied to the substrate. T...

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Abstract

The invention discloses inorganic nano-coating capable of regulating and controlling cell response and a preparation method of the inorganic nano-coating. The invention mainly aims to prepare a degradable metal composite film on the surface of a metal vascular stent; in particular, the film can regulate and control different response behaviors of smooth muscle cells and endothelial cells. The film adopts copper as a basic component and realizes high blood compatibility, cell regulation and control mechanism, degradation behaviors and physical properties by regulating and controlling the proportion of other components and a composite structure of the copper and other components. The coating is a metal nano-film, has high ductility and a good binding force, and is suitable for the mechanical requirements of machines in the using process. The invention also relates to a method for regulating and controlling different cell response behaviors by ions generated in the degradation process of the film.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to an inorganic nano-coating capable of regulating cell response behavior and a preparation method thereof. Background technique [0002] Improving the biocompatibility of cardiovascular biomaterials through surface modification has been recognized by domestic and foreign scholars and widely used clinically. Contacting the surface of the material with blood not only requires the material to have good blood compatibility and not produce thrombosis, but also expects the surface of the material to be endothelialized quickly to complete the blood supply remodeling of the vascular tissue. The current cardiovascular implanted devices include cardiovascular stents, artificial heart valves, vena cava filters, embolic devices, etc. Most of these medical devices are designed and processed with biomedical metal materials, which remain in blood vessels for a long time as vascular tiss...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/14A61L31/16C23C14/34C23C14/35C23C14/16
CPCA61L31/088A61L31/14A61L31/16A61L2300/102C23C14/165C23C14/345C23C14/3464C23C14/352
Inventor 刘恒全李峻峰张佩聪方守均苏方红
Owner 成都迈德克科技有限公司
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