A method for the determination of six aromatic amine compounds in mainstream cigarette smoke using online spe/lc-ms/ms
A technology of cigarette mainstream smoke and aromatic amines, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of cumbersome and time-consuming processing, human errors, etc., and achieve the effects of reducing sample analysis interference, high precision, and reducing pollution
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Embodiment 1
[0032] 1. Sample Preparation
[0033] Smoke the balanced and screened cigarettes according to the standard conditions stipulated in ISO 3308:2000, and use 4 Cambridge filters (φ44mm) to capture the particulate matter in the mainstream smoke of 20 cigarettes (each Cambridge filter captures 5 Particle phase in the mainstream smoke of cigarettes); the absorption bottle pre-filled with 25mL 2% formic acid solution was connected to the back of the trap through a hose to collect the gas phase.
[0034] Remove the absorption bottle for collecting the gas phase, add 0.25mL mixed internal standard (d 9 -o-toluidine, d 3 -o-anisidine, d 6 -2,6-Dimethylaniline, d 7 -1-aminonaphthalene and d 9 -4-aminobiphenyl), mix well, and directly enter the Online SPE / LC-MS / MS analysis.
[0035] Fold the Cambridge filter that has captured the particulate matter in the mainstream smoke of 20 cigarettes into a 250mL ground-mouth conical flask, add 1.0mL mixed internal standard and 100mL 2% formic a...
Embodiment 2
[0070] The Kentucky reference cigarette 3R4F was smoked according to the standard conditions stipulated in ISO 3308:2000. The particulate matter of 5 cigarettes was collected by each Cambridge filter, and the gas phase was collected in an absorption bottle containing 25mL of 2% formic acid solution.
[0071] Then according to the steps and conditions described in Example 1, sample processing and analysis were carried out. 6 parallel experiments were carried out and the determination was divided into 5 days. The relative standard deviations of the determination of each compound were respectively between 2.50-5.52% and 2.24-6.69, indicating that the method has good reproducibility and stability.
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