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Alginate composite antibiotic dressing and the preparation method

A compound antibacterial and alginate technology, which is applied in the field of medical biopolymer materials, can solve the problems of mechanical strength and anti-adhesion effect that have not been found yet, achieve good liquid absorption and moisture retention, shorten wound healing time, and promote the healing of works

Active Publication Date: 2017-01-04
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been reports on the application of silk fibroin and alginate composite materials in dressings. However, the composite materials formed are mostly new functions of adding materials, and it has not been found that the composite materials formed by the two can improve its anti-adhesion effect and enhance the anti-adhesion effect. report on mechanical strength

Method used

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  • Alginate composite antibiotic dressing and the preparation method
  • Alginate composite antibiotic dressing and the preparation method
  • Alginate composite antibiotic dressing and the preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0034] (1) Preparation of alginate fibers: ① Soak alginate at 30°C for 2.5 hours to pre-dissolve, then stir for 4 hours at a temperature of 60°C and a speed of 200r / min or at a temperature of 30°C and a speed of Stir at 200r / min for 4 hours, and finally filter with a filter cloth under a pressure of 0.1MPa to obtain the alginate spinning dope; Spinning, the spinning speed is 5m / min, and then coagulated in a coagulation bath containing 5% calcium ion aqueous solution or alcohol solution by mass fraction, stretched after coagulation, washed with water, separated into filaments, coiled, at a temperature of 100°C Alginate fibers are obtained after drying under hot air;

[0035](2) Preparation of silk fibroin film: ① Preparation of silk fibroin solution: Using salt-dissolving enzymolysis process, natural silkworm shells or silk were soaked in an organic solvent formed by mixing methyl ether and methanol at a volume ratio of 1:1 to Remove the waxy matter, carbohydrates and ash impu...

Embodiment 2

[0040] (1) Preparation of alginate fibers: ① Soak alginate at 40°C for 2 hours to pre-dissolve, then stir for 3 hours at a temperature of 40°C and a speed of 400r / min or at a temperature of 45°C and a speed of 300r / min Stir for 6 hours under the condition of 0.3 MPa, and finally filter with filter cloth under the pressure of 0.3MPa to obtain the alginate spinning stock solution; Silk, the spinning speed is 100m / min, and then coagulated in a coagulation bath containing 8% calcium ion aqueous solution or alcohol solution by mass fraction, stretched after coagulation, washed with water, divided into filaments, wound, at a temperature of 80 ° C Alginate fibers are obtained after drying under hot air;

[0041] (2) Preparation of silk fibroin film: ① Preparation of silk fibroin solution: using salt-dissolving enzymolysis process, soak natural silkworm shells or silk in an organic solvent formed by mixing methyl ether and ethanol at a volume ratio of 1:1 to Remove the waxy matter, c...

Embodiment 3

[0046] (1) Preparation of alginate fibers: ① Soak alginate at 35°C for 3 hours to pre-dissolve, then stir for 3.5 hours at a temperature of 50°C and a speed of 300r / min or at a temperature of 60°C and a speed of Stir at 400r / min for 7 hours, and finally filter with a filter cloth under a pressure of 0.2MPa to obtain the alginate spinning dope; Spinning, the spinning speed is 60m / min, and then coagulated in a coagulation bath containing 10% calcium ion aqueous solution or alcohol solution by mass fraction, stretched after coagulation, washed with water, separated into filaments, coiled, at a temperature of 70°C Alginate fibers are obtained after drying under hot air;

[0047] (2) Preparation of silk fibroin film: ① Preparation of silk fibroin solution: using salt-dissolving enzymolysis process, soak natural silkworm shells or silk in an organic solvent formed by mixing ether and methanol at a volume ratio of 1:1 to remove The waxy matter, carbohydrates and ash impurities in it...

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Abstract

The invention is within the field of medical biological macromolecules and in particular relates to an alginate composite antibiotic dressing and the preparation method. The present invention uses fibroin composite membrane as antiseptic, humectant and antiadhesive. Loading it on the alginate fiber, the finally obtained alginate composite antibiotic dressing clinically functions as protecting the wound surface, inhibiting the bacteria, stopping the bleeding, preventing from conglutination and speeding up the mending of the wounds. The preparation method of the antibiotic dressing is simple. The easy process makes it possible for large-scaled production. The so-formed alginate composite antibiotic dressing improves the force performance of alginate under the hygrometric state, overcomes the conglutination of alginate on bleeding wounds, at the same time it qualifies alginate with certain antimicrobal property. This is suitable for nursing typical wound surface, speeding up the mending process, and alleviates the pain for wound patients.

Description

technical field [0001] The invention belongs to the field of medical biopolymer materials, and in particular relates to an alginate composite antibacterial dressing and a preparation method thereof. Among them, the silk fibroin composite film is used as antibacterial agent, moisturizing agent and anti-adhesion agent, and it is loaded on the alginate fiber, and the alginate composite antibacterial dressing prepared by the final processing can protect the wound surface, Antibacterial, hemostatic, prevent adhesion and promote wound healing. Background technique [0002] Skin wounds are skin defects caused by mechanical, electrical, thermal, chemical and other factors or due to physiological abnormalities. Due to the ubiquity of human skin wounds, people have summed up many ways to care for wounds for thousands of years. Since 1962, animal physiologist Winten has found through research that in a humid environment, it is more conducive to the rapid healing of wounds. Since the...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/20A61L15/26A61L15/46A61L15/42D06M15/15D06M13/148D01F9/04D01D5/06D04H1/4258C07K14/435C07K1/14C08J5/18
CPCA61L15/20A61L15/26A61L15/28A61L15/32A61L15/425A61L15/46A61L2300/208A61L2300/232A61L2300/404A61L2300/412C07K14/43586C08J5/18C08J2389/00D01D5/06D01F9/04D04H1/4258D06M13/148D06M15/15C08L5/04C08L5/08C08L83/04
Inventor 卢亢陈锦涛熊亮
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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