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High-strength hydrogel with hydrogen bond strengthened ion driven shape memory, as well as preparation method and application of hydrogel

A high-strength, hydrogel technology that can be used in animal cells, vertebrate cells, embryonic cells, etc., to solve problems such as cytotoxicity and limited applications

Inactive Publication Date: 2016-12-07
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the types or concentrations of ions used in these hydrogels are toxic to cells, which limits their application in the field of cell medicine.

Method used

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  • High-strength hydrogel with hydrogen bond strengthened ion driven shape memory, as well as preparation method and application of hydrogel
  • High-strength hydrogel with hydrogen bond strengthened ion driven shape memory, as well as preparation method and application of hydrogel
  • High-strength hydrogel with hydrogen bond strengthened ion driven shape memory, as well as preparation method and application of hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The monomer 2-vinyl-4,6-diamino-1,3,5-triazine (91 mg, Tokyo Kasei Kogyo), acrylic acid (9 mg, about 9 μl, sigma), and the cross-linking agent polyethylene glycol di Acrylate (50mg, number average molecular weight 4000, sigma) was added in the 1.5ml centrifuge tube, after dissolving monomer and cross-linking agent with the dimethyl sulfoxide (DMSO) of 800 μ l, add photoinitiator Irgacure2959 (6mg, 1- [4-(2-Hydroxyethoxy)-phenylene]-2-hydroxy-2',2'-dimethylethanone, sigma). The solvent containing monomer, cross-linking agent and initiator was injected into the airtight mold, and the mold was irradiated in an ultraviolet curing box (XL-1000UV, Spectronics Corporation) for 40min to fully initiate free radical polymerization. Then the mold was opened to take out the gel, rinsed several times with phosphate buffer solution, and soaked for 3 days, and the above-mentioned phosphate buffer solution was replaced every 12 hours to obtain the high-strength shape memory hydrogel pr...

Embodiment 2

[0026] The monomer 2-vinyl-4,6-diamino-1,3,5-triazine (91 mg, Tokyo Kasei Kogyo), acrylic acid (9 mg, about 9 μl, sigma), and the cross-linking agent polyethylene glycol di Acrylate (100 mg, number average molecular weight 4000, sigma) was added to a 1.5 ml centrifuge tube, and after dissolving the monomer and cross-linking agent with 800 μl of dimethylformamide, 4 mg of azobisisobutyronitrile (ABIN) was added. Inject the solvent containing monomer, cross-linking agent and initiator into the closed mold, heat the reaction system above the initiation temperature of the initiator used and keep the initiation temperature for 1 hour to fully initiate free radical polymerization. Then the mold was opened to take out the gel, rinsed several times with phosphate buffer solution, and soaked for 3 days, and the above phosphate buffer solution was replaced every 12 hours to obtain the high-strength shape memory hydrogel prepared in Example 2, denoted as PVDT- PAA-1.

Embodiment 3

[0028] The monomer 2-vinyl-4,6-diamino-1,3,5-triazine (91 mg, Tokyo Kasei Kogyo), acrylic acid (9 mg, about 9 μl, sigma), and the cross-linking agent polyethylene glycol di Acrylate (34 mg, number average molecular weight 4000, sigma) was added into a 1.5 ml centrifuge tube, and after dissolving the monomer and crosslinking agent with 800 μl of dimethylacetamide, 7 mg of azobisisobutyronitrile was added. Inject the solvent containing monomer, cross-linking agent and initiator into the closed mold, heat the reaction system above the initiation temperature of the initiator used and keep the initiation temperature for 5 hours to fully initiate free radical polymerization. Then the mold was opened to take out the gel, rinsed repeatedly with phosphate buffer solution several times, and soaked for 3 days, and the above-mentioned phosphate buffer solution was replaced every 12 hours to obtain the high-strength shape memory hydrogel prepared in Example 3, denoted as PVDT- PAA-2.

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Abstract

The invention discloses high-strength hydrogel with hydrogen bond strengthened ion driven shape memory, as well as a preparation method and an application of the hydrogel. According to the hydrogel, 2-vinyl-4,6-diamino-1,3,5-triazine and acrylic acid are used as monomers, polyethylene glycol diacrylate is used as a cross-linking agent, under the effect of an initiating agent, copolymerization is performed so that the hydrogel is prepared, wherein the mass ratio of the 2-vinyl-4,6-diamino-1,3,5-triazine to the acrylic acid is (1-10) to 1, the mass ratio of the monomers to the cross-linking agent is 2 to 1, and the solid content of gel is 15wt%. The hydrogel disclosed by the invention has very high tensile strength and high compression resistance, and has shape memory under the stimulus of ions and the function of without damaging removed cells. The preparation method is simple, and products are easy to store for a long term storage and transport for a long distance.

Description

technical field [0001] The present invention relates to a kind of hydrogel and preparation method, more specifically, relate to a kind of 2-vinyl-4,6-diamino-1,3,5-triazine, acrylic acid copolymer (PVDT-co-PAA ) hydrogel and preparation method thereof, which have high strength, shape memory and non-destructive decellularization function. Background technique [0002] Hydrogel is a polymer material with cross-linked structure, which is hydrophilic but water-insoluble and can absorb a large amount of water (usually the water content is greater than 50% of the total mass) with water as the dispersion medium. As a kind of intelligent polymer, shape memory polymer can memorize its shape under the action of external stimuli and restore it in a specific environment. Shape memory polymers have been widely used as excellent biomedical materials because of their unique properties. Shape memory hydrogel, as a kind of shape memory polymer, has also attracted the attention of many rese...

Claims

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Application Information

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IPC IPC(8): C08F283/06C08F220/06C08F226/06C12N5/073
Inventor 刘文广任宗清
Owner TIANJIN UNIV
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