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3D printing method of sodium alginate/polyvinyl chloride all-physically-crosslinked double-network hydrogel scaffold

A 3D printing and polyvinyl alcohol technology, applied in medical science, prosthesis, additive processing, etc., can solve the problems that the mechanical properties cannot meet the needs of biological tissue materials, and do not solve the problem of good compatibility, so as to achieve excellent mechanical properties, Long service life and high water absorption

Active Publication Date: 2016-12-07
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The Chinese Patent Publication No. CN 103205107A discloses a tough and highly cohesive 3D printing molding material and its preparation method. A tough three-dimensional scaffold with better bonding strength and higher firmness has been produced, but this invention does not solve the problem of good compatibility with bio
Although the invention has high porosity and uniform pore size, its mechanical properties cannot meet the needs of biological tissue materials

Method used

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  • 3D printing method of sodium alginate/polyvinyl chloride all-physically-crosslinked double-network hydrogel scaffold
  • 3D printing method of sodium alginate/polyvinyl chloride all-physically-crosslinked double-network hydrogel scaffold
  • 3D printing method of sodium alginate/polyvinyl chloride all-physically-crosslinked double-network hydrogel scaffold

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Step 1: preparation of double network hydrogel scaffold material, including the following sub-steps:

[0043] Sub-step 1.1: Preparation of sol: Take 2g of sodium alginate (SA) and add it to 38g of deionized water to stir and disperse, place it in a constant temperature water at 65°C and reflux for 1 to 2 hours until the sodium alginate (SA) is completely dissolved to obtain seaweed Sodium acid solution;

[0044] Sub-step 1.2: Take 13.332g of polyvinyl alcohol (PVA) resin and add 40g of deionized water to stir and disperse, place in 95°C constant temperature water area to condense and reflux for 2 to 3 hours until the PVA is completely dissolved to obtain a PVA solution;

[0045] Sub-step 1.3: The SA solution in sub-step (1.1) and the PVA solution in sub-step (1.2) are fully mixed and stirred evenly to obtain a SA / PVA mixed solution.

[0046] Sub-step 1.4: Degas the mixed solution obtained in sub-step (1.3) in a vacuum oven at 95°C for 0.5h. After degassing is complete,...

Embodiment 2

[0054] Step 1: preparation of double network hydrogel scaffold material, including the following sub-steps:

[0055] Sub-step 1.1: Preparation of sol: Take 2g of sodium alginate (SA) and add it to 38g of deionized water to stir and disperse, place it in a constant temperature water at 65°C and reflux for 1 to 2 hours until the sodium alginate (SA) is completely dissolved to obtain seaweed Sodium acid solution;

[0056] Sub-step 1.2: Take 22.22g of polyvinyl alcohol (PVA) resin and add 66.667g of deionized water to stir and disperse, place in 95°C constant temperature water and reflux for 2 to 3 hours until the PVA is completely dissolved to obtain a PVA solution;

[0057] Sub-step 1.3: the SA solution in sub-step (1.1) is mixed with the PVA solution in sub-step (1.2) and stirred evenly to obtain a SA / PVA mixed solution.

[0058] Sub-step 1.4: Degas the mixed solution obtained in sub-step (1.3) in a vacuum oven at 95°C for 0.5h. After degassing is complete, slowly add 93.332g ...

Embodiment 3

[0065] Step 1: preparation of double network hydrogel scaffold material, including the following sub-steps:

[0066] Sub-step 1.1: Preparation of sol: Take 2g of sodium alginate (SA) and add it to 38g of deionized water to stir and disperse, place it in a constant temperature water at 65°C and reflux for 1 to 2 hours until the sodium alginate (SA) is completely dissolved to obtain seaweed Sodium acid solution;

[0067] Sub-step 1.2: Take 26.667g of polyvinyl alcohol (PVA) resin and add it to 80g of deionized water to stir and disperse, place it in a constant temperature water area at 95°C to condense and reflux for 2 to 3 hours until the PVA is completely dissolved to obtain a PVA solution;

[0068] Sub-step 1.3: The SA solution in sub-step (1.1) is fully mixed with the PVA solution in sub-step (1.2), and stirred evenly to obtain a homogeneous mixed solution.

[0069] Sub-step 1.4: Degas the mixed solution obtained in sub-step (1.3) in a vacuum oven at 95°C for 0.5h. After th...

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Abstract

The invention discloses a 3D printing method of a sodium alginate / polyvinyl chloride all-physically-crosslinked double-network hydrogel scaffold. According to the technical scheme, the method comprises adding a mixed solution of SA / PVA into gaseous silica to produce thixotropic sol, using an obtained product as a printing material to produce a sol scaffold by 3D printing, freezing the sol scaffold to initiate polymerization of polymer PVA (polyvinyl acetate), fully crosslinking into a single network to produce a preformed gel scaffold, removing to thaw at room temperature, and soaking the preformed gel scaffold in CaCl2 aqueous solution so that SA is fully crosslinked into another gel network to produce the hydrogel scaffold. The method is simple, the production process is short, controlling is simple, production cost is low, the scaffold has good reliability, and the 3D printing method of the sodium alginate / polyvinyl chloride all-physically-crosslinked double-network hydrogel scaffold produces the hydrogel scaffold that is nontoxic, good in mechanical property, high in water absorption and good in biocompatibility.

Description

technical field [0001] The invention relates to the technical field of 3D printing of polymer materials, in particular to a method for 3D printing sodium alginate / polyvinyl alcohol fully physically cross-linked double-network hydrogel scaffolds. Background technique [0002] The current reconstruction of human tissues and organs has developed from short-life repair to permanent repair and replacement, from simple mechanical fixation to reconstruction of living human tissues, and tissue engineering medicine is expected to enter a new era of manufacturing tissues and organs . 3D printing is a new additive manufacturing method that builds materials into the desired shape of the model layer by layer. Due to the complexity of biological tissue morphology, it is of great significance to prepare hydrogel biomedical tissue engineering materials by 3D printing. Because hydrogels generally have poor mechanical properties, and chemically crosslinked hydrogels also have the disadvanta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/16A61L27/02A61L27/52A61L27/56C08J3/24C08J3/075C08L29/04C08L5/04B33Y10/00B33Y70/00
CPCA61L27/025A61L27/16A61L27/20A61L27/52A61L27/56A61L2430/06B33Y10/00B33Y70/00C08J3/075C08J3/246C08J2329/04C08J2405/04C08L5/04C08L29/04
Inventor 李学锋徐恒龙世军李荣哲程诗昉周沉叶芳琪彭雪银
Owner HUBEI UNIV OF TECH
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