Granules for assisting in radiation resistance in tumor interventional therapy

An interventional therapy and anti-radiation technology, which is applied in the direction of anti-toxic agents, anti-tumor drugs, and medical raw materials derived from fungi, can solve problems such as immaturity and human hazards, reduce physical damage, weaken radiation, and improve resistance. effect of ability

Inactive Publication Date: 2016-12-07
张晓莉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Interventional therapy has developed rapidly in recent years, which has brought great advances in the treatment and research of human diseases and solved many problems in clinical medicine, but it also has its drawbacks. Due to its long-term fluoroscopy and a large number of photographs , the radiation dose generated is greater than other radiation examinations, which will inevitably cause certain harm to the human body, but the current research on this aspect is not yet mature enough, so a drug that can assist in reducing its radiation damage during interventional therapy is needed, which is the invention. to study

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The auxiliary anti-radiation granule used for tumor interventional therapy is mainly composed of the following components by weight: 4.3 parts of Berberamine hydrochloride, 3.8 parts of cyanidin, 3.2 parts of formononetin, galacturonic acid 2.7 parts, 2.4 parts of apigenin, 2.2 parts of anisene, 1.9 parts of beta-carotene, 1.6 parts of Yunzhi intracellular glycopeptide, 1.4 parts of alizarin, 1.2 parts of D-mannitol, 1.0 parts of coumarin compounds, white fungus 0.9 part of polysaccharide, 0.005 part of riboflavin, 0.002 part of vitamin E, 0.001 part of vitamin C, 10 parts of filler, 6 parts of binder, 1 part of disintegrant, 0.5 part of solubilizer, and 0.2 part of lubricant.

[0017] Among them, the coumarin compound is a coumarin dimer or acridone-coumarin dimer, which is a new compound isolated from the root and root bark of citrus, and has good The anti-cancer effect has a good inhibitory effect on substances that may cause cancer; the filler is: microcrystalline c...

Embodiment 2

[0022] The auxiliary anti-radiation granules used in tumor interventional therapy are mainly composed of the following components by weight: 6.9 parts of Berberamine hydrochloride, 6.4 parts of cyanidin, 5.8 parts of formononetin, galacturonic acid 5.1 parts, 4.7 parts of apigenin, 4.2 parts of anisene, 3.9 parts of beta-carotene, 3.45 parts of Yunzhi intracellular glycopeptide, 3.1 parts of alizarin, 2.7 parts of D-mannitol, 2.4 parts of coumarin compounds, white fungus 2.2 parts of polysaccharide, 0.012 part of riboflavin, 0.008 part of vitamin E, 0.006 part of vitamin C, 20 parts of filler, 16 parts of binder, 4 parts of disintegrant, 1.0 part of solubilizer, and 0.5 part of lubricant.

[0023] Among them, the coumarin compound is a coumarin dimer or acridone-coumarin dimer, which is a new compound isolated from the root and root bark of citrus, and has good The anti-cancer effect has a good inhibitory effect on substances that may cause cancer; the filler is: microcrystall...

Embodiment 3

[0028] The auxiliary anti-radiation granules used for tumor interventional therapy are mainly composed of the following components in parts by weight: 9.5 parts of Berberamine hydrochloride, 9.0 parts of cyanidin, 8.4 parts of formononetin, galacturonic acid 7.5 parts, 7.0 parts of apigenin, 6.6 parts of anisene, 5.9 parts of beta-carotene, 5.3 parts of Yunzhi intracellular glycopeptide, 4.8 parts of alizarin, 4.2 parts of D-mannitol, 3.8 parts of coumarin compounds, white fungus 3.5 parts of polysaccharide, 0.019 part of riboflavin, 0.014 part of vitamin E, 0.011 part of vitamin C, 30 parts of filler, 26 parts of binder, 7 parts of disintegrant, 1.5 part of solubilizer, and 0.8 part of lubricant.

[0029] Among them, the coumarin compound is a coumarin dimer or acridone-coumarin dimer, which is a new compound isolated from the root and root bark of citrus, and has good The anti-cancer effect has a good inhibitory effect on substances that may cause cancer; the filler is: micr...

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PUM

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Abstract

The invention discloses granules for assisting in radiation resistance in tumor interventional therapy. The granules for assisting in radiation resistance in tumor interventional therapy are mainly prepared from berbamine hydrochloride, centaureidin, formononetin, galacturonic acid, apigenin, anethene, beta-carotene, polystictus glycopeptide, alizarin, D-mannitol, a coumarin compound, tremella polysaccharide, riboflavin, vitamin E, vitamin C, a filling agent, a bonding agent, a disintegrating agent and a lubricating agent. According to research on the radiation problem generated in tumor interventional therapy, multiple active ingredients are in a rational proportion, and thus the effects of promoting immunoregulation of the body, reducing harm of radioactive substances to the body, weakening adverse drug reaction and enhancing resistance are achieved; anti-tumor ingredients of the granules have an adjuvant therapy effect on diseases, and thus a patient can recover as soon as possible.

Description

technical field [0001] The invention relates to the technical field of radiopharmaceuticals, in particular to an auxiliary anti-radiation granule used for tumor interventional therapy. Background technique [0002] Interventional therapy is an emerging treatment method between surgery and medical treatment, including endovascular interventional and non-vascular interventional therapy. After more than 30 years of development, it is now called the three pillar disciplines together with surgery and internal medicine. To put it simply, interventional therapy is to make tiny channels with a diameter of several millimeters in blood vessels and skin, or through the original pipeline of the human body, in the case of imaging equipment (angiography machine, fluoroscopy machine, CT, MR, etc.) without exposing the lesion. , B-ultrasound) under the guidance of the minimally invasive treatment method for local treatment of the lesion. Interventional therapy is characterized by small tra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61K31/715A61K31/7012A61K31/525A61K31/4748A61K31/473A61K31/375A61K31/37A61K31/355A61K31/352A61K31/122A61K31/085A61K31/047A61K9/16A61P35/00A61P39/00A61P3/02A61P37/04
CPCA61K31/4748A61K9/1652A61K31/047A61K31/085A61K31/122A61K31/352A61K31/355A61K31/37A61K31/375A61K31/473A61K31/525A61K31/7012A61K31/715A61K36/07A61K36/752A61K38/02A61K2300/00
Inventor 张晓莉
Owner 张晓莉
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