Hydrophobic-substrate-containing AIDS-diagnosis multichannel microfluidic chip device

Abstract

The invention relates to a hydrophobic-substrate-containing AIDS-diagnosis multichannel microfluidic chip device, and belongs to the field of analytical testing. A technical obstacle exists in the manufacture of a substrate of an AIDS-diagnosis microfluidic chip using cheap and easy-to-process polydimethylsiloxane(PDMS), surface of the PDMS is strongly-hydrophobic, the effect of targeted surface modification or surface finish is difficult to last, and the hydrophobic-substrate-containing AIDS-diagnosis multichannel microfluidic chip device aims to solve the series of relevant problems. Main points of the hydrophobic-substrate-containing AIDS-diagnosis multichannel microfluidic chip device are as follows: the PDMS with original ecological surface is selected as the substrate, a hinge-type fixture is manually fastened and positioned in a position near a sample flow terminal of the microfluidic chip to reduce interfacial tension by ultrasonic wave, wherein a miniature ultrasonic transducer is attached to the hinge-type fixture, meanwhile by use of strong ultrasonic wave absorption ability of the PDMS, a rapid ultrasonic wave intensity decline in a short distance can be achieved, so that interfacial tension difference can be formed at both ends of the chip, and a sample flow is facilitated to flow along an originally-hydrophobic capillary channel to the direction of the terminal.

Description

technical field [0001] The invention relates to a multi-channel microfluidic chip device for AIDS diagnosis comprising a hydrophobic substrate, which belongs to the field of analysis and testing. Background technique [0002] For the background of multi-channel microfluidic AIDS diagnosis technology, please refer to CN 200910151219.0 and other invention patent applications. [0003] As far as the overall overview of microfluidic technology itself is concerned, you can refer to the monograph "Illustrated Microfluidic Chip Laboratory" published by the famous microfluidic expert Mr. Lin Bingcheng not long ago, which has been published by Science Press. The past, present, and future prospects of microfluidic technology, etc., have detailed and long-form discussions that go deep into specific details. [0004] So, let's talk about the key issues of this case. [0005] The basic structure of a microfluidic chip includes a substrate etched with tiny liquid flow channels and a cov...

AI Technical Summary

Problems solved by technology

[0007] But it's not that simple

[0008] First, this polydimethylsiloxane material, the material referred to by the acronym PDMS, is itself a strongly hydrophobic material. Microchannels are built on this material. If the microchannels are not targeted The modification operation of the surface of the channel, then, after the overall assembly is completed, that is, after the cover is covered, because the inner surface of the micro channel in the structure occupies most of the inner surface of the liquid flow channel, then the PDMS micro channel The strong hydrophobic characteristic of the inner surface of the channel is the decisive factor, which will make it very difficult for the polar liquid flow similar to the aqueous solution to pass through, and its flow resistance is so large that even ordinary micropumps are difficult to push. Of course, If the cover sheet also chooses to use the PDMS material, then the problem is basically the same, with little difference; therefore, in the prior art, it is necessary to modify and modify the inner surface of the microchannel on the PDMS material; then , is this modification operation for the inner surface of the PDMS microchannel very troublesome? That's not the problem. What constitutes a serious technical problem is another problem: the PDMS polymer molecules in the bulk phase of the PDMS material substrate have the characteristics of automatic diffusion and migration to the surface. The characteristics of polymer molecules automatically diffusing and migrating to the surface will make the modified state of the inner surface of the microchannel modified by the surface modification unable to maintain for a long enough time, and the microgroove after surface modification The maintenance time of the inner surface state of the channel is roughly only enough to complete the time required for the internal test experiment in the laboratory; The surface state of the surface does not last long, but quickly tends to or changes back to the surface state before the surface modification, and returns to the original strongly hydrophobic surface state in a short period of time. Then, just imagine, Can such microfluidic chips be produced in large quantities, stored in large quantities, and widely promoted? The answer is obvious, that is, impossible

This problem has also existed for many years, and so far, it has not been properly solved

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