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Antibacterial polymer and material prepared therefrom and use thereof

A polymer and antibacterial agent technology, applied in the field of antibacterial polymers, can solve the problems of premature release peak, weak binding force, inconvenient use, etc., and achieve the effect of safe synthesis and easy synthesis

Inactive Publication Date: 2016-11-23
福州维亚多国际贸易有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method obtains silicone material, which is combined with chlorhexidine through adsorption, and the binding force is mainly intermolecular force, that is, van der Waals force. This binding force is extremely weak, resulting in a rapid release rate when it is released. , and then decreased rapidly, causing the concentration of chlorhexidine in the surrounding solution to be high when the silicone material was used, but decreased quickly, and the slow-release effect was very poor
And in the body fluid environment, the drug is extremely easy to be dissolved, causing the release peak to appear prematurely and immediately decrease suddenly
In the process of preparing antibacterial polymers by immersion method, the immersion time is as long as 24 or even 48 hours, which is not convenient to use
Moreover, this antibacterial polymer prepared by soaking and absorbing antibacterial agents can easily peel off the antibacterial agents on the surface during packaging and transportation and when instruments such as catheters are inserted into the body.

Method used

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  • Antibacterial polymer and material prepared therefrom and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The polyurethane containing chlorhexidine is prepared through the following steps:

[0038] A. In the reactor, heat and melt PCL at 70°C under vacuum ( 300g ） , keep for 3 hours;

[0039] B. After cooling down to 65°C, add DMSO (180ml), THDL (31.54g) and catalyst Bi348 ( 12.5g ） , maintaining a heating temperature of 65°C under a nitrogen-protected environment, and continuously stirring for 4 hours;

[0040] C. the DMSO solution of chlorhexidine (0.37g / ml, total 120ml DMSO ） Add it into the reactor and keep stirring at a temperature of 65°C for 17 hours;

[0041] D. Add methanol to the reactor (50ml, the ratio is 1ml methanol per 0.17g PCL ） , stirred at 65°C for 1 hour;

[0042] E. After the liquid in the reactor is cooled to room temperature, add dropwise in ether (2000ml), stir;

[0043] F. Heat-dissolve the polymer in the reactor in isopropanol (100~150ml), then add 300ml of EDTA solution (preparation method: dissolve 50g EDTA into 800ml deionized water, add...

Embodiment 2

[0049] The polyurethane containing chlorhexidine gluconate is prepared through the following steps:

[0050] A. In the reactor, heat and melt PCL300g at 70°C under vacuum environment, and keep it for 2 hours;

[0051] B. After cooling down to 60°C, add DMSO (180ml), THDL (31.54g) and catalyst Bi348 (12.5g) into the reactor under nitrogen atmosphere, keep the heating temperature at 60°C under nitrogen protection, and keep stirring 4 hours;

[0052] C. Add the DMSO (120ml) solution of 44.89g of chlorhexidine gluconate into the reactor, and keep stirring at a temperature of 60°C for 12 hours

[0053] D. add methanol (50ml) in the reactor, stir at 60 ℃ for 1 hour;

[0054] E. After the liquid in the reactor is cooled to room temperature, add dropwise in ether (2000ml), stir;

[0055] F. Heat the polymer in the reactor into isopropanol (100-150ml), then add 300ml of EDTA solution (see Example 1 for the configuration method), add 3000ml of deionized water after the reaction, and ...

Embodiment 3

[0061] The polyurethane containing chlorhexidine gluconate is prepared through the following steps:

[0062] A. In the reactor, heat and melt PCL300g at 70°C under vacuum environment, and keep it for 2 hours;

[0063] B. keep at 70 ℃, add DMSO (180ml), THDL (31.54g) and catalyst Bi348 ( 12.5g ） , keep the heating temperature at 70° C. under the environment of nitrogen protection, and keep stirring for 4 hours.

[0064] C. the DMSO (120ml) solution of chlorhexidine gluconate 44.89g is added in the reactor, and the temperature of maintaining 70 ℃ was stirred for 30 hours;

[0065] D. Add 50ml of methanol to the reactor and stir at 70°C for 1 hour;

[0066] E. After cooling the liquid in the reactor to room temperature, add it dropwise into 3000ml of diethyl ether, and stir;

[0067] F. Heat-dissolve the polymer in the reactor in 100-150ml of isopropanol, then add 300ml of EDTA solution (see Example 1 for the configuration method), add 3000ml of deionized water after the reac...

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Abstract

The invention discloses an antibacterial polymer and a product prepared therefrom and use thereof. An antibacterial agent in the antibacterial polymer with chlorhexidine slow-release function and a polymer are mainly hydrogen-bonded, the antibacterial polymer is prepared by a method as follows: during the preparation process of the polymer, the antibacterial agent such as chlorhexidine is added in the stage of formation of a polymer intermediate; the antibacterial polymer also can be prepared by a method as follows: the antibacterial agent is added after the polymer is melted by heating. The antibacterial polymer can be used for preparing plastic materials, rubber materials, textile materials, non-woven materials, oxygen masks, medical dressings or surgical sutures, and has the characteristics of high efficiency, slow release, long effic, broad spectrum, nontoxicity, safety, no stimulation, low cost of synthesis, easy synthesis and secondary use and so on.

Description

technical field [0001] The invention relates to an antibacterial polymer, a material prepared by using the antibacterial polymer and its application. Background technique [0002] At present, plastic and rubber polymer products are widely used in various fields, especially in the medical field. Except for metal and glass materials, all medical products are polymer materials. Due to contact with patients' blood, body fluids, etc., any built-in and external-use medical materials are contaminated by bacteria, which brings the risk of infection to patients. [0003] Preparation of polymers with antibacterial function is one of the ways to reduce and avoid infection. An ideal antibacterial material should have the characteristics of high efficiency, slow release, long-acting, broad-spectrum, non-toxic, safe and non-irritating, and low synthesis cost, easy synthesis and reusable. [0004] Common antibacterial polymers are divided into inorganic antibacterial polymers and organic...

Claims

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Application Information

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IPC IPC(8): C08G18/42C08G18/08C08K5/31
Inventor 瞿国伟陈汉杰顾梵
Owner 福州维亚多国际贸易有限公司
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