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Application of fructus lycii extract to preparation of medicine for preventing and treating senile dementia

A wolfberry extract and a technology of the wolfberry are applied to the preparation of the Chinese medicinal material wolfberry extract and its pharmaceutical preparation, the application in health care products, and the field of medicine, which can solve the problem that the effect is not very satisfactory, and the long-term curative effect and toxic and side effects are not acceptable. Optimism and other issues, to achieve the effects of regulating monoamine neurotransmitter metabolism, controllable drug quality, and improving learning and memory

Inactive Publication Date: 2016-11-23
NANJING HAIHENG MEDICINE SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although countries around the world have invested a lot of money in the research and development of drugs for the treatment of Alzheimer's disease, the effect is not very satisfactory
Most varieties have a certain therapeutic effect and can improve the cognitive function of patients in the short term, but the long-term efficacy and side effects are not optimistic

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation technology of wolfberry fruit extract

[0030] The Chinese herbal medicine Lycium barbarum is washed, dried, and coarsely powdered for CO 2 Supercritical extraction, entrainer 65% ethanol, extraction pressure 25Mpa, extraction temperature 50°C, extraction time 4h, solid-liquid ratio 1:0.5 (g / m1), extract concentrated under reduced pressure, spray-dried and pulverized.

Embodiment 2

[0031] Example 2 oral tablet

[0032] Lycium barbarum extract 0.05~0.2g / tablet

[0033] Sodium carboxymethyl starch 0.01~0.02 g / tablet

[0034] Microcrystalline cellulose 0.1~0.2g / piece

[0035] Magnesium stearate 0.001~0.003g / tablet

[0036] Mix wolfberry fruit extract with sodium carboxymethyl starch and microcrystalline cellulose, sieve, mix well, add appropriate amount of 50% ethanol to granulate, after drying, granulate, add appropriate amount of magnesium stearate, and then use Punches of appropriate diameter compress the granules into tablets.

Embodiment 3

[0037] Example 3 hard capsule

[0038] Lycium barbarum extract 0.05~0.2g / tablet

[0039] Microcrystalline cellulose 0.1~0.2g / piece

[0040] Magnesium stearate 0.001~0.003g / tablet

[0041] Mix wolfberry fruit extract with microcrystalline cellulose, sieve, mix evenly, add appropriate amount of 50% ethanol to granulate, after drying, granulate, add appropriate amount of magnesium stearate, and pack the mixture with a suitable device into hard gelatin capsules.

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Abstract

The invention relates to a traditional Chinese medicinal material fructus lycii extract, a preparation method of medicine preparation of the traditional Chinese medicinal material fructus lycii extract, and application of the fructus lycii extract to preparation of a medicine and a health care product which can prevent and treat senile dementia. An experiment shows that the traditional Chinese medicinal material fructus lycii extract can obviously improve the dysmnesia of an animal pattern and enhance the learning ability, has various effects of effectively improving and adjusting the central cholinergic nerve, adjusting free-radical metabolism and the like, and has a definite treating effect on various senile dementia diseases such as Alzheimer's disease and vascular dementia.

Description

technical field [0001] The invention relates to a medicine for preventing and treating senile dementia and a preparation method thereof, in particular to a preparation method of Chinese medicinal material Lycium barbarum extract and its pharmaceutical preparations, which are used in the preparation of medicines and health products for preventing and treating senile dementia application. Background technique [0002] Alzheimer's disease is a primary degenerative disease of the central nervous system, with a slow onset and a chronic course, with an average of 5 to 10 years, characterized by comprehensive progressive dementia. Its main clinical phase is dementia syndrome, which mainly manifests as high-level neural activity disorders such as memory, language, judgment, cognition, thinking, behavior, personality, and emotion, accompanied by aphasia, apraxia, agnosia, agraphia, and dyslexia. Alzheimer's disease can be divided into Alzheimer's dementia, cerebrovascular dementia, ...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P25/28
Inventor 不公告发明人
Owner NANJING HAIHENG MEDICINE SCI & TECH CO LTD
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