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Traditional Chinese medicinal compound thermosensitive hydrogel for treating oral ulcer

A compound temperature sensitive gel, oral ulcer technology, applied in the directions of pharmaceutical formulations, drug combinations, drug delivery, etc., to achieve the effects of mature technology, prolonged action time, and enhanced therapeutic effect

Inactive Publication Date: 2016-11-23
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These preparations have good curative effects in the treatment of oral ulcers, but their curative effects still have a large room for improvement. The development of a thermosensitive gel for the treatment of oral ulcers with better curative effects will have huge social and market value

Method used

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  • Traditional Chinese medicinal compound thermosensitive hydrogel for treating oral ulcer
  • Traditional Chinese medicinal compound thermosensitive hydrogel for treating oral ulcer
  • Traditional Chinese medicinal compound thermosensitive hydrogel for treating oral ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A traditional Chinese medicine compound temperature-sensitive gel for treating oral ulcer disease, the formula is as follows (per 10g of gel).

[0022]

[0023] The preparation method is as follows: measure the required purified water and place it in an ice-water bath on a magnetic stirrer, slowly add accurately weighed poloxamer 407 and PEG6000 while stirring, and when the poloxamer 407 particles are soaked in water Then pour it into a weighed conical flask, and store it in the refrigerator until a clear, lump-free, and evenly dispersed solution is obtained. Add 0.95ml medicinal material extract and 0.05g borneol medicinal material to the solution, weigh the net weight of the gel, add purified water to make up the weight (10g), and stir evenly.

[0024] Determination of gelation temperature: Using the rotor method, put 5 g of the prepared temperature-sensitive gel sample into a vial, and insert a thermometer into the gel solution. Place the vial on a heatable magne...

Embodiment 2

[0028] A traditional Chinese medicine compound temperature-sensitive gel for treating oral ulcer disease, the formula is as follows (per 10g of gel).

[0029]

[0030] The preparation method is as follows: measure the required purified water and place it in an ice water bath on a magnetic stirrer, slowly add accurately weighed poloxamer 188, PEG6000, HMPC while stirring, when the poloxamer 188 particles are After soaking with water, pour it into a weighed conical flask, and store it in the refrigerator until a clear, lump-free, and evenly dispersed solution is obtained. Add 0.9ml medicinal material extract and 0.1g borneol medicinal material to the solution, weigh the net weight of the gel, add purified water to make up the weight (10g), and stir evenly.

Embodiment 3

[0032] A traditional Chinese medicine compound temperature-sensitive gel for treating oral ulcer disease, the formula is as follows (per 10g of gel).

[0033]

[0034] The preparation method is as follows: measure the required purified water and place it in an ice-water bath on a magnetic stirrer, slowly add accurately weighed poloxamer 407, PEG6000, carbomer 934 and glycerin while stirring, when the poloxamer The sham granules are soaked with water and poured into a weighed conical flask, and stored in a refrigerator until a clear, lump-free, and evenly dispersed solution is obtained. Add 0.9ml medicinal material extract and 0.1g borneol medicinal material to the solution gel, weigh the net weight of the gel, add purified water to make up the weight (10g), and stir evenly.

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PUM

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Abstract

The invention discloses a traditional Chinese medicinal compound thermosensitive hydrogel for treating oral ulcer. The traditional Chinese medicinal compound thermosensitive hydrogel is prepared from the following raw materials in percentage by weight: 17 to 35 percent of a matrix, 5 to 30 percent of a medicinal material and medicinal material extracting solution and the balance of a solvent, wherein the medicinal material and medicinal material extracting solution is prepared from an indigo naturalis extracting solution, a galla chinensis nut extracting solution and an auxiliary medicinal material; the auxiliary medicinal material is one or a combination of a rhizoma bletillae extracting solution and borneolum syntheticum. According to the traditional Chinese medicinal compound thermosensitive hydrogel, the thermosensitive hydrogel is prepared from four traditional Chinese medicaments, i.e. indigo naturalis, galla chinensis nut, rhizoma bletillae and the borneolum syntheticum, which form a basic formula, and is applied in a solution state, that is, a phase change semisolid preparation is formed at a part subjected to drug administration, so that the effects of prolonging the contact time of the medicament and oral mucosa, reducing the burst release effect, slowly releasing the medicament, enhancing absorption and prolonging the acting time are achieved, healing of the surface of a wound can be accelerated, and recurrent oral ulcer can be effectively treated; a process is mature, and the thermosensitive hydrogel is easy to industrially produce; only water and ethanol are adopted as extraction solvents in a preparation process, so that environmental pollution is avoided.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine compound temperature-sensitive gel for treating oral ulcer diseases. Background technique [0002] Recurrent Aphthous Ulcers (Recurrent Aphthous Ulcers, RAU), also known as recurrent aphthous stomatitis, recurrent oral ulcers, recurrent aphthous ulcers, is a disease with the highest incidence rate in oral ulcer diseases. Round or oval superficial ulcers in the non-keratinized area of ​​the oral mucosa are characterized by burning pain, recurrence, and self-limitation. The incidence rate is about 20%, and it can be as high as 66% in certain populations. The pathogenesis of recurrent aphthous ulcer may be related to many factors, but its fundamental etiology and pathogenesis have not been fully clarified, so there is still no cure. For the treatment of this disease, there is no specific drug available, and the long-term effect o...

Claims

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Application Information

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IPC IPC(8): A61K36/195A61K36/704A61K36/315A61K36/898A61K9/06A61P1/02A61K35/64A61K31/045
CPCA61K36/195A61K9/006A61K9/06A61K31/045A61K35/63A61K36/315A61K36/704A61K36/898A61K47/10A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 罗永明杨华生张珊珊
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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