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A method for constructing an animal model of Acinetobacter baumannii pneumonia

A technology of Acinetobacter baumannii and animal models, which is applied in the field of medical animal models, can solve the problems of difficult bacterial quantification, interference of experimental results, and animal sneezing reflex when spraying bacterial suspensions, so as to delay bacterial drug resistance and promote human health , the effect of reducing the expenditure of treatment

Active Publication Date: 2019-07-30
湖南斯莱克景达实验动物有限公司
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Problems solved by technology

The advantage is that the method is simple and easy to operate, but the disadvantage is that some parasitic bacteria in the respiratory tract may enter the lower respiratory tract, which will interfere with the experimental results; nasal drip is likely to cause sneezing reflex in animals, and the bacterial suspension is not easy to quantify bacteria, resulting in individual differences; and Nasal instillation has a high concentration of bacterial solution, which is more irritating to the airway mucous membrane than aerosol inhalation

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  • A method for constructing an animal model of Acinetobacter baumannii pneumonia
  • A method for constructing an animal model of Acinetobacter baumannii pneumonia
  • A method for constructing an animal model of Acinetobacter baumannii pneumonia

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[0039] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

[0040] A method for building an animal model of Acinetobacter baumannii pneumonia, comprising the steps of:

[0041] (1) Construct immunosuppressed New Zealand rabbits;

[0042] The detailed steps are as follows: take a healthy New Zealand rabbit, confirm no lung infection by chest X-ray examination, and inject cytarabine 440mg / m2 daily through the ear vein for the first six days 2, once every other day after the 6th day, immunosuppressed New Zealand rabbits were obtained; the characteristics of the immunosuppressed New Zealand rabbits all had: messy hair, dull and mild hair loss, reduced drinking water, food intake and activities, a slight drop in body temperature, and no weight loss. Seeing a significant increase, the blood cell count decreased...

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Abstract

The invention discloses a method for establishing an animal model infected with Acinetobacter baumannii pneumonia. The method comprises the following steps: (1) preparing an immunosuppressive New Zealand rabbit; (2) preparing an Acinetobacter baumannii solution; (3) infecting the animal and establishing the model. The simple, rapid and efficient animal model infected with Acinetobacter baumannii pneumonia is established to help people research production and development processes of drug resistance of Acinetobacter baumannii and drug resistance related mechanisms of the Acinetobacter baumannii, assistance is provided for delaying of drug resistance of bacteria and better treatment of infection with the Acinetobacter baumannii, expense for related treatment of patients can be reduced, and human health can be promoted.

Description

technical field [0001] The invention relates to the technical field of medical animal models, in particular to a method for constructing an animal model of Acinetobacter baumannii pneumonia. Background technique [0002] In recent years, domestic and foreign reports on Acinetobacter baumannii have gradually increased. According to Keen and Robinson's report, the detection rate of Acinetobacter baumannii ranks first, as high as 53%. Studies by Mendes et al. have shown that the detection rate of Acinetobacter has been increasing year by year in recent years, and infections caused by Acinetobacter baumannii account for 80%-90% of Acinetobacter. In 2013, China CHINET Bacterial Resistance Surveillance showed that the detection rate of Acinetobacter baumannii in the hospital was as high as 11.97%, ranking third among all Gram-negative bacteria, and showing a trend of high drug resistance and multi-drug resistance , the resistance rates to imipenem and meropenem were 62.8% and 59...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K31/7068
CPCA61K31/7068A61K35/74
Inventor 黄辉周建党朱颉万齐全易琦峰蒲虹妃
Owner 湖南斯莱克景达实验动物有限公司
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