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Preparation method of oxidized cellulose nanofiber membrane sheet with fast bleeding stopping function

A technology of nanofiber membrane and oxidized cellulose, applied in the field of medical materials, can solve the problems of slow hemostasis rate, etc., and achieve the effects of mild reaction, convenient processing and high selectivity

Active Publication Date: 2016-11-16
广州永翔科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem of slow hemostasis rate in existing oxidized cellulose hemostatic materials, and provide a preparation method of oxidized cellulose nanofiber membrane with rapid hemostasis function

Method used

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  • Preparation method of oxidized cellulose nanofiber membrane sheet with fast bleeding stopping function
  • Preparation method of oxidized cellulose nanofiber membrane sheet with fast bleeding stopping function
  • Preparation method of oxidized cellulose nanofiber membrane sheet with fast bleeding stopping function

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Cellulose acetate was used as raw material and dissolved in DCM / DMF mixed solvent to prepare a solution with a mass fraction of 11%, wherein the mass ratio of DCM to DMF was 2:1. Add this solution to the liquid tank of the electrospinning equipment, set the voltage of the DC high-voltage generator to 45kV, and the receiving distance between the electrode and the substrate to be 200mm, and a film (structural Such as figure 1 shown), the film was washed several times with deionized water and then vacuum-dried for further use. The cellulose acetate nanofiber film is immersed in NaOH / ethanol-water solution with a concentration of 0.1mol / L for hydrolysis, wherein the mass ratio of ethanol to water is 1:4, the reaction time is 24 hours, and washed with deionized water after the reaction Vacuum drying after many times to obtain cellulose nanofiber film (structure such as figure 2 shown). Weigh 0.1g of NaBr and 0.02g of TEMPO, dissolve them in 100mL of deionized water, plac...

Embodiment 2

[0030]Cellulose acetate was used as raw material and dissolved in acetone / DMAc mixed solvent to prepare a solution with a mass fraction of 12%, wherein the mass ratio of acetone to DMAc was 2:1. Add this solution into the liquid tank of the electrospinning equipment, set the voltage of the DC high-voltage generator to 45kV, and the receiving distance between the electrode and the substrate to be 200mm, and a film made of cellulose acetate nanofibers can be obtained. The film was washed several times with deionized water and dried in vacuum before use. The cellulose acetate nanofiber film is immersed in NaOH / ethanol-water solution with a concentration of 0.1mol / L for hydrolysis, wherein the mass ratio of ethanol to water is 1:4, the reaction time is 24 hours, and washed with deionized water after the reaction Vacuum drying after several times to obtain the cellulose nanofiber film. Weigh 0.03g TEMPO, 2g NaClO 2 Dissolve in phosphate buffer solution with pH 6.8, heat the solut...

Embodiment 3

[0032] Ethyl cellulose was used as raw material and dissolved in ethanol to make a solution with a mass fraction of 15%. Add this solution into the liquid tank of the electrospinning equipment, set the voltage of the DC high-voltage generator to 45kV, and the receiving distance between the electrode and the substrate to be 200mm, and a film made of ethyl cellulose nanofibers can be obtained. The film was washed several times with deionized water and then dried in vacuum. The ethylcellulose nanofiber film was immersed in KOH / ethanol-water solution with a concentration of 0.1mol / L for hydrolysis, wherein the mass ratio of ethanol to water was 1:4, and reacted at 50°C for 24 hours. After the reaction was completed, deionized After washing with water several times, vacuum drying is performed to obtain a cellulose nanofiber film. Weigh 0.1g NaBr and 0.02g TEMPO, dissolve them in 100mL deionized water, place the solution in an ice-water bath, and keep the solution temperature below...

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Abstract

The invention belongs to the technical field of medical materials, and particularly relates to a preparation method of an oxidized cellulose nanofiber membrane sheet with a fast bleeding stopping function. According to the method, cellulose derivatives such as cellulose acetate, cellulose acetate butyrate and ethyecellulose are used as raw materials; a nanofiber membrane of the cellulose derivatives is prepared through an electrostatic spinning process. Then, through processes of hydrolysis, oxidization and the like, the oxidized cellulose nanofiber membrane sheet is obtained. The method has the characteristics that the process is simple; the reaction is mild; safety and environment protection are realized. The oxidized cellulose nanofiber membrane sheet prepared by the method has good biocompatibility and biodegradability; the gathering of blood platelets in a wound can be effectively promoted; the fast bleeding stopping can be realized.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method of an oxidized cellulose nanofiber membrane with rapid hemostasis function. Background technique [0002] Oxidized cellulose, also known as C-6 carboxy cellulose, is a derivative of the selective oxidation of the C-6 primary hydroxyl group of cellulose. Oxidized cellulose has excellent biocompatibility, biosafety and biodegradability, and can be used as hemostatic gauze, surgical sutures, etc. in the medical industry. Currently, the most widely used clinical products are produced by Johnson & Johnson The instant yarn series produced absorbable hemostatic products. [0003] There are two main oxidation systems for cellulose: NO 2 Oxidation system and TEMPO oxidation system. NO 2 The oxidation system can be traced back to 1942 at the earliest, and this system has a high degree of selective oxidation of cellulose primary hydroxyl. Afte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M13/355D06M11/13D06M11/30D06M11/38A61L15/28A61L15/42D01D5/00D04H1/4258D04H1/728D06M101/08
CPCA61L15/28A61L15/42A61L2300/232A61L2400/04D01D5/0092D04H1/4258D04H1/728D06M11/13D06M11/30D06M11/38D06M11/385D06M13/355D06M2101/08
Inventor 赵鹏赵铭文学军
Owner 广州永翔科技发展有限公司
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