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Method for preparing L-glutamic acid chelated potassium monohydrate

A technique for chelating potassium glutamic acid and glutamic acid, which is applied in the field of preparing L-glutamic acid chelating potassium monohydrate, can solve problems such as poor fluidity, high production cost, and difficult control, and achieve improved safety factor, The effect of reducing equipment investment and reducing raw material costs

Inactive Publication Date: 2016-11-16
宜兴市前成生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first method: the use of organic solvents reduces the safety factor of the production environment, and organic solvents are likely to remain in the obtained products, and the use of organic solvents for extraction will increase production costs
At the same time, due to the use of organic solvents in the product drying process, the appearance of the product is dull and poor in fluidity due to the volatilization of the solvent to take away a small amount of crystal water; the second extraction method has equipment, large site investment, and high production costs; the obtained product is powder , no particles and fluidity at all, unstable moisture content, difficult to control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A method for preparing L-glutamic acid chelated potassium monohydrate, comprising the following steps:

[0026] (1) Add water to the reaction kettle, equipped with a motor to stir, heat to a temperature of 75°C, and keep stirring. After adding L-glutamic acid, gradually add potassium carbonate. Potassium carbonate needs to be added slowly to prevent excessive foaming and liquid splashing Out; wherein the quality of L-glutamic acid is 20% of the water quality, and the ratio of the amount of L-glutamic acid to potassium carbonate is 2:1.005.

[0027] After the solution is clarified, take a small amount of the reaction solution to filter and remove impurities, then test the pH, and correct the pH of the reaction solution to 8.0; continue to react at 85°C for 3 hours; then decolorize and filter the reaction solution, and concentrate it in vacuum until the temperature is 37.6°Bé. The concentrate was cooled to a temperature of 18°C.

[0028] (2), add L-glutamic acid chelated...

Embodiment 2

[0030] A method for preparing L-glutamic acid chelated potassium monohydrate, comprising the following steps:

[0031] (1) Add water to the reaction kettle, equipped with a motor to stir, heat to a temperature of 75°C, and keep stirring. After adding L-glutamic acid, gradually add potassium hydroxide. Potassium hydroxide needs to be added slowly to prevent excessive foaming. The liquid is splashed; the mass of L-glutamic acid is 20% of the mass of water, and the mass ratio of L-glutamic acid to potassium hydroxide is 1:1.01.

[0032] After the solution is clarified, take a small amount of the reaction solution to filter and remove impurities, then test the pH, and correct the pH of the reaction solution to 8.0; continue to react at 85°C for 3 hours; then decolorize and filter the reaction solution, and concentrate it in vacuum until the temperature is 37.2°Bé. The concentrate was cooled to a temperature of 18°C.

[0033] (2), add L-glutamic acid chelated potassium monohydrate...

Embodiment 3

[0035] A method for preparing L-glutamic acid chelated potassium monohydrate, comprising the following steps:

[0036] (1) Add water to the reaction kettle, equipped with a motor to stir, heat to a temperature of 75°C, and keep stirring. After adding L-glutamic acid, gradually add potassium carbonate. Potassium carbonate needs to be added slowly to prevent excessive foaming and liquid splashing Out; wherein the mass of L-glutamic acid is 20% of the water mass, and the mass ratio of L-glutamic acid and potassium carbonate is 2:1.005.

[0037] After the solution is clarified, take a small amount of the reaction solution and filter to remove impurities, then test the pH, and correct the pH of the reaction solution to 8.2; continue to react at 85°C for 3 hours; then decolorize and filter the reaction solution, and concentrate it in vacuum until the temperature is 37.6°Bé. The concentrate was cooled to a temperature of 16°C.

[0038] (2) Add L-glutamic acid chelated potassium mono...

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Abstract

The invention discloses a method for preparing L-glutamic acid chelated potassium monohydrate. The method comprises the following steps of performing a reaction by using potassium carbonate or potassium hydroxide, and L-glutamic acid as raw materials, and by using water of which the temperature is 70-80 DEG C as a solvent, clarifying a solution, adjusting the pH value of reaction liquid to 7.5-8.5, continuing a reaction at 80-85 DEG C for 2-4 hours, decoloring reaction liquid, performing filtration, performing concentration to a Baume degree of 36-38 degree Be, and then performing cooling to 15-20 DEG C; and adding L-glutamic acid chelated potassium monohydrate crystals as seed crystals to concentrated liquid, maintaining the temperature to be 15-20 DEG C, performing stirring for crystallization, performing discharging, performing centrifugation so as to obtain crude products, rinsing every 100 kg of the crude products with 5-10 L of deionized water, and drying solids so as to obtain products of which the chelating degree is 95% or above. According to the method disclosed by the invention, an organic solvent is not used, so that the safety coefficient of production environment is increased, and the cost of the raw materials is substantially reduced; the products are free from solvent residues, and moisture is easy to control; and besides, investment on equipment and sites can be reduced.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to a method for preparing L-glutamic acid chelated potassium monohydrate. Background technique [0002] L-glutamic acid chelated potassium monohydrate is a pharmaceutical intermediate, which can be used as a food additive and a biochemical research preparation. Arrhythmia, hepatitis, liver insufficiency and other aspects have a significant effect. The ingredients and concentration of the existing production process are exactly the same, and the difference is mainly the difference in the extraction method. The current production process for extracting L-glutamic acid chelated potassium monohydrate is as follows: using an organic solvent to change the polarity of the solvent to precipitate the product or adopting a spray drying method to directly obtain the finished product. The first method: the use of organic solvents reduces the safety factor of the production enviro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/18C07C227/42C07C229/76
CPCC07C227/18C07B2200/13C07C227/42C07C229/76
Inventor 席日新
Owner 宜兴市前成生物有限公司
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