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A contrast agent used for gastrointestinal tract ultrasonic diagnosis, a preparing method thereof and applications of the contrast agent

An ultrasound diagnosis and contrast agent technology, which is applied in echo/ultrasound imaging agents, medical preparations containing active ingredients, antitoxic agents, etc. Easy-to-use effects

Inactive Publication Date: 2016-11-09
陈萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

People have been looking for radiation protective agents for a long time, but an ideal drug has not yet been found for the treatment and prevention of toxic side effects caused by radiation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] In the embodiment of the present invention, a contrast agent for ultrasonic diagnosis of the gastrointestinal tract is composed of the following raw materials in parts by weight: 22 parts of Polygonum japonica, 1 part of stinging sand, 8 parts of golden fruit olive, 10 parts of hibiscus bark, Digupi 18 parts.

[0025] Grind the Polygonum oleifera and Golden Fruit Lavender, pass through a 100-mesh sieve, add 75% ethanol solution with a volume concentration 5 times its mass, heat and stir at 65°C for 55 minutes, then conduct microwave treatment for 40 minutes, microwave power is 500W, and then filter Take the filtrate. Crush the stinging sand, hibiscus bark, and ground bone bark, pass through an 80-mesh sieve, add water 13 times its mass, boil it for 55 minutes, then lower it to 75°C, add vinegar 3 times the mass of the stinging sand, and then put it in Ultrasonic treatment was performed at 75°C for 25 minutes, the ultrasonic power was 800W, and the supernatant was centr...

Embodiment 2

[0027] In the embodiment of the present invention, a contrast agent for ultrasonic diagnosis of the gastrointestinal tract is composed of the following raw materials in parts by weight: 30 parts of Polygonum japonica, 8 parts of stinging sand, 16 parts of golden fruit olive, 18 parts of hibiscus bark, Digupi 26 parts.

[0028] Grind the Polygonum japonica and Golden Fruit Lavender, pass through a 100-mesh sieve, add 75% ethanol solution 6 times its mass, heat and stir at 68°C for 60 minutes, then conduct microwave treatment for 45 minutes at a microwave power of 500W, and then filter to obtain the filtrate. Crush the stinging sand, hibiscus bark, and ground bone bark, pass through an 80-mesh sieve, add water 14 times its mass, boil it for 60 minutes, then lower it to 78°C, add vinegar 4 times the mass of stinging sand, and then Ultrasonic treatment at 78°C for 30 minutes, the ultrasonic power is 800W, and the supernatant liquid after centrifugation. The filtrate was mixed wit...

Embodiment 3

[0030] In an embodiment of the present invention, a contrast agent for ultrasonic diagnosis of the gastrointestinal tract is composed of the following raw materials in parts by weight: 24 parts of Polygonum japonica, 3 parts of stinging sand, 10 parts of golden fruit olive, 12 parts of hibiscus bark, Digupi 20 parts.

[0031] Grind the Polygonum and Golden Fruit Lavender, pass through a 100-mesh sieve, add 5.5 times the mass of 75% ethanol solution, heat and stir at 67°C for 58 minutes, then conduct microwave treatment for 42 minutes at a microwave power of 500W, and then filter to obtain the filtrate. Crush the stinging sand, hibiscus bark, and ground bone bark, pass through an 80-mesh sieve, add water 13.5 times its mass, boil for 58 minutes, then lower it to 76°C, add vinegar 3.5 times the mass of stinging sand, and then Ultrasonic treatment was performed at 76°C for 28 minutes, the ultrasonic power was 800W, and the supernatant was centrifuged. The filtrate was mixed with...

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PUM

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Abstract

A contrast agent used for gastrointestinal tract ultrasonic diagnosis, a preparing method thereof and applications of the contrast agent are disclosed. Raw materials of the contrast agent comprise, by weight, 22-30 parts of polygonum hydropiper L., 1-8 parts of bombyxmori Linnaeus faeces, 8-16 parts of tinospora root, 10-18 parts of golden larch bark and 18-26 parts of Chinese wolfberry root-bark. The method includes a step of crushing the polygonum hydropiper L. and the tinospora root, sieving, adding an ethanol solution having a concentration of 75%, heating, stirring, performing microwave treatment and filtering to obtain a filtrate, a step of crushing the bombyxmori Linnaeus faeces, the golden larch bark and the Chinese wolfberry root-bark, sieving, adding water, decocting with strong fire, adding edible vinegar, performing ultrasonic treatment, and centrifuging for separation to obtain a supernatant, and a step of mixing the filtrate and the supernatant, heating, stirring and drying. The contrast agent under synergistic effects of the raw materials is free of side and toxic effects, convenient to use, stable in physical and chemical properties, obvious in contrast and clear in image, can be used for treating side and toxic effects caused by ray radiation, and is capable of effectively reducing the death rate of mice after being radiated with a lethal amount of rays and improving survival quality. The contrast agent has a synergistic antitumor function with radiation rays and is free of toxic damages to marrow and liver and kidney functions.

Description

technical field [0001] The invention relates to the technical field of Chinese herbal medicine preparations, in particular to a contrast agent for gastrointestinal ultrasound diagnosis and its preparation method and application. Background technique [0002] Ultrasonic examination has the characteristics of no damage to the human body, non-invasiveness, and good repeatability, and is generally welcomed by people. However, the physical properties of ultrasound determine that it is not good at imaging organs with more gas, such as the intestinal tract. This is because sound waves are totally reflective to gases, and mucus with many bubbles in the intestine also interferes with ultrasonic examination, making it difficult to visualize and lacking accuracy in the diagnosis of intestinal lesions. At present, intestinal examination mainly relies on barium enema fluoroscopy and colonoscopy. However, barium enema fluoroscopy needs to be carried out under radiation, which is harmful ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K36/815A61P39/00A61P35/00A61K35/64
CPCA61K49/22A61K35/63A61K36/15A61K36/59A61K36/704A61K36/815A61K2236/331A61K2236/333A61K2236/53A61K2300/00
Inventor 陈萍
Owner 陈萍
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