Novel pharmaceutical composition of compound amino acid injection 18AA-I and application of pharmaceutical composition

A 18AA-I, compound amino acid technology, applied in the directions of drug combination, drug delivery, active ingredients of phosphorus compounds, etc., can solve the problems of low solubility, troublesome preparation, reduced drug safety and convenience or adaptability, etc.

Inactive Publication Date: 2016-10-05
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We found that the injection of the existing compound amino acid injection (18AA-I) in the case of a variety of different diseases, including prone to metabolic acidosis, also has defects or insufficient or unsatisfactory or hidden dangers of varying degrees. In the case of close days or more and more emphasis on individualized treatment, this greatly reduces the safety and convenience or adaptability of medication; when using tyrosine in the preparation of composition solutions, it is relatively difficult to prepare because of its low solubility. Trouble, switching to acetyltyrosine or N-acetyl-L-tyrosine makes it easier to prepare the solution; other salts of this medicine that are different from calcium chloride are beneficial to change the shortcomings of the prior art, including Irritant, etc., provide a new combination of calcium salts, such as calcium glutamate or L-calcium glutamate, or calcium gluconate, or calcium glucoheptonate, or calcium lactate, or calcium acetate, or calcium glycerophosphate, Or calcium fructonate etc., therefore, the present invention provides the new pharmaceutical composition of new novel compound amino acid injection (18AA-I) for clinical, provides the preparation of new pharmaceutical composition, provides new better than existing preparation Pharmaceutical composition preparations not only reduce adverse reactions in different situations, improve clinical treatment effects, provide new options for clinics, and meet clinical needs in different situations

Method used

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  • Novel pharmaceutical composition of compound amino acid injection 18AA-I and application of pharmaceutical composition
  • Novel pharmaceutical composition of compound amino acid injection 18AA-I and application of pharmaceutical composition
  • Novel pharmaceutical composition of compound amino acid injection 18AA-I and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0257] Embodiment 1, the preparation of compound amino acid injection (18AA-I), prescription:

[0258] L-glutamic acid 90 grams;

[0259] L-proline 81 grams;

[0260] L-serine 75 grams;

[0261] L-phenylalanine 55 grams;

[0262] L-leucine 53 grams;

[0263] L-valine 43 grams;

[0264] L-aspartic acid 41 grams;

[0265] L-isoleucine 39 grams;

[0266] L-Lysine acetate 55.3 grams;

[0267] L-arginine 33 grams;

[0268] L-threonine 30 grams;

[0269] L-alanine 30 grams;

[0270] L-histidine 24 grams;

[0271] Glycine 21 grams;

[0272] L-methionine 19 grams;

[0273] L-cysteine ​​1.00 g;

[0274] L-tryptophan 10 grams;

[0275] L-tyrosine 5 grams;

[0276] Potassium D-gluconate 11.9 grams;

[0277] Calcium fructonate dihydrate 7.67 g;

[0278] Magnesium L-aspartate tetrahydrate 5.4 g;

[0279] Sodium hydroxide 20 grams;

[0280] Potassium hydroxide 8.4 grams;

[0281] Sodium metabisulfite 3 grams;

[0282]

[0283] Preparation Process:

[0284]Weigh each...

Embodiment 2

[0285] Embodiment 2, the preparation of compound amino acid injection (18AA-I), prescription:

[0286] L-glutamic acid 90 grams; L-proline 81 grams; L-serine 75 grams; L-phenylalanine 55 grams; L-leucine 53 grams; L-valine 43 grams; L-gate 41 grams of aspartic acid; 39 grams of L-isoleucine; 55.3 grams of L-lysine acetate; 33 grams of L-arginine; 30 grams of L-threonine; 30 grams of L-alanine; 24 grams of histidine; 21 grams of glycine; 19 grams of L-methionine; 1.00 grams of L-cysteine; 10 grams of L-tryptophan; 5 grams of L-tyrosine; 4.98 grams of potassium acetate; Hydrate 11.2 g; L-magnesium aspartate tetrahydrate 5.4 g; sodium hydroxide 20 g; potassium hydroxide 8.4 g; sodium metabisulfite 0.1 g; edetate calcium sodium 0.1 g; tartaric acid 1.5 g;

[0287]

[0288] Preparation process: Weigh each raw material and auxiliary material according to the prescription; add 7500ml of water for injection into the dispensing tank, heat and boil, and repeatedly use vacuum pumping...

Embodiment 3

[0289] Embodiment 3, the preparation of compound amino acid injection (18AA-I), prescription:

[0290] L-glutamic acid 90 grams; L-proline 81 grams; L-serine 75 grams; L-phenylalanine 55 grams; L-leucine 53 grams; L-valine 43 grams; L-gate 41 grams of aspartic acid; 39 grams of L-isoleucine; 55.3 grams of L-lysine acetate; 33 grams of L-arginine; 30 grams of L-threonine; 30 grams of L-alanine; Histidine 24 g; Glycine 21 g; L-Methionine 19 g; L-Cysteine ​​1.00 g; L-Tryptophan 10 g; L-Tyrosine 5 g; Potassium L-Glutamate Monohydrate 10.3 grams; calcium gluconate monohydrate 11.2 grams; L-magnesium aspartate tetrahydrate 5.4 grams; sodium hydroxide 20 grams; potassium hydroxide 8.4 grams; sodium metabisulfite 0.3 grams; edetate calcium sodium 0.03 grams; 0.6 grams of citric acid;

[0291]

[0292] Preparation process: Weigh each raw material and auxiliary material according to the prescription; 1), add the prescription amount, L-potassium glutamate monohydrate, calcium glucon...

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Abstract

The invention provides a new pharmaceutical composition of compound amino acid injection (18AA-I). The pharmaceutical composition of the present invention can be used to prepare patients whose amino acids cannot meet the metabolic needs of the body, such as insufficient protein intake and malabsorption, and improve the nutritional status of patients after surgery, as well as metabolic acidosis, hepatic coma, traumatic brain injury, and hypofunction of the brain. , neurasthenia, epilepsy and other neurological diseases such as the prevention or treatment of drugs, so that the clinical use of the obtained product is more suitable for new populations or better pertinence and better clinical safety.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, it is provided for patients whose amino acids cannot meet the metabolic needs of the body, such as insufficient protein intake and malabsorption. A new pharmaceutical composition of compound amino acid injection (18AA-I) which is also used to improve the nutritional status of patients after surgery, as well as its preparation and use. The product of the present invention is more suitable for patients who need to supplement 18AA-I amino acid injection under many diseases or symptoms such as metabolic acidosis or hyperchloremic metabolic acidosis, and the product of the present invention has wider safety in clinical use Or more or updated indications or adapted populations, etc. Background technique [0002] Protein is the main component of cell structure. The basic unit of protein structure is amino acid. The human body needs to take in a certain amount of protein every day to mee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K33/06A61K33/42A61K31/198A61K31/401A61K31/4172A61K9/08A61P3/02
Inventor 刘力
Owner 刘力
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