Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for determining formaldehyde in electronic cigarette liquid

A technology of e-cigarette liquid and determination method, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of e-cigarette liquid matrix complexity, large difference in matrix, and large difference in additives, and achieve good solubility , prevent aggregation, simple pre-treatment process

Inactive Publication Date: 2016-09-21
ZHENGZHOU TOBACCO RES INST OF CNTC
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, due to the wide variety of e-liquid brand specifications and the large differences in the additives of different flavors of e-liquid, the e-liquid matrix is ​​relatively complex, and the matrix of different e-liquid samples varies greatly

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for determining formaldehyde in electronic cigarette liquid
  • Method for determining formaldehyde in electronic cigarette liquid
  • Method for determining formaldehyde in electronic cigarette liquid

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0031] The standard solution of formaldehyde-2,4-dinitrophenylhydrazone was analyzed by LC-MS / MS. Perform regression analysis on the peak area ratio of the target substance and the internal standard quantitative ion pair and the formaldehyde concentration to obtain the formaldehyde standard working curve and regression equation, and calculate the detection limit (LOD) with 3 times the signal-to-noise ratio (S / N = 3). The results are shown in Table 2:

[0032] Table 2 Test results of formaldehyde standard working solution

[0033] compound

example 2

[0035] The standard addition recovery experiment was carried out at three concentration levels of low, medium and high, and each standard addition level was repeated 6 times. The recovery rate and precision of each addition level were calculated according to the measured amount and the standard addition amount. The specific results are shown in the following table:

[0036] Table 3 method recovery and repeatability

[0037]

example 3

[0039]Weigh 0.2 g of an e-cigarette liquid sample, add 0.6-3.0 mL deionized water, 0.4-3.0 mL DNPH derivatization reagent and 50-500 µL HClO 4 Aqueous solution, shake well, place at room temperature for 30-150 min for derivatization reaction, add 50-500 µL pyridine after the reaction, add 100 µL internal standard working solution, and dilute to 10 mL with acetonitrile, shake well, pass through 0.22 µm organic phase filter membrane, into LC-MS / MS analysis.

[0040] The peak area ratio of the target substance and the internal standard quantitative ion pair was substituted into the regression equation, and the formaldehyde content in the sample was calculated to be 0.47 µg / g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a rapid analysis method for determining formaldehyde in electronic cigarette liquid. The method comprises the following steps that firstly, a dispersant is added to an electronic cigarette liquid sample, then a DNPH derivatization reagent and an acid solution are added to perform derivatization reaction, an alkaline reagent and an internal standard substance are added, and finally the formaldehyde content in the electronic cigarette liquid is determined through LC-MS / MS analysis. The method is high in sensitivity, strong in anti-interference performance and good in repeatability, the pretreatment process is simple and rapid, and the method is suitable for detection of electronic cigarette liquid samples on a large scale.

Description

technical field [0001] The invention relates to a rapid analysis and determination method for formaldehyde in electronic cigarette liquid, belonging to the technical field of trace analysis. Background technique [0002] Formaldehyde, also known as formaldehyde, is a colorless, highly irritating gas at room temperature. Formaldehyde is a moderately toxic substance, LD 50 800 mg / kg (rat oral); 60~120 mg / m 3 Severe damage to the bronchi and lungs occurs 5 to 10 minutes after inhalation. The oral lethal dose is about 10-20 mL. Acute formaldehyde poisoning is a systemic disease mainly based on eye, respiratory system and central nervous system damage. Long-term exposure to low-concentration formaldehyde vapor may cause headaches, weakness and other symptoms. A large number of studies have shown that formaldehyde is mutagenic and carcinogenic, and the International Agency for Research on Cancer (IARC) has listed it as a Class 1 human carcinogen. [0003] In recent years, w...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N30/06G01N30/88
CPCG01N30/06G01N30/88G01N2030/027G01N2030/067
Inventor 潘立宁赵乐余晶晶刘克建陈黎樊美娟刘绍锋吕芳贾云祯刘惠民孟庆华
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com