Process for large-scale preparation of pravastatin sodium D-type crystal
A technology of pravastatin sodium and a process is applied in the field of large-scale preparation of pravastatin sodium D-type crystals, and can solve the problems of yellowish color of pravastatin sodium D-type crystals, low crystal transformation efficiency, and unsuitability for industrial scale-up. , to achieve the effect of simple and easy process, high crystal form conversion rate and simple preparation method
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Embodiment 1
[0030] The preparation of embodiment 1 pravastatin sodium type D crystal
[0031] S1: Take pravastatin sodium crystals, add butanol with a water content of 5% at a liquid-solid ratio of 0.1mL / g at a temperature of 12°C, and ultrasonically mix for 8 minutes at an ultrasonic power of 750W to prepare into a mixed slurry;
[0032] S2: Put the mixed slurry described in S1 in a vacuum drying oven, raise the temperature to 65°C, and pass high-purity nitrogen gas for 12 hours while vacuuming, and keep the vacuum value at -0.40MPa;
[0033] S3: Stop feeding high-purity nitrogen, keep the temperature at 60°C, adjust the vacuum value to -1.0MPa, and dry for 12 hours to obtain the product.
[0034] The prepared product is a white crystal, and its PXRD spectrum is as follows: figure 1 As shown, there are obvious characteristic peaks at diffraction angles 2θ°=3.8, 6.5, 9.8 and 17.0°, which are pravastatin sodium type D crystals, and it can be clearly seen from the PXRD pattern that except...
Embodiment 2
[0035] The preparation of embodiment 2 pravastatin sodium type D crystals
[0036] S1: Take pravastatin sodium crystals, and add an equal volume of acetone and propanol mixed organic solvent with a water content of 3% at a liquid-solid ratio of 0.12mL / g at a temperature of 10°C. Under the condition of 500W, ultrasonically mix for 10min to make a mixed slurry;
[0037]S2: Put the mixed slurry described in S1 in a vacuum drying oven, raise the temperature to 70°C, and pass high-purity nitrogen gas for 10 hours while vacuuming, and keep the vacuum value at -0.90MPa;
[0038] S3: Stop feeding high-purity nitrogen, keep the temperature at 50°C, adjust the vacuum value to -0.95MPa, and dry for 12h to obtain the product.
[0039] The prepared product is a white crystal, and its PXRD spectrum is as follows: figure 2 As shown, there are obvious characteristic peaks at diffraction angles 2θ°=3.7, 6.4, 9.8 and 16.9°, which is a D-type crystal of pravastatin sodium, and it can be clear...
Embodiment 3
[0040] Embodiment 3 Preparation of pravastatin sodium D-type crystal
[0041] S1: Take pravastatin sodium crystals, add propanol with a water content of 10% at a liquid-solid ratio of 0.08mL / g at a temperature of 10°C, and ultrasonically mix for 6 minutes at an ultrasonic power of 600W to prepare into a mixed slurry;
[0042] S2: Put the mixed slurry described in S1 in a vacuum drying oven, raise the temperature to 50°C, and pass high-purity nitrogen gas for 15 hours while vacuuming, and keep the vacuum value at -0.60MPa;
[0043] S3: Stop feeding high-purity nitrogen, keep the temperature at 70°C, adjust the vacuum value to -1.0MPa, and dry for 15 hours to obtain the product.
[0044] The prepared product is a white crystal, and its PXRD spectrum is as follows: image 3 As shown, there are obvious characteristic peaks at diffraction angles 2θ°=3.8, 6.4, 9.8 and 16.9°, which are pravastatin sodium type D crystals, and it can be clearly seen from the PXRD pattern that in addi...
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