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Detection method of compound Houttuynia cordata syrup drug

A technology of compound Houttuynia cordata and quality inspection method, which is applied in the direction of drug combination, measuring device, medical formula, etc., and can solve the problem of no specific drug and so on

Active Publication Date: 2017-04-05
HEILONGJIANG ZHONGGUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug for MsPGN in modern medicine

Method used

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  • Detection method of compound Houttuynia cordata syrup drug
  • Detection method of compound Houttuynia cordata syrup drug
  • Detection method of compound Houttuynia cordata syrup drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0233] Prescription: Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix isatidis 25g, Forsythia 10g, Honeysuckle 10g.

[0234] Preparation method: Take Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix Radix 25g, Forsythia 10g, Honeysuckle 10g, add 1190mL water to decoct twice, each time for 2 hours, combine the decoction, filter, the relative density of the filtrate concentration is 1.18-1.20 Add ethanol to the clear ointment until the alcohol content reaches 70%, stir well, let it stand for 24 hours, filter, and the filtrate is decompressed to recover ethanol and concentrate to obtain a concentrated medicinal solution; another sucrose is made into a simple syrup, and the above-mentioned concentrated For the medicinal solution, add 1000mL of water, stir well, filter, fill, and obtain.

[0235] Content determination:

[0236] Adopt high-performance liquid chromatography to carry out content determination to 7-methoxybaicalein:

[0237] (1) Chromatographic ...

Embodiment 2

[0250] Prescription: Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix isatidis 25g, Forsythia 10g, Honeysuckle 10g.

[0251] Preparation method: Take Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix Radix 25g, Forsythia 10g, Honeysuckle 10g, add 1190mL water to decoct twice, each time for 2 hours, combine the decoction, filter, the relative density of the filtrate concentration is 1.18-1.20 Add ethanol to the clear ointment until the alcohol content reaches 70%, stir well, let it stand for 24 hours, filter, and the filtrate is decompressed to recover ethanol and concentrate to obtain a concentrated medicinal solution; another sucrose is made into a simple syrup, and the above-mentioned concentrated For the medicinal solution, add 1000mL of water, stir well, filter, fill, and obtain.

[0252] Content determination:

[0253] Adopt high-performance liquid chromatography to carry out content determination to 7-methoxybaicalein:

[0254] (1) Chromatographic ...

Embodiment 3

[0267] Prescription: Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix isatidis 25g, Forsythia 10g, Honeysuckle 10g.

[0268] Preparation method: Take Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix Radix 25g, Forsythia 10g, Honeysuckle 10g, add 1190mL water to decoct twice, each time for 2 hours, combine the decoction, filter, the relative density of the filtrate concentration is 1.18-1.20 Add ethanol to the clear ointment until the alcohol content reaches 70%, stir well, let it stand for 24 hours, filter, and the filtrate is decompressed to recover ethanol and concentrate to obtain a concentrated medicinal solution; another sucrose is made into a simple syrup, and the above-mentioned concentrated For the medicinal solution, add 1000mL of water, stir well, filter, fill, and obtain.

[0269] Content determination:

[0270] Adopt high-performance liquid chromatography to carry out content determination to 7-methoxybaicalein:

[0271] (1) Chromatographic ...

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Abstract

The invention relates to the field of traditional Chinese medicines, particularly relates to compound herba houttuyniae syrup, and more particularly relates to a compound herba houttuyniae syrup medicine and pharmacy applications of the compound herba houttuyniae syrup medicine in treating nephritis as well as a detection method. The compound herba houttuyniae syrup medicine is prepared from the following medicinal materials in parts by weight: 100 parts of herba houttuyniae, 25 parts of radix scutellariae, 25 parts of radix isatidis, 10 parts of fructus forsythiae, and 10 parts of honeysuckle flowers. A preparation method of the compound herba houttuyniae syrup medicine comprises the following steps: taking herba houttuyniae, radix scutellariae, radix isatidis, fructus forsythiae and honeysuckle flowers, adding with 7-fold amount of water for decocting the medicinal materials for twice (each time of decocting lasts for 2h), mixing the decoctions, filtering the obtained mixed decoction, concentrating the filtrate to obtain clear paste with the relative density being 1.18-1.20, adding alcohol into the clear paste till the alcohol content is 70%, carrying out uniform stirring, carrying out standing for 24h, carrying out filtering, carrying out reduced-pressure alcohol recycling on the filtrate, and concentrating the filtrate with alcohol removed, thus obtaining concentrated liquid medicine; and taking saccharose, preparing simple syrup, adding with the concentrated liquid medicine, adding with water, carrying out uniform stirring, carrying out filtering, and carrying out filling, thus obtaining the compound herba houttuyniae syrup medicine. The compound herba houttuyniae syrup can be used for treating nephritis and mesangial proliferative glomerulonephritis. The invention further provides a method for detecting the quality of the compound herba houttuyniae syrup by adopting a high performance liquid chromatography and a gas chromatographic method.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to compound houttuynia cordata syrup medicine and its pharmaceutical application and detection method for treating nephritis. Background technique [0002] Mesangial proliferative glomerulonephritis (MsPGN) is a nephritis diagnosed according to the pathomorphology seen by light microscopy. Glomerular disease characterized by hyperglycemia. [0003] Mesangial proliferative glomerulonephritis is a nephritis diagnosed according to the pathomorphology seen by light microscopy. ball disease. In 1977, the World Health Organization officially listed it as a pathological type of primary glomerulonephritis. [0004] Mesangial proliferative nephritis can occur at any age, and the incidence rate is higher in older children and young adults, with a peak age of 16 to 30 years old. Male cases are slightly higher than females. Most mesangial proliferative glomerulonephritis has an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02A61K36/78A61P13/12
CPCA61K9/0095A61K36/195A61K36/315A61K36/355A61K36/539A61K36/634A61K36/78A61K2236/331A61K2236/39A61K2236/51A61K2236/53G01N30/02A61K2300/00
Inventor 张树乘赵伟郑秀娟耿宝星程淑云郭婷婷孙莉
Owner HEILONGJIANG ZHONGGUI PHARMA
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