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Application of alpha-ketoglutaric acid and alpha-ketoglutarate in preparation of feed additive capable of improving pig carcass composition

A pig feed additive, ketoglutarate technology, applied in the direction of application, animal feed, additional food elements, etc., can solve the problems of piglets easy to get sick, increase lean meat rate, low survival rate, etc., to increase pig eye muscle area, Improve lean meat percentage and increase the effect of eye muscle area

Inactive Publication Date: 2016-09-21
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the whole, the current research shows that α-KG mainly has a good effect on the improvement of the intestinal environment such as the small intestine of piglets and the digestive system, and is mainly used as a feed additive for weaned piglets, with the purpose of reducing the diarrhea rate of weaned piglets , enhance the resistance of weaned piglets, and promote the growth of weaned piglets, which has very positive significance for the problems of piglets that are prone to disease and low survival rate in the pig industry
[0004] However, there is still no good solution for how to maintain the existing production performance in the pig breeding industry, increase the lean meat rate and reduce fat deposition at the same time
However, the research on the composition of pig carcass by α-ketoglutarate (salt) is still blank, and there is no relevant technical report

Method used

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  • Application of alpha-ketoglutaric acid and alpha-ketoglutarate in preparation of feed additive capable of improving pig carcass composition
  • Application of alpha-ketoglutaric acid and alpha-ketoglutarate in preparation of feed additive capable of improving pig carcass composition
  • Application of alpha-ketoglutaric acid and alpha-ketoglutarate in preparation of feed additive capable of improving pig carcass composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 α - Effects of ketoglutaric acid on protein deposition in skeletal muscle cells

[0044] 1. In order to study the effect of α-ketoglutarate on protein deposition, skeletal muscle cells C2C12 were used as the research object, and skeletal muscle cells were seeded in a 6-well plate coated with polylysine. Two groups (control group and one treatment group) were treated with 2mM α-ketoglutarate for 48 h after being induced to differentiate into myotubes with 2% horse serum.

[0045] 2. Determination of the effect of α-ketoglutarate on MHCII of skeletal muscle cells

[0046] (1) The specific measurement method is:

[0047] After the cells were washed twice with PBS, fixed with 4% paraformaldehyde for 10 minutes, washed 3 times with PBS, 5 minutes each time, incubated with 0.4% Triton for 10 minutes, washed 3 times with PBS, blocked with 10% goat serum for 30 minutes at room temperature, Incubate the MyHC primary antibody overnight at 4°C, wash with PBS 3 ...

Embodiment 2

[0054] Example 2 α - Effects of ketoglutaric acid and its salts on growth performance, body composition, molecular mechanism of muscle hypertrophy and lipolysis in mice

[0055] 1. In order to study the effects of α-ketoglutarate and its salts on the growth performance, body composition, muscle hypertrophy and lipolysis of animals in vivo, the experiment took mice as the research objects, and selected 30 4-week-old male C57BL mice (13 ±1g) were divided into 3 groups after pre-feeding, single-cage feeding, one group was the blank control group, fed with water; the other two groups were the treatment group, fed with 1% and 2% α-ketoglutarate respectively Or alpha-ketoglutarate (Take alpha-ketoglutarate disodium salt as an example).

[0056] The mice in the two groups were fed with the same basal diet, and had free access to water and food and natural light during the feeding period. The body weight of the mice was recorded every week. After 9 weeks of the experiment, th...

Embodiment 3

[0071] Example 3 α - Effects of Ketoglutaric Acid and Its Salts on Carcass Composition of Finishing Pigs

[0072] 1. In order to study the effect of α-ketoglutaric acid and its salts on the carcass composition of pigs, 90 fattening pigs with a weight of about 80 kg were selected for the test and randomly divided into three groups, each with three pens. The test group added 0.5Kg / ton and 2Kg / ton α-ketoglutarate or α-ketoglutarate (taking α-ketoglutarate disodium salt as an example) to the basal diet respectively, and had free access to food and water. After 40 days of feeding, 10 pigs with a body weight close to the average were selected for slaughter to determine the carcass composition.

[0073] Specific indicators include:

[0074] (1) Average weight gain: Calculate the weight of each pig before the test and the live weight before slaughter, and then calculate the average weight gain and standard deviation of the test pigs in the implantation group and the control g...

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Abstract

The invention discloses an application of alpha-ketoglutaric acid and alpha-ketoglutarate taken as a feed additive capable of improving pig carcass composition or in preparation of the feed additive capable of improving the pig carcass composition. The improvement of the pig carcass composition refers to increase of a pork loin area, pig slaughtering rate and pig lean meat percentage and decrease of fat deposition, pig backfat thickness and / or pig abdominal fat weight. The study shows that by addition of alpha-ketoglutaric acid (or alpha-ketoglutarate) to pig feed, the pork loin area and the lean meat percentage can be remarkably increased, meanwhile, the fat deposition level is reduced, and the energy redistribution effect is realized. Besides, alpha-ketoglutaric acid (or alpha-ketoglutarate) does not have any adverse impact or toxic and side effects on pig growth performance and health, so that the pig feed capable of improving the pig carcass composition is prepared and the breeding benefit is increased on the premise that the growth is not limited in a pig raising process. Meanwhile, alpha-ketoglutaric acid (or alpha-ketoglutarate) and the additive thereof can be directly added to a premix compound and are convenient and fast to use, the preparation method is simple, requirements for special equipment are avoided, and good popularization and application prospect is realized.

Description

technical field [0001] The invention belongs to the technical field of feed additives. More specifically, it relates to the application of α-ketoglutarate and its salts in the preparation of feed additives for improving pig carcass composition. Background technique [0002] Muscle tissue and adipose tissue are the main components of the animal body, and they are also the main deposition sites of nutrients. Although after many years of genetic selection and breeding, the lean meat rate of the three-yuan miscellaneous commercial pig carcass has reached more than 60%, there are still 15-25% fat deposits. However, the lean meat rate of local breed pigs with excellent meat quality in my country is generally only 35% to 45%, and the fat rate is even as high as 40%. Therefore, how to increase the lean meat percentage of commercial pigs or local breed pigs, reduce fat deposition, improve carcass quality, improve feed utilization efficiency, and realize the so-called "nutrient redi...

Claims

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Application Information

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IPC IPC(8): A23K50/30A23K20/105A01K67/02
CPCA01K67/02
Inventor 束刚江青艳蔡兴才朱晓彤王丽娜
Owner SOUTH CHINA AGRI UNIV
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