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Absorbable wound buffering dressing

A kind of absorbent and wound technology, which is applied in application, medical science, surgery, etc., can solve the problems of inability to apply deep wounds and surgery, slow gelatin absorption speed, and increase the risk of wound infection, so as to facilitate dissolution and cell proliferation and differentiation, Effect of good healing environment, good biocompatibility

Inactive Publication Date: 2016-09-07
CHONGQING LIANBAI BOCHAO MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned wound dressing needs to be removed from the wound by removing the carrier after use. It cannot be applied to deep wounds and bleeding wounds that are difficult to reach during surgical operations, and the related materials cannot be degraded and absorbed in the body.
At present, the hemostatic materials used clinically mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials. These materials have achieved good results in animal experiments and clinical applications, but there are also some shortcomings: collagen The raw material is derived from animal tissue, which is a heterogeneous protein, which is prone to rejection and has potential allergies; gelatin absorbs slowly, usually for more than 4 weeks, which will increase the risk of wound infection; cellulose, the human body lacks enzymes to degrade it , the degradation time is long, which may bring side effects such as infection to the patient
[0006] At present, there are no relevant reports on wound dressings made of plant raw starch

Method used

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  • Absorbable wound buffering dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Absorbable Wound Buffer Dressing

[0050] The absorbable wound buffer dressing is formed by mixing plant cross-linked starch and body fluid, and the weight ratio of the plant cross-linked starch to body fluid is 10:100.

Embodiment 2

[0051] Example 2 Absorbable Wound Buffer Dressing

[0052] The absorbable wound buffer dressing is formed by mixing plant cross-linked starch and body fluid, and the weight ratio of the plant cross-linked starch to body fluid is 10:120.

Embodiment 3

[0053] The preparation method of embodiment 3 absorbable wound buffer dressing

[0054] Prepare absorbable wound buffer dressing according to the proportioning of embodiment 1, comprises the following steps:

[0055] 1) Dissolve 20 g of potato starch in 300 ml of distilled water, stir well, and adjust the pH to 9-10 with sodium hydroxide to obtain a starch suspension;

[0056] 2) Dissolve 4g of Span 80 in 50ml of liquid paraffin and stir for 20 minutes to obtain a mixed emulsified dispersant, then add starch suspension and stir for 20 minutes to obtain a starch emulsion;

[0057] 3) Dissolve 0.1 g of epichlorohydrin in distilled water, then add it into the starch emulsion, stir and cross-link for 5 hours, the stirring speed is 100 rpm, and the temperature is 40°C to obtain a cross-linking liquid;

[0058] 4) Leave the cross-linking liquid to stand for stratification, discard the supernatant, add 8 times the volume of ethyl acetate to the milky white liquid in the lower layer,...

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Abstract

The invention belongs to the field of biological medicine materials, and particularly relates to an absorbable wound buffering dressing. The absorbable wound buffering dressing is formed by mixing plant crosslinked starch and body fluid. A preparation method for the absorbable wound buffering dressing comprises the steps that raw plant starch is dissolved in a water medium, and after the pH value is adjusted, by means of emulsification cross-linking reaction, extraction washing, drying and sterilization, plant crosslinked starch particles are obtained; the plant crosslinked starch particles and the body fluid are mixed fully, and the absorbable wound buffering dressing is obtained. The absorbable wound buffering dressing can play a role in protecting the wound and buffering the external force, is beneficial for wound healing, good in biocompatibility and easy and convenient to use, can directly act on an ordinary bleeding wound, a deep bleeding wound and a bleeding wound of a part which is hard to arrive in an operation, carry out degradation and absorption in a body and does not need to be removed out of the wound. Using is easy and convenient, and the absorbable wound buffering dressing has great significance in development of new biological medicine materials.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to an absorbable wound buffer dressing. Background technique [0002] The types of dressings for wounds include powder dressings, foam dressings, porous body dressings or non-woven dressings, etc., and each dressing has its advantages and disadvantages. On the powder type dressing, its advantage is that the area of ​​action is large, so it can cover a wide range of wounds, but the disadvantage is that it is easy to form agglomerates and is difficult to remove. For foam dressings, the advantage is that it can adjust the wetness of the wound to avoid physical damage to the wound. The disadvantage is that it only acts on the surface of the wound, and its effect on cavity-type wounds is limited. The advantage of the porous body dressing is that it can absorb a large amount of body fluid, avoid wound inflammation and ulceration, and create a wet healing environment. The disadvantage ...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61L24/00A61L24/08
CPCA61L26/0023A61L24/0005A61L24/0031A61L24/0042A61L24/08A61L26/0057A61L26/008A61L26/009A61L2400/04C08L3/04
Inventor 彭洋张大
Owner CHONGQING LIANBAI BOCHAO MEDICAL EQUIP
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