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Yeast microcapsules of artichoke polyphenols and preparation method thereof

A technology of microcapsules and artichokes, applied in the field of medicine, can solve the problems of expensive equipment, residual chemical reagents, etc., and achieve the effects of convenient application, easy preservation and wide source.

Active Publication Date: 2019-08-30
XIAMEN TASMAN BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used microencapsulation methods are mostly physical and chemical methods such as complex coacervation method and spray drying method, but there are problems such as chemical reagent residue and expensive equipment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Take 2000 g of artichoke stems and leaves, pulverize them with a traditional Chinese medicine grinder, and pass through a 60-mesh sieve to obtain artichoke stems and leaves powder, add 40 times the amount of 95% ethanol, and extract 3 times with 800W ultrasonic waves, each time for 180 minutes; filter, combine the filtrates, Concentrate to obtain a clear paste with a relative density of 1.25 to 1.46 at 50°C, freeze-dry to obtain artichoke polyphenol freeze-dried powder;

[0025] 2) Take the commercially available Angel dry yeast, add 20 times the amount of 5% NaCl solution, shake in a water bath at 54°C for 5 hours, centrifuge at 5000rpm for 10 minutes, wash twice with water, and freeze-dry to complete the pretreatment of yeast cells;

[0026] 3) Mix the artichoke polyphenol freeze-dried powder obtained in step 1) with the pretreated yeast cells obtained in step 2) according to the ratio of core wall to 1:4, add 20 times the amount of distilled water, and at 70°C, Af...

Embodiment 2

[0029] 1) Take 1000 g of artichoke stems and leaves, pulverize them with a traditional Chinese medicine grinder, and pass through a 20-mesh sieve to obtain artichoke stems and leaves powder, add 40 times the amount of 95% ethanol, and extract 3 times with 400W ultrasonic waves, each time for 120 minutes; filter, combine the filtrates, Concentrate to obtain a clear paste with a relative density of 1.25 to 1.46 at 50°C, freeze-dry to obtain artichoke polyphenol freeze-dried powder;

[0030] 2) Take the commercially available Angel dry yeast, add 20 times the amount of 5% NaCl solution, shake in a water bath at 54°C for 5 hours, centrifuge at 5000rpm for 10 minutes, wash twice with water, and freeze-dry to complete the pretreatment of yeast cells;

[0031] 3) Mix the artichoke polyphenol freeze-dried powder obtained in step 1) with the pretreated yeast cells obtained in step 2) according to the ratio of core wall to 1:4, add 20 times the amount of distilled water, and at 60°C, Af...

Embodiment 3

[0033] 1) Take 1500 g of artichoke stems and leaves, pulverize them with a traditional Chinese medicine grinder, and pass through a 60-mesh sieve to obtain artichoke stems and leaves powder, add 40 times the amount of 95% ethanol, and extract 3 times with 800W ultrasonic waves, each time for 180min; filter, combine the filtrates, Concentrate to obtain a clear paste with a relative density of 1.25 to 1.46 at 50°C, freeze-dry to obtain artichoke polyphenol freeze-dried powder;

[0034] 2) Take the commercially available Angel dry yeast or the waste yeast recovered from the fermentation factory, add 20 times the amount of 5% NaCl solution, shake in a water bath at 54°C for 5 hours, centrifuge at 5000rpm for 10 minutes, wash twice with water, and freeze-dry to complete the pretreatment of yeast cells ;

[0035]3) Mix the artichoke polyphenol freeze-dried powder obtained in step 1) with the pretreated yeast cells obtained in step 2) according to the ratio of core wall to 1:1, add 2...

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Abstract

The invention discloses a yeast microcapsule of globe artichoke polyphenol and a preparation method of the yeast microcapsule. A yeast microcapsule product is prepared from freeze-dried powder of globe artichoke serving as a core material and yeast cells serving as an embedding wall material through water bath constant-temperature oscillation, centrifuging and freeze-drying, wherein the freeze-dried powder of globe artichoke is obtained through extraction, purification and freeze-drying. Yeast cells are rich in nutrition self, and due to microencapsulation of the yeast cells, the antioxidant activity of polyphenol is maintained, and furthermore nutrient substances of yeast are supplied, so that the yeast microcapsule has the characteristics of slow medicine release, high bioavailability, relatively simple preparation process and is suitable for industrial large-scale production, and meanwhile ideas and directions are provided for further application of polyphenol.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a yeast microcapsule of artichoke polyphenols and a preparation method thereof. Background technique [0002] Artichoke stems and leaves are rich in polyphenolic compounds, including caffeic acid, chlorogenic acid, rutinose, luteolin, etc. It can be used as the raw material of medicine and health products, and can also be used as medicine to prevent and treat insufficient bile secretion and hepatitis. In recent years, more research has focused on the prevention and treatment of chronic diseases such as anti-oxidation, lowering blood fat, and preventing hypertension. There are many polysaccharides in the crude polyphenol extract, but its biological activity is also very unstable, which limits its application. Using microcapsule technology can solve the above problems. [0003] Microcapsules use the wall material to embed the core material in a certain way. It is a kind of em...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K36/28A61P1/16
Inventor 汤须崇邓爱华蔡婀娜雷廷平寇馨月
Owner XIAMEN TASMAN BIO TECH
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