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Aperture and particle size monodisperse controllable mesoporous silicon rapid hemostatic powder and preparation method

A hemostatic powder, monodisperse technology, applied in medical formula, medical science, bandages, etc., can solve the problems of inability to achieve hemostatic performance, inability to determine the specific gravity of the hemostatic effect of mesoporous silicon materials, etc., and achieve good biocompatibility and tissue compatibility , Excellent hemostatic effect, no side effects

Active Publication Date: 2016-08-31
SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these mesoporous silicon also has certain hemostatic properties, due to the uncertainty of its pore size and particle size, mesoporous silicon materials cannot achieve the best hemostatic performance, and it is even more difficult in further multi-element and multi-component composite materials. Unable to determine the specific gravity of the hemostatic effect of mesoporous silicon materials

Method used

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  • Aperture and particle size monodisperse controllable mesoporous silicon rapid hemostatic powder and preparation method
  • Aperture and particle size monodisperse controllable mesoporous silicon rapid hemostatic powder and preparation method
  • Aperture and particle size monodisperse controllable mesoporous silicon rapid hemostatic powder and preparation method

Examples

Experimental program
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Embodiment 1

[0024] A method for preparing mesoporous silicon rapid hemostatic powder with monodisperse and controllable pore size and particle size, comprising the following steps:

[0025] 1) Add 300 mg of cetyltrimethylammonium bromide to 100 ml of water, and purging with high-purity nitrogen (99.99%) for 55 minutes while stirring;

[0026] 2) Add 9ml of n-octane, 5g of methyl methacrylate, 3ml of tetraethyl orthosilicate and azobisisobutylamidine hydrochloride to the liquid obtained in step 1) at 65°C under the stirring condition of 700rpm salt, the final concentration of the azobisisobutylamidine hydrochloride is 0.7 mg / ml, adjust the pH=9 with lysine, react for 6 hours, and then stand still for 16 hours to obtain a milky white suspension;

[0027] 3) Centrifuge the milky white suspension at 12,000 rpm for 20 minutes, and wash it with absolute ethanol for 5 times;

[0028] 4) In an air atmosphere, at a heating rate of 2°C / min, calcined at 600°C for 6 hours to remove the mesoporous te...

Embodiment 2

[0036] A method for preparing mesoporous silicon rapid hemostatic powder with monodisperse and controllable pore size and particle size, comprising the following steps:

[0037] 1) Add 350mg of cetyltrimethylammonium bromide to 100ml of water, and purging with high-purity nitrogen (99.99%) for 65min while stirring;

[0038] 2) Add 4ml of n-octane, 3g of methyl methacrylate, 3.5ml of tetraethyl orthosilicate and azobisisobutylamidine salt to the liquid obtained in step 1) at 70°C under the stirring condition of 800rpm acid salt, the final concentration of the azobisisobutylamidine hydrochloride is 0.8mg / ml, adjust the pH=10 with tris(hydroxymethyl)aminomethane, react for 4h, and then stand for 12h to obtain a milky white suspension;

[0039] 3) Centrifuge the milky white suspension at 16,000 rpm for 10 minutes, and wash it with absolute ethanol for 3 times;

[0040] 4) In an air atmosphere, at a heating rate of 2°C / min, calcined at 700°C for 4 hours to remove the mesoporous te...

Embodiment 3

[0042] A method for preparing mesoporous silicon rapid hemostatic powder with monodisperse and controllable pore size and particle size, comprising the following steps:

[0043] 1) Add 400 mg of cetyltrimethylammonium bromide to 100 ml of water, and purging with high-purity nitrogen (99.99%) for 60 minutes while stirring;

[0044] 2) Add 2ml of n-octane, 1g of methyl methacrylate, 4ml of tetraethyl orthosilicate and azobisisobutylamidine hydrochloride to the liquid obtained in step 1) at 75°C under the stirring condition of 900rpm salt, the final concentration of the azobisisobutylamidine hydrochloride is 0.9mg / ml, adjust the pH=9.5 with lysine, react for 5h, and then stand still for 14h to obtain a milky white suspension;

[0045] 3) Centrifuge the milky white suspension at 14,000 rpm for 15 minutes, and wash it 4 times with absolute ethanol;

[0046] 4) In an air atmosphere, at a heating rate of 2°C / min, calcined at 700°C for 5 hours to remove the mesoporous template, and o...

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Abstract

The invention discloses an aperture and particle size monodisperse controllable mesoporous silicon rapid hemostatic powder and a preparation method. The preparation method includes: 1) adding cetyl trimethylammonium bromide into water, and conducting nitrogen purging under stirring; 2) under stirring, adding n-octane, methyl methacrylate, tetraethyl orthosilicate and azobis(isobutylamidine hydrochloride) into the liquid obtained in step 1) in order, using lysine or tris(hydroxymethyl)aminomethane to adjust pH, carrying out reaction, and then performing standing to obtain a milky white suspension; 3) centrifuging the milky white suspension, and conducting centrifugal washing with anhydrous ethanol; and 4) in an air atmosphere, conducting calcination to remove a mesoporous template to obtain the white aperture and particle size monodisperse controllable mesoporous silicon rapid hemostatic powder. The hemostatic powder provided by the invention can stop bleeding rapidly, and is suitable for pre-hospital emergency treatment of serious bleeding patients, and has the characteristics of very fast hemostatic rate, hemostatic effect superior to chitosan and kaolin products, good biological and tissue compatibility, and no side effect.

Description

technical field [0001] The invention relates to a hemostatic material and a preparation method, in particular to a mesoporous silicon rapid hemostatic powder with monodisperse and controllable pore diameter and particle diameter. Background technique [0002] Traumatic hemorrhage is one of the most common injuries at the scene of various accidents in peacetime on the battlefield, and uncontrolled bleeding is the primary cause of on-site death and serious complications (such as amputation, etc.) of the wounded. Therefore, it is of great significance to effectively control the bleeding of the wounded at the scene and before the hospital. The tourniquet is a life-saving device that can control bleeding, but many parts of the human body, such as the chest, abdomen, head, neck, etc., cannot be used with a tourniquet. Traditional hemostatic materials (such as cotton gauze, bandages) are not ideal for the hemostatic effect of common wounds such as irregular shapes, deep, narrow, a...

Claims

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Application Information

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IPC IPC(8): A61L24/02A61L26/00A61L24/00
CPCA61L24/001A61L24/02A61L26/0004A61L26/0061A61L2400/04
Inventor 李钒田丰陈子浩刘长军武继民
Owner SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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