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Radix platycodonis composition for relieving coughs and eliminating phlegm and preparation method thereof

A composition, technology of bellflower extract, applied in the field of bellflower composition, can solve problems such as irritation and poor taste

Inactive Publication Date: 2016-08-31
CHANGSHU QIUSHI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In further research, it was found that the extract has a certain degree of irritation and poor taste when taken orally

Method used

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  • Radix platycodonis composition for relieving coughs and eliminating phlegm and preparation method thereof
  • Radix platycodonis composition for relieving coughs and eliminating phlegm and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: the preparation of sweet orange new side

[0015] (1) Preparation of bellflower extract

[0016] Refer to Zhang Lin et al.'s report "Using Weak Polarity Macroporous Resin to Prepare the Method and Application of Campanulaceae Total Saponins Extract" (Patent No. ZL2006100516078). Weigh 20 kg of Platycodon grandiflorum, extract twice with 10 times and 8 times of water successively, 1 hour each time, concentrate the extract, load the sample on AB-8 macroporous resin, wash with water to remove impurities, and then elute with 70% ethanol , collect the eluate, concentrate, and dry to obtain 288g of Platycodon grandiflorum extract.

[0017] Adopt HPLC-ELSD method to measure platycodon saponin D content in platycodonoid extract, chromatographic condition: Agilent Extend-C18 (5 μ m, 4.6 * 250mm); ELSD drift detection; Mobile phase acetonitrile (A)-water (B) gradient elution condition is 30%-70% A (15min); flow rate 1mL / min; column temperature 30°C; sample injecti...

experiment example 1

[0020] Experimental Example 1: Pharmacological Test of Ganju New Recipe

[0021] Refer to the experimental method of Liu Bin et al. "Evaluating the interaction between glycyrrhizin and platycodon saponin combined with improved contour method" (Chinese Journal of Experimental Formulas, 2007, 13(3), 40).

[0022] (1) cough test

[0023] The extract in Example 1 was used to conduct pharmacological experimental research in vivo. Take 70 SPF grade mice, male, after 3 days of adaptive feeding, they are randomly divided into seven groups: blank control group, Kebiqing group (20mg / kg), Platycodon grandiflorum group (40mg / kg), Ganjuxinfang (Grancifera + licorice, Fixed bellflower is 40mg / kg) group 1 (40+4mg / kg), 2 (40+12mg / kg), 3 (40+40mg / kg), 4 (40+80mg / kg); blank control group given the same dose distilled water (0.2ml / 10g), all medicines were given by intragastric administration, for 7 consecutive days, once every day at 9 o'clock in the morning. Sixty minutes after the last dose...

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Abstract

The invention discloses a radix platycodonis composition for relieving coughs and eliminating phlegm and a preparation method thereof. The preparation method comprises the following process steps that 10 parts by mass of radix platycodonis extract and 1-20 parts by mass of radix glycyrrhizae extract are selected, mixed to be uniform and prepared into a corresponding oral preparation, and the radix platycodonis composition is obtained, wherein the content of platycodin D in the radix platycodonis extract is not lower than 1.0%, and the content of glycyrrhizic acid in the radix glycyrrhizae extract is not lower than 20%. According to the radix platycodonis composition, traditional Chinese medicine with both pharmaceutical and food effects is preferred, a modern extraction technology is adopted for preparation, the formulation is screened and optimized through in-vivo pharmacological tests, it is proved that definite cough relieving and phlegm eliminating effects are achieved, and therefore the radix platycodonis composition can be applied to preparation of drugs and healthcare food with corresponding functions.

Description

technical field [0001] The invention relates to a platycodon grandiflorum composition for relieving cough and eliminating phlegm, and a preparation method of the platycodon grandiflorum composition, which belongs to the field of medicine and health food. technical background [0002] Platycodon grandiflorum (Platycodon grandiflorum) is a traditional Chinese medicine, which has various pharmacological activities such as expectorant, antitussive, hypoglycemic, anti-inflammatory, anti-ulcer, anti-tumor and antibacterial. It is a traditional medicinal material for both medicine and food. In clinical use, in order to further enhance its efficacy and reduce toxic and side effects, bellflower is often used in combination with licorice (Ganju Decoction, first seen in Zhang Zhongjing's "Treatise on Febrile Diseases"), which is the basic prescription for treating sore throat (Zhao Xiaoyan et al. Research on the correlation between compatibility and efficacy, Chinese Folk Therapy, 2014...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K36/346A61P11/14A61P11/10A23L33/00
CPCA61K36/484A23V2002/00A61K36/346A23V2200/314A23V2250/21A61K2300/00
Inventor 张琳李锡敏田景奎周生海刘江云
Owner CHANGSHU QIUSHI TECH CO LTD
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