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Preparation method of hydroxy propyl cellulose used for haemostasis

A technology of hydroxypropyl cellulose and gauze, which is applied in fiber treatment, plant fiber, blood diseases, etc., can solve the problems of low substitution degree and poor effect, achieve strong water absorption rate and water absorption rate, reduce blood flow speed, The effect of improving chemical reactivity

Inactive Publication Date: 2016-08-17
CHONGQING LIANBAI BOCHAO MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent (application number: 200710140180) adopts propylene oxide as etherifying agent to carry out etherification to slurry powder, has prepared the hydroxypropyl cellulose of low degree of substitution, and the hydroxypropyl cellulose prepared by this method is insoluble in water, can be used Poor effect on wound hemostasis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Alkalization treatment: Dissolve 10g of sodium hydroxide in distilled water to prepare a 10% sodium hydroxide solution, then completely immerse 20g of absorbent cotton gauze in the sodium hydroxide solution, and activate it for 1 hour to obtain alkali-activated gauze;

[0017] Etherification reaction: After drying the alkali-activated absorbent cotton gauze, take out 10g and add it to 500ml acetone solution, stir evenly, add 90ml chloropropanol to carry out etherification reaction, the reaction temperature is 55±5℃, react for 8h to obtain ether chemical reaction product;

[0018] Neutralization, washing and drying: Add acetic acid solution to the system after the etherification reaction until the pH value is 7.0, then wash with distilled water at 55±5°C, and then place the washed product in a constant temperature drying oven for drying treatment. That is, hydroxypropyl cellulose;

[0019] Ultrasonic treatment: immerse the hydroxypropyl cellulose obtained from the ether...

Embodiment 2

[0021] Alkalization treatment: Dissolve 10 g of sodium hydroxide in distilled water to prepare a 15% sodium hydroxide solution, then completely immerse 24 g of absorbent cotton gauze in the sodium hydroxide solution, and activate it for 3 hours to obtain alkali-activated gauze;

[0022] Etherification reaction: After drying the alkali-activated absorbent cotton gauze, take out 10g and add it to 500ml acetone solution, stir evenly, add 90ml chloropropanol to carry out etherification reaction, the reaction temperature is 55±5℃, react for 8h to obtain ether chemical reaction product;

[0023] Neutralization, washing and drying: Add acetic acid solution to the system after the etherification reaction until the pH value is 7.0, then wash with distilled water at 55±5°C, and then place the washed product in a constant temperature drying oven for drying treatment. That is, hydroxypropyl cellulose;

[0024] Ultrasonic treatment: immerse the hydroxypropyl cellulose obtained from the et...

Embodiment 3

[0026] Alkalization treatment: Dissolve 10 g of sodium hydroxide in distilled water to prepare a 15% sodium hydroxide solution, then completely immerse 24 g of absorbent cotton gauze in the sodium hydroxide solution, and activate it for 3 hours to obtain alkali-activated gauze;

[0027] Etherification reaction: After drying the alkali-activated absorbent cotton gauze, take out 10g and add it to 600ml of acetone solution, stir evenly, add 220ml of chloropropanol for etherification reaction, the reaction temperature is 65±5°C, and react for 4h to obtain ether chemical reaction product;

[0028] Neutralization, washing and drying: Add acetic acid solution to the system after the etherification reaction until the pH value is 7.5, then wash with distilled water at 55±5°C, and then place the washed product in a constant temperature drying oven for drying treatment. That is, hydroxypropyl cellulose;

[0029] Ultrasonic treatment: immerse the hydroxypropyl cellulose obtained from the...

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Abstract

The invention belongs to the field of biomedical materials, and concretely relates to a preparation method of hydroxy propyl cellulose used for haemostasis. The method takes natural absorbent cotton gauze or medical gauze as a raw material, and a reaction product is obtained through alkalization processing, etherification reaction, and ultrasonic treatment, and the hydroxy propyl cellulose used for haemostasis can be obtained through washing, drying, and disinfection. The hydroxy propyl cellulose belongs a neutral etherification product, which can overcome the defect that polar groups easily generate stimulation reaction, and the hydroxy propyl cellulose has high water-absorption swelling characteristic and rapid haemostasis. The material selects the natural cellulose as the raw material, which has the advantages of no toxicity, no stimulation, wide source, low cost, and simple process, and has wide clinical application prospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of hydroxypropyl cellulose for hemostasis. Background technique [0002] Bleeding is one of the problems that need to be solved urgently in surgery. Wound bleeding or bleeding during surgery often leads to unclear surgical field of vision, prolongs the operation time, affects the quality of the operation, increases the risk of the operation, and seriously causes serious complications, such as blood loss. Sexual shock can even endanger life and health. Traditional hemostasis methods such as compression, ligation, etc., are not very satisfactory in terms of clinical application. At present, the commonly used effective hemostasis method is to use biocompatible absorbable materials to stop bleeding. It is particularly important to provide a safe, effective, easy-to-use, and low-cost hemostatic material in hemostasis such as surgery and first aid. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M10/08D06M11/38D06M13/144A61P7/04D06M101/06
Inventor 张大刘琼林玲
Owner CHONGQING LIANBAI BOCHAO MEDICAL EQUIP
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