Method for preparing 3, 4-difluorobenzaldehyde
A technology of difluorobenzaldehyde and difluorobromobenzene, which is applied in the field of preparation of 3,4-difluorobenzaldehyde, can solve the problems of increased impurities, inconsistent thinking, and low product yield, and achieve the effect of improving the reaction yield
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[0017] 5L four-necked bottle, mechanical stirring, nitrogen protection, sequentially add magnesium strips, 400g tetrahydrofuran and iodine particles, then add 41.7g 2-chloropropane at room temperature, trigger after 10min, the maximum temperature is 40°C, drop the temperature at 30-40°C Add the prepared 2-chloropropane solution, drop it in 4.5 hours, keep it warm for 1 hour, and there is basically no magnesium strip. The temperature was lowered, and a solution of 3,4-difluorobromobenzene (654g of 3,4-difluorobromobenzene and 700g of tetrahydrofuran) was added dropwise at 0-10°C, and the addition was completed within 50 minutes. Insulation reaction, up to room temperature. After the reaction was completed, the temperature was lowered, and a DMF solution (291.3 g of DMF and 300 g of tetrahydrofuran) was added dropwise at 0-10° C. for 40 min. Control the temperature below 10°C, add 700g of water dropwise, then add concentrated hydrochloric acid dropwise to adjust the pH to about...
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