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Active polypeptide composition and application thereof to animal vaccine

A technology of active polypeptides and compositions, applied in the field of active polypeptide compositions and its application in animal vaccines, can solve the problems of inability to provide complete protection for animals and unsatisfactory vaccine immune effects, etc., to enhance animal immunity, improve The effect of the immune effect

Inactive Publication Date: 2016-08-17
崔长友
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vaccination is the most basic and effective way to prevent infectious diseases. However, due to various reasons, the immune effect of many vaccines is not very satisfactory and cannot provide complete protection for animals.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: To the immune enhancing effect of shelduck

[0027] 2-month-old shelducks were divided into three groups: an active polypeptide composition group, an active polypeptide group and a control group.

[0028] The active polypeptide composition group was injected with 50 nanograms of the composition, the active polypeptide group was injected with 50 nanograms of the active polypeptide alone, and the control group was injected with the same amount of sterile water. Three days later, the virus was challenged with Pasteurella anatipestifer, and the mortality rate of each group is shown in the table below.

[0029] group

Embodiment 2

[0030] Example 2: Immunoenhancing Effect on Broiler Chickens

[0031] 1-day-old Avian broiler chickens were divided into three groups: active polypeptide composition group, active polypeptide group and control group.

[0032] The active polypeptide composition group took 30 nanograms of the composition orally, the active polypeptide group took 30 nanograms of the active polypeptide alone, and the control group took the same amount of purified water orally. After 1 week of challenge with infectious bronchitis virus, the incidence rates of each group are shown in the table below.

[0033] group

Embodiment 3

[0034] Embodiment 3: improve the immune effect of vaccine to meat pigeon

[0035] The 1-month-old meat pigeons were divided into three groups: an active polypeptide composition group, an active polypeptide group and a control group.

[0036] The active polypeptide composition group was injected with 20 nanograms of the composition, the active polypeptide group was injected with 20 nanograms of the active polypeptide alone, and the control group was injected with the same amount of sterile water. Three days later, the chicken Newcastle disease virus LaSota strain vaccine was used for ocular immunization. Two weeks after immunization, they were challenged with the virulent Newcastle disease F48E8 strain, and the protection rates of each group are shown in the table below.

[0037] group

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PUM

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Abstract

The invention discloses an active polypeptide composition and application thereof to animal vaccines. The composition includes Lys-His-Gly-NH2 and Salpichrolide O, is dedicated to improve the immunity of animals such as chickens, ducks, rabbits, pigs, sheep, dogs, cows, and deer, and other economic animals, and can improve the immune effect of the vaccine. The active polypeptide is a small-molecular-weight natural substance in the body of animals, is non-toxic in individual usage or combination with vaccines, does not produce antibodies against the active polypeptide. The active polypeptide improves immunity by improving the host's own immune response capability and is very safe and reliable. The active polypeptide is convenient and low-cost for chemical synthesis manufacturing, and the pharmaceutical grade active polypeptide is more secure and reliable. Salpichrolide O is also a natural material with small molecular weight, and is non-toxic in individual usage or combination with vaccines; and the Salpichrolide O cooperating with the active polypeptide can further improve the host's own immune response capability, thereby further enhancing immunity.

Description

technical field [0001] The invention belongs to the field of animal vaccines, and specifically relates to an active polypeptide composition and its application in animal vaccines, which are specially used to improve the economic performance of animals such as chickens, ducks, rabbits, pigs, sheep, dogs, cattle and other livestock, poultry and various economic Animal immunity, and can improve the immune effect of vaccines. Background technique [0002] Adjuvants can be divided into two categories according to their mode of action. One is to act on the vaccine to improve the performance of the vaccine itself. For example, traditional chemical adjuvants such as aluminum hydroxide gel and oil can slow down the release rate of vaccine antigens in the body, but often Cause adverse reactions such as swelling at the injection site and even infection. Saponin glycosides can combine with certain antigenic proteins and cholesterol to form an immunostimulatory complex, so that non-gran...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/06A61K39/39A61P37/04A61K31/58
CPCA61K38/06A61K31/58A61K39/39A61K2039/55511A61K2039/55516
Inventor 崔长友
Owner 崔长友
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