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Preparation method of composition containing hyaluronic acid, obtained product and application

The technology of a hyaluronic acid and a composition is applied in the preparation of a composition containing hyaluronic acid, the obtained products and the application fields, and can solve the problems of reduced moisture retention, excellent biocompatibility, complicated preparation process, etc. Wide population, mild use, mild reaction conditions

Active Publication Date: 2016-08-17
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with hyaluronic acid, modified hyaluronic acid (that is, cationic hyaluronic acid) has improved affinity, but its excellent effects such as moisture retention and biocompatibility are reduced, and the reactions are all in stronger It is carried out in an alkaline environment (pH above 13), and the obtained product needs to be precipitated, separated, and purified with alcohol and other reagents before it can be used, and the preparation process is cumbersome

Method used

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  • Preparation method of composition containing hyaluronic acid, obtained product and application
  • Preparation method of composition containing hyaluronic acid, obtained product and application
  • Preparation method of composition containing hyaluronic acid, obtained product and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Accurately weigh 4.0kg of cationic cellulose powder (molecular weight 100000-2000000Da), 0.5kg of cosmetic grade low molecular weight sodium hyaluronate (molecular weight 200000~400000Da) and 0.5kg of cosmetic grade high molecular weight sodium hyaluronate (molecular weight 1600000~2000000Da), Pour the raw material powder into a 200L emulsification tank, add 12kg of propylene glycol, turn on the mechanical stirring and mix for 0.5h until the raw material is evenly dispersed in the propylene glycol; add 183L of water to the tank, and mechanically stir until the raw material is completely dissolved to form a uniform solution; Adjust the temperature to 60°C, adjust the pH to 5.5 with 20wt% citric acid solution, and keep it warm for 2 to 5 hours to obtain a light yellow viscous liquid with a certain viscosity. The measured dynamic viscosity is 10000mPa·s, and the viscous liquid is The composition containing hyaluronic acid can be directly packaged and used, and there is no d...

Embodiment 2

[0043] Accurately weigh 1.0kg of cationic guar gum powder (molecular weight 100000-2000000Da) and 5.0kg of cosmetic grade polymer sodium hyaluronate (molecular weight 1000000-1600000Da), pour the raw material powder into a 200L emulsification tank, add 12kg propylene glycol, and turn on the machine Stir and mix for 0.5h until the raw materials are evenly dispersed in propylene glycol; then add 183L of purified water to the tank, and mechanically stir until the raw materials are completely dissolved to form a uniform solution; adjust the temperature in the tank to 60°C, and adjust the pH Adjust it to 5.5, keep it warm for 2-5 hours, and obtain a white jelly with a certain viscosity. The measured dynamic viscosity is 250,000mPa·s. This viscous liquid is a composition containing hyaluronic acid. It can be directly packaged and used. No stratification was seen in the month.

Embodiment 3

[0045] Accurately weigh 3.0 kg of cationic guar gum powder (molecular weight 100,000-2,000,000 Da) and 3.0 kg of cosmetic-grade polymer sodium hyaluronate (molecular weight 1,600,000-2,000,000 Da), pour the raw material powder into a 200L emulsification tank, add 12 kg of propylene glycol, and turn on the machine Stir and mix for 1 hour until the raw materials are evenly dispersed in propylene glycol; add 183L of water to the tank, and mechanically stir until the raw materials are completely dissolved to form a uniform solution; adjust the temperature in the tank to 60°C, and adjust the pH to 5.5 with 20wt% citric acid solution , Insulated for 2 to 5 hours, a white jelly with a certain viscosity was obtained, and the measured dynamic viscosity was 380000mPa·s. The viscous liquid is the hyaluronic acid-containing composition, which can be directly packaged and used, and there is no delamination after being placed for 3 months.

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Abstract

The invention discloses a preparation method of a composition containing hyaluronic acid, an obtained product and application. At least one cationic polymer and at least one molecular hyaluronic acid or salt of hyaluronic acid are mixed and subjected to complexing reaction, reaction is stopped when the system dynamic viscosity is 100-400000 mPa.s, and a mixture obtained through reaction is the composition containing hyaluronic acid. Operation is easy, reaction conditions are mild, the complexing product can be directly used as the composition without alcohol precipitation, separation, purification, washing and other treatment operation, and the product is easier and more convenient and rapid to use. The product has high affinity on viable tissue, can be more easily adsorbed to skin (including scalp) or hair, has functions of moisturizing, nursing and conditioning, can make skin and hair moist and smooth, can be used in daily use chemical articles with skin moisturizing and nursing or hair washing and caring effects and has quite good application prospects.

Description

technical field [0001] The present invention relates to a preparation method of a composition containing hyaluronic acid, and also relates to the composition obtained according to the method and the application of the composition. The composition has high affinity and has great potential in the daily chemical field good application. Background technique [0002] Hyaluronic acid is a mucopolysaccharide widely present in living organisms, and is widely used in cosmetics due to its high moisturizing effect. However, since the surface of hair and skin is usually negatively charged, hyaluronic acid is also usually negatively charged due to its anionic functional groups such as carboxyl groups. Therefore, when hyaluronic acid is used to treat hair or skin, the two repel each other. For this reason, hyaluronic acid is generally difficult to adsorb on the surface of hair and skin. [0003] Cationic polymers are an important class of functional compounds, which are positively charg...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/34A61K8/81A61Q5/02A61Q5/12A61Q19/00
CPCA61K8/345A61K8/731A61K8/735A61K8/737A61K8/817A61K2800/5426A61Q5/02A61Q5/12A61Q19/00
Inventor 冯宁申凤同耿凤石艳丽郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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