Medicine for treating hypertension and preparation method thereof

Abstract

The invention relates to the technical field of a medicine preparation, and concretely discloses medicine for treating hypertension and a preparation method thereof. The medicine has the active ingredients of nifedipine and metoprolol, wherein the mass ratio of the nifedipine to the metoprolol is 2:1. The metoprolol can decelerate the heart rate and has the hypotensive effect; the nifedipine can accelerate the heart rate and has the hypotensive effect; the metoprolol and the nifedipine realize the mutual complementation, so that the hypotensive effect is enhanced; the contraindication, the intolerance and the side effects generated in the single medication process are reduced. Compared with the step treatment and sequential treatment of the single-ingredient medication, the composite medicine has the advantages that the taking and the treatment are simple, convenient and fast. Meanwhile, the medicine is applicable to about 90 percent of hypotensive people groups, and is particularly suitable for hyperdynamic and high-impedance hypertension; the myocardial ischemia due to hypertension can be obviously relieved; meanwhile, the atrioventricular hypertrophy and various conduction blocking can be delayed or blocked.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a medicine for treating hypertension and a preparation method thereof. Background technique [0002] At present, there are more than 100 million hypertensive patients in my country, most of which have unknown causes and are a lifelong disease. Long-term and effective implementation of antihypertensive drug therapy is one of the main ways to improve the quality of life and survival rate of hypertensive patients. It has become a consensus in the academic community that hypertensive patients need to use antihypertensive drugs for life. The good control of blood pressure mainly depends on the effect of drugs, adverse drug reactions, patient compliance and treatment costs. At present, several types of drugs commonly used in clinical treatment of hypertension are mainly diuretics, heatstroke α-receptor stimulants and peripheral α-receptor blockers, β-receptor block...

AI Technical Summary

Problems solved by technology

This single drug can generally only control the blood pressure of 40% to 60% or even less patients, and the dose-effect curve of commonly used drugs is low and flat, and the effect is not good. When the dose is increased, the curative effect does not increase much, and the side effects can increase logarithmically. After antihypertensive drugs, the body's compensatory mechanism can produce counter-regulation, which can reduce or offset the antihypertensive effect

[0003] In view of the shortcomings of single preparations in the treatment of hypertension, although clinicians can prescribe a combination of two or more different medicines according to the treatment needs of patients, the following treatment defects still exist: (1) the above-mentioned medicines for the treatment of hypertension A considerable part of the drugs have a large liver first-pass effect, and oral administration requires a large dose to reach the effective blood concentration, which increases the cost of treatment, but the treatment efficiency is low; (2) drug absorption is greatly affected by gastrointestinal factors, drug absorption There are large individual differences in metabolism and in vivo efficacy, and the curative effect is uncertain and uncontrollable; (3) frequent administration is required, and the treatment of hypertension is a long-term behavior, which usually requires life-long medication, and the patient's treatment remains unchanged and the compliance is low; (4) based on unilateral Due to the low and flat dose-effect curve of the drug, the effective therapeutic effect is usually achieved by increasing the dose of the drug, but this usually causes relatively large toxic and side effects and increases the incidence of adverse reactions

(5) It is inconvenient to use combined medication

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