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Uniform-grain-size agarose gel microsphere production system and production process thereof

A technology of agarose gel microspheres and agarose gel, which is applied in the field of agarose gel microsphere production system, can solve the problems of different particle sizes, wide distribution coefficients, poor microsphere formation rate, etc., and achieve The effect of intelligent continuous production, realizing recycling and saving labor costs

Active Publication Date: 2016-07-20
厦门三冀科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The preparation method of agarose gel microspheres is mainly the traditional preparation method of agarose gel microspheres, which is mainly the emulsification method. There are many defects in this method. The distribution coefficient is wide, and it needs to be separated by a cumbersome and time-consuming follow-up screening process, resulting in low product yield and poor preparation repeatability. However, some of the more advanced production processes currently have defects such as easy pollution and long process time, which cannot meet the requirements. The development of my country's biomedical industry has a large demand for agarose gel microspheres

Method used

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  • Uniform-grain-size agarose gel microsphere production system and production process thereof
  • Uniform-grain-size agarose gel microsphere production system and production process thereof
  • Uniform-grain-size agarose gel microsphere production system and production process thereof

Examples

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Embodiment 1

[0028] Example 1: Such as Figure 1~4 Shown, a kind of agarose gel microsphere production system with uniform particle diameter comprises production area 100 and the control area 200 that is positioned at the side of production area, rubber mill and premix heating still are arranged in described production area 100, The premix heating kettle is a premix kettle with heating function, the rubber mill is connected with a microwave heating kettle 110, the premix heating kettle is connected with an ultrasonic uniform defoaming kettle 120, and the microwave The heating kettle 110 and the ultrasonic uniform defoaming kettle 120 are all connected with an ultrasonic homogenizing kettle 130, the high-frequency ultrasonic homogenizing kettle is connected with an oil-water separator, and the water phase outlet of the oil-water separator is connected with a microsphere The cleaner is connected, and the microsphere cleaner is connected with a mixer, and the mixer is connected with a meter...

Embodiment 2

[0042] Example 2: A high-efficiency production process of agarose gel microspheres with uniform particle size, comprising the production system of agarose gel microspheres with uniform particle size as described in Example 1, and carried out according to the following steps: (1) agarose is pressed A certain ratio is added to ultrapure water, and transported to a rubber mill for 10 minutes, and then transported to a microwave heating kettle to quickly and fully dissolve to form glue A; at the same time, light oil as a solvent and heavy oil as a surfactant Add it into the pre-mixed heating tank at a certain ratio, mix and heat it, and then transport it to the ultrasonic uniform defoaming tank for treatment to form a uniform non-foaming thermal oil phase B; (2) Transport the uniform non-foaming thermal oil phase B to the ultrasonic homogenizing tank Heat to 200°C, turn on the high-frequency ultrasonic generator and start the side stirring paddle and the emulsification head, the ...

Embodiment 3

[0048] Example 3: A high-efficiency production process of agarose gel microspheres with uniform particle size, comprising the production system of agarose gel microspheres with uniform particle size as described in Example 1, and carried out according to the following steps: (1) agarose is pressed A certain ratio is added to ultrapure water, and transported to a rubber mill for 20 minutes, and then transported to a microwave heating kettle to quickly and fully dissolve to form glue A; at the same time, light oil as a solvent and heavy oil as a surfactant Add it into the pre-mixed heating tank at a certain ratio, mix and heat it, and then transport it to the ultrasonic uniform defoaming tank for treatment to form a uniform non-foaming thermal oil phase B; (2) Transport the uniform non-foaming thermal oil phase B to the ultrasonic homogenizing tank Heat to 300°C, turn on the high-frequency ultrasonic generator and start the side stirring paddle and the emulsification head, the ...

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Abstract

The invention relates to a uniform-grain-size agarose gel microsphere production system and a production process thereof. The system comprises a production area and a control area positioned beside the production area, a gel mill and a premix heating kettle are arranged in the production area, the gel mill is connected with a microwave heating kettle, the premix heating kettle is connected with an ultrasonic uniform defoaming kettle, both the microwave heating kettle and the ultrasonic uniform defoaming kettle are connected with an ultrasonic homogenizing kettle, a high-frequency ultrasonic homogenizing kettle is connected with an oil-water separator, a water-phase outlet of the oil-gas separator is connected with a microsphere cleaning device which is connected with a mixer, and the mixer is connected with a metering subpackaging machine. Large-scale production of agarose gel microspheres uniform in grain size, smooth in sphere form and free of impurities is realized, and the system plays a certain role in promoting development of biomedicine industry of China and has good social and economic benefit.

Description

technical field [0001] The invention relates to a production system of agarose gel microspheres with uniform particle size and a production process thereof, belonging to the field of biopharmaceutical materials. Background technique [0002] In the national "Twelfth Five-Year Plan", efforts are made to promote economic restructuring and the development of strategic emerging industries. One of the country's key development directions is to focus on improving biomedical research and development capabilities, develop new pharmaceutical products, and accelerate the development of biomedical engineering technologies and products. Promote the large-scale development of biological manufacturing, accelerate the construction of a modern biological industry system with an international advanced level, and accelerate the research and development and industrialization of marine biotechnology and products. Agarose is a natural marine polysaccharide isolated from large marine algae such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/12
CPCC08B37/0003C08B37/0039
Inventor 郭东旭黎泉香兰旺仁稽海峰
Owner 厦门三冀科技有限公司
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