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Pharmaceutical composition of famciclovir and pharmaceutical application of pharmaceutical composition

A technology of famciclovir and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems that have not been reported related to famciclovir epilepsy, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-07-20
周俭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between famciclovir and its pharmaceutical composition and epilepsy

Method used

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  • Pharmaceutical composition of famciclovir and pharmaceutical application of pharmaceutical composition
  • Pharmaceutical composition of famciclovir and pharmaceutical application of pharmaceutical composition
  • Pharmaceutical composition of famciclovir and pharmaceutical application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Separation method: (a) Crush Changshan (2kg), extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and successively use petroleum ether (3L×3 times) , ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) Use D101 type macroporous resin to remove impurities from the ethyl acetate extract, first elute with 25% ethanol for 8 column volumes, then use 70% ethanol for 12 column volumes, collect 70% eluate, and concentrate under reduced pressure to obtain 70% ethanol elution concentrate; (c) 70% ethanol elution concentrate in step (b) is separated with normal phase silica gel, and the volume ratio is 85:1 (10 column volumes), 45:1 (8 column volumes) successively column volume), 25:1 (10 colu...

Embodiment 2

[0024] Embodiment 2: pharmacological action

[0025] In this example, rats were intraperitoneally injected with 6 million U / kg of penicillin to make an epilepsy model, and to observe the effect of drugs on epilepsy.

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] 90 Wistar rats, half male and half male, weighing 120±20 g, were provided by the Experimental Animal Center of Heilongjiang University of Traditional Chinese Medicine.

[0029] 1.2 Reagents and samples

[0030] Famciclovir was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Phenytoin: produced by Tianjin Lisheng Pharmaceutical General Factory; penicillin: produced by Harbin Pharmaceutical General Factory; urethane: produced by Harbin Pharmaceutical General Factory.

[0031] 1.3 Instruments

[0032] LMB-2B two-channel physiological recorder: produced by Chengdu Instrument...

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PUM

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Abstract

The invention discloses a pharmaceutical composition of famciclovir and pharmaceutical application of the pharmaceutical composition. The pharmaceutical composition comprises the famciclovir and a natural product compound (I) of a novel structure; when in single action, the famciclovir and the compound (I) have therapeutic effect in epilepsy; when the famciclovir and the compound (I) are in combined action, the therapeutic effect in epilepsy is further improved; the pharmaceutical composition can be developed into drugs for treating epilepsy; the pharmaceutical composition has outstanding substantive features and significant improvement as compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of famciclovir, in particular to a pharmaceutical composition of famciclovir and its medical application. Background technique [0002] After famciclovir enters the human body, it is rapidly transformed into penciclovir. Penciclovir can be phosphorylated by the thymidine kinase encoded by the virus into OCV monophosphate, and then phosphorylated by the host to become penciclovir triphosphate. Virus-infected cells are rapidly formed, slowly metabolized, and the half-life is prolonged. It participates in the competition of HBV DNA-p guanosine triphosphate (Pgtp), and enters DNA, acts on the initiation and elongation steps of DNA synthesis, and inhibits DNA synthesis. Varicella-zoster virus, herpes simplex virus types 1 and 2, and HBV all have strong inhibitory effects. [0003] So far, there has been no report on the correlation between famciclovir and its pharmaceutical ...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K31/56A61K31/52A61P25/08
CPCC07J63/008A61K31/52A61K31/56
Inventor 周俭
Owner 周俭
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