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Invermectin and fenbendazole suspension injection and preparing method thereof

A technology for suspending injection and ivermectin, which is applied in the directions of liquid delivery, pharmaceutical formulation, emulsion delivery, etc., to achieve the effects of being beneficial to absorption, reducing drug costs, and expanding anti-insect spectrum.

Active Publication Date: 2016-06-29
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report about the suspension injection prepared by directly dispersing the two drugs of ivermectin and fenbendazole in water

Method used

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  • Invermectin and fenbendazole suspension injection and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] An ivermectin fenbendazole suspension injection, its formula is respectively by weight component drug ivermectin 0.2g, fenbendazole 2.5g, wetting agent (Tween-20) 0.2g, Suspending agent sodium carboxymethylcellulose 0.3g, pH regulator sorbic acid 0.002g, deflocculant sodium citrate 1.0g, preservative phenylethyl alcohol 0.1g.

[0029] The preparation method of described ivermectin fenbendazole suspension injection comprises the steps:

[0030] S1. According to the weight ratio of the above prescription, weigh 0.2g Tween-20, add appropriate amount of water for injection to dissolve, set aside.

[0031] S2. According to the weight ratio of the above prescription, weigh 0.3g sodium carboxymethylcellulose, 1.0g sodium citrate, 0.1g phenylethyl alcohol, and 0.002g sorbic acid, add appropriate amount of purified water to dissolve, and set aside.

[0032] S3. According to the weight ratio of the above prescription, weigh 0.2g of ivermectin and 2.5g of fenbendazole, add them i...

Embodiment 2

[0035] A kind of ivermectin fenbendazole suspension injection, its formula is respectively by weight component drug ivermectin 0.24g, fenbendazole 3g, wetting agent (Tween-60) 0.2g, auxiliary Suspending agent carboxymethylcellulose sodium 0.3g, deflocculant sodium citrate 1.2g, pH regulator benzoic acid 0.003g, preservative sodium benzoate 0.2g.

[0036] S1. According to the weight ratio of the above prescription, weigh 0.2g Tween-60, add appropriate amount of water for injection to dissolve, set aside.

[0037] S2. According to the weight ratio of the above prescription, weigh 0.3g sodium carboxymethylcellulose, 0.2g sodium benzoate, 1.2g sodium citrate, and 0.003g benzoic acid, add appropriate amount of purified water to dissolve, set aside.

[0038] S3. According to the weight ratio of the above prescription, weigh 0.24g of ivermectin and 3g of fenbendazole, add them into the solution obtained in S1, and stir evenly.

[0039] S4. Add the solution obtained in S2 to the solu...

Embodiment 3

[0041] An ivermectin fenbendazole suspension injection, the formula of which is 0.32g of component drug ivermectin, 4g of fenbendazole and 0.2g of wetting agent (polyethylene glycol-400) by weight , suspending agent sodium carboxymethyl cellulose 0.4g, deflocculant sodium citrate 1.5g, pH regulator benzoic acid 0.003g, preservative phenol 0.2g.

[0042] S1. According to the weight ratio of the above prescription, weigh 0.2g of polyethylene glycol-400, add an appropriate amount of water for injection to dissolve, and set aside.

[0043] S2. According to the weight ratio of the above prescription, weigh 0.4g sodium carboxymethyl cellulose, 0.2g phenol, 1.4g sodium citrate, and 0.003g benzoic acid, add appropriate amount of purified water to dissolve, set aside.

[0044] S3. According to the weight ratio of the above prescription, weigh 0.32g of ivermectin and 4g of fenbendazole, add them into the solution obtained in S1, and stir evenly.

[0045] S4. Add the solution obtained in ...

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Abstract

The invention discloses an invermectin and fenbendazole suspension injection and a preparing method thereof. Each 100 ml of the invermectin and fenbendazole suspension injection is prepared from, by mass, 2.5-5 g of fenbendazole, 0.2-0.4 g of invermectin, 0.2-1 g of a wetting agent, 0.8-1.8 g of a suspending agent, 0.1-0.4 g of a preservative, 1.0-2.0 g of a deflocculant and 0.002-0.008 g of a pH regulator. The preparing method of the suspension injection comprises the following steps that firstly, the wetting agent is added with water to be dissolved; secondly, the suspending agent, the preservative, the deflocculant and the pH regulator are added with water to be dissolved respectively; thirdly, invermectin and fenbendazole are added in the solution obtained in the first step and evenly mixed; fourthly, the solution obtained in the second step is added into the solution obtained in the third step under a shearing condition, and shearing is carried out. The preparing method of the invermectin and fenbendazole suspension injection is easy to implement, and a small dose of organic solvents are used; in addition, the insect resistant spectrum is enlarged through joint use of invermectin and fenbendazole, and the cost and toxicity of pesticide are greatly reduced.

Description

technical field [0001] The invention relates to the technical field of preparation of animal medicines, in particular to a medicine for treating internal and external parasites of livestock, more specifically to an ivermectin fenbendazole suspension injection and a preparation method thereof. Background technique [0002] Parasitic diseases are an important part of livestock infectious diseases, and there are many kinds of pathogenic parasites. Common internal parasites include roundworms, flagellates, strongyloides, trichinella spiralis, nodularia, coccidia, tapeworms, trematodes, etc. In vitro Parasites include ticks, fleas, flies, ticks, lice, etc. It seriously affects the output of meat, milk and eggs, and the quality of fur. Some zoonotic parasitic diseases also directly endanger human health, causing huge economic losses to the animal husbandry industry and causing serious public health problems. With the long-term use of antiparasitic drugs, drug resistance of parasi...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/10A61P33/00A61K31/4184
CPCA61K47/38A61K9/0019A61K9/10A61K31/4184A61K31/7048A61K2300/00
Inventor 黄显会郜进魏开赟张少南
Owner SOUTH CHINA AGRI UNIV
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