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Decoquinate dry suspension and preparation method thereof

A technology of decoquinate and dry suspension, which is applied in the direction of anti-infective drugs, active ingredients of heterocyclic compounds, powder delivery, etc., and can solve the problems that the decoquinate preparation cannot be administered through drinking water and that the decoquinate preparation is insoluble in water, etc. Achieve the effects of good drug content uniformity, simple preparation method, and high sedimentation volume ratio

Inactive Publication Date: 2016-06-29
陈小媚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that the decoquinate preparation is insoluble in water, the invention provides a kind of decoquinate dry suspension, which solves the technical problem that the decoquinate preparation is insoluble in water and cannot be administered through drinking water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: decoquinate dry suspension and preparation method thereof

[0014] 1. Prescription: Decoxyquinate 2g, sodium carboxymethylcellulose 1g, polyvinylpyrrolidone 5ml, starch-lactose complex to the full amount.

[0015] 2. Preparation method: take the decoquinate of the prescription amount, add the solvent of the prescription quantity, stir, make the decoquinate dissolve completely, and obtain a clear solution; add suspending agent and auxiliary materials successively in the solution, stir, and mix well , sieved, dried, and sieved again.

Embodiment 2

[0016] Embodiment 2: decoquinate dry suspension and preparation method thereof

[0017] 1. Prescription: decoxyquinate 10g, gum arabic powder 10g, dimethylformamide 20ml, lactose to the full amount.

[0018] 2. Preparation method: take the decoquinate of the prescription amount, add the solvent of the prescription quantity, stir, make the decoquinate dissolve completely, and obtain a clear solution; add suspending agent and auxiliary materials successively in the solution, stir, and mix well , sieved, dried, and sieved again.

Embodiment 3

[0019] Embodiment 3: decoquinate dry suspension and preparation method thereof

[0020] 1. Prescription: 6g of decoquinate, a mixture of sodium alginate and microcrystalline cellulose (sodium alginate:microcrystalline cellulose=2:8) 8g, a mixture of ethanol and glycerin (ethanol:glycerol=7:3) 15ml, mannitol to make up to the full amount.

[0021] 2. Preparation method: take the decoquinate of the prescription amount, add the solvent of the prescription quantity, stir, make the decoquinate dissolve completely, and obtain a clear solution; add suspending agent and auxiliary materials successively in the solution, stir, and mix well , sieved, dried, and sieved again.

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PUM

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Abstract

The invention discloses a decoquinate dry suspension and a preparation method thereof, and belongs to the field of a veterinary preparation. The decoquinate dry suspension is prepared from a suspending aid, a solvent and an auxiliary material. The decoquinate dry suspension and the preparation method have the characteristics that the preparation method is simple; the settling volume ratio is high; the medicine content uniformity is good, and the like. The decoquinate dry suspension can be easily accepted by patients.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a decoquinate dry suspension and a preparation method thereof. Background technique [0002] Decoxyquinate is a new type of high-efficiency livestock and poultry special anticoccidial drug, and clinical data show that decoquinate has no great impact on the growth performance of livestock such as chickens, pigs, cattle and sheep, and is mainly used for cattle and goats , Sheep, chicken, pig coccidiosis control. It is the only chemical anticoccidial drug approved for use in the world, and it has no incompatibility with the veterinary drug feed additives currently allowed in China. [0003] Decoxyquinate is white or off-white crystalline powder, slightly soluble in ethanol, insoluble in water, and its preparation cannot be used after being dissolved in water, which affects its absorption and convenience after use, and brings restrictions to its application. ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/47A61P33/02
CPCA61K9/146A61K31/47
Inventor 陈小媚
Owner 陈小媚
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