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An electrospun film-coated composite pelvic floor patch and preparation method thereof

An electrospinning and patch technology, used in medical science, incontinence prevention devices, prostheses, etc., can solve the problems of excessive adhesion at the repair site, insufficient flexibility, and hard polypropylene feel, achieve high porosity, and avoid tissue damage. Effect

Inactive Publication Date: 2019-01-11
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide an electrospun film-coated composite pelvic floor patch and its preparation method. The present invention uses non-degradable polypropylene with a large aperture as the skeleton and a composite patch covered with a degradable material. The good integrity and softness of the patch are maintained in the body, and the degradable material degrades after being implanted in the body for a certain period of time, but the patch still has a certain supporting force; Insufficient softness and excessive adhesion of repaired parts

Method used

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  • An electrospun film-coated composite pelvic floor patch and preparation method thereof
  • An electrospun film-coated composite pelvic floor patch and preparation method thereof
  • An electrospun film-coated composite pelvic floor patch and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] 1. Preparation of Polypropylene Rhomboid Mesh Patch

[0034] (1) Patch weaving: Use polypropylene monofilament with a diameter of 0.1mm as the raw material, and weave it on a three-bar Raschel warp knitting machine with a machine number of 20E to make a patch with a rhombic mesh structure. The yarn motion numbers are:

[0035] GB1:1-0 / 0-1 / / full wear

[0036] GB2:0-0 / 2-2 / 1-1 / 3-3 / 0-0 / 3-3 / 1-1 / 2-2 / 0-0 / 3-3 / / one wear one empty

[0037] GB3:3-3 / 1-1 / 2-2 / 0-0 / 3-3 / 0-0 / 2-2 / 1-1 / 3-3 / 0-0 / / one wear one empty

[0038] (2) Washing of patches: Gently rinse in cold water to remove surface impurities, and dry naturally at room temperature.

[0039] (3) Heat setting of the patch: the heat setting temperature is 130°C, and the heat setting time is 15 minutes.

[0040] 2. Configuration of electrospinning solution

[0041] Weigh 0.84g of polylactic acid granules and 0.36g of polycaprolactone granules into a screw-top glass bottle with a sealed cover, mix the DMC and DMF solutions evenly a...

Embodiment 2

[0052] 1. Preparation of polypropylene hexagonal mesh patch

[0053] (1) Patch weaving: use polypropylene monofilament with a diameter of 0.1mm as the raw material, and weave it on a three-bar Raschel warp knitting machine with a machine number of 16E to make a patch with a hexagonal mesh structure. The yarn motion numbers are:

[0054] GB1: 2-3 / 2-1 / 2-3 / 1-0 / 1-2 / 1-0 / / 1 wear 1 empty

[0055] GB2: 1-1 / 1-0 / 1-0 / 2-2 / 2-3 / 2-3 / / 1 empty 1 wear

[0056] GB3: 1-0 / 1-2 / 1-0 / 2-3 / 2-1 / 2-3 / / 1 wear 1 empty

[0057] (2) Washing of patches: Gently rinse in cold water to remove surface impurities, and dry naturally at room temperature.

[0058] (3) Heat setting of the patch: the heat setting temperature is 130°C, and the heat setting time is 10 minutes.

[0059] 2. Configuration of electrospinning solution

[0060] Weigh 0.84g of polylactic acid granules and 0.36g of polycaprolactone granules into a screw-top glass bottle with a sealed cover, mix the DMC and DMF solutions evenly at a mass ra...

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Abstract

The invention relates to an electrostatic-spun coated composite pelvic mesh and a manufacturing method thereof. The composite pelvic mesh is composed of a coating layer and a supporting layer, wherein the coating layer is bonded on one side of the supporting layer. The manufacturing method comprises the following steps: mixing polylactic acid and polycaprolactone, dissolving the mixed polylactic acid and polycaprolactone in a solvent, and then heating and stirring, so that a polylactic acid / polycaprolactone solution is obtained; brushing a layer of binding agent on one surface of a polypropylene warp-knitted mesh and sticking the other surface on an aluminum foil which serves as an electrostatic spinning receiving device, and conducting electrostatic spinning by using the polylactic acid / polycaprolactone solution as a spinning solution; and volatilizing and disinfecting, so that the pelvic mesh is obtained. The pelvic mesh disclosed by the invention, by combining absorbable materials and non-absorbable materials and on the basis of characteristics of the electrostatic spinning which is high in specific surface area and high in porosity, has the features of being light in weight, high in porosity, soft to touch, good in biocompatibility and the like.

Description

technical field [0001] The invention belongs to the field of pelvic bottom patch and its preparation, in particular to an electrospun film-coated composite pelvic bottom patch and a preparation method thereof. Background technique [0002] Female pelvic floor dysfunction (PFD) is characterized by stress urinary incontinence (stress urinary incontinence, SUI), pelvic organ prolapse (pelvic organ prolapse, POP) and chronic pelvic pain (chronic pelvic pain, CPP) Etc. is a kind of gynecological disease of main symptom. A large number of studies have shown that pelvic floor mesh is an important pelvic floor tissue replacement, which can replace the weak and damaged pelvic floor fascia tissue. Compared with traditional hysterectomy, mesh has been gradually proven to improve the safety of surgery and the quality of life of patients [ACHTARI C, HISCOCK R, O'REILLY B A, et al. Risk factors for mesh erosion after transvaginal surgery using polypropylene(Atrium) or composite polyprop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/00
CPCA61F2/0004A61F2/0063
Inventor 鲁瑶张佩华王聪儿陈南梁付少举童晓文肖宛阳王建军蓝元将欧阳一芹
Owner DONGHUA UNIV
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