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Metoprolol containing pharmaceutical composition for treating hypertension and preparation method thereof

A composition and high blood pressure technology, which is applied in the field of medicine, can solve problems such as limiting the use of metoprolol, and achieve the effects of avoiding adverse reactions, lowering blood pressure, and having fewer side effects

Inactive Publication Date: 2016-06-22
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This adverse reaction limits the clinical use of metoprolol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0039] Metoprolol 100g, Poinciana 3000g, 3000g Fern 3000g, Shichangpu 3000g, Water Celery 3000g.

[0040] The preparation method of the pharmaceutical composition for treating hypertension:

[0041] a. Add water to decoct poinciana, guanzhongyexibian fern, calamus, and water celery twice, add 7 volumes of water for the first time, decoct for 1.5 hours, add water 5 times the volume of the medicine for the second time, Boil for 1 hour, combine the decoction liquid, and set aside;

[0042] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043] c. mixing metoprolol with the dry powder, and granu...

Embodiment 2

[0047] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0048] 80g of metoprolol, 3500g of poinciana, 2500g of creek fern, 3500g of calamus, and 2500g of water celery.

[0049] The preparation method of the pharmaceutical composition for treating hypertension:

[0050] a. Add water to decoct poinciana, guanzhongyexibian fern, calamus, and water celery for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, add water 6 times the volume of the medicine for the second time, Boil for 1.5 hours, combine the decoction liquid, and set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0052] c. mixing metoprolol with t...

Embodiment 3

[0056] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0057] 120g of metoprolol, 2500g of poinciana, 3500g of creek fern, 2500g of calamus, and 3500g of water celery.

[0058] The preparation method of the pharmaceutical composition for treating hypertension:

[0059] a. Add water to decoct poinciana, guanzhongyexibian fern, calamus, and water celery for 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add water 4 times the volume of the medicine for the second time, Boil for 0.5 hours, combine the decoction liquid, and set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0061] c. mixing metoprolol with t...

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Abstract

The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing metoprolol for treating hypertension and a preparation method thereof. The pharmaceutical composition for the treatment of hypertension containing metoprolol of the present invention is composed of the raw materials in the following proportions by weight: 60-140 parts of metoprolol, 2000-4000 parts of Phoenix wood, 2000-4000 parts, 2000-4000 parts of Shichangpu, 2000-4000 parts of water celery. The invention combines traditional Chinese medicine with metoprolol, can avoid common adverse reactions of metoprolol, and improve the therapeutic effect on hypertension.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing metoprolol for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is an important etiology and risk factor of cardiovascular and cerebrovascular diseases, and 20%-30% of people worldwide suffer from hypertension. High blood pressure can affect the structure and function of the heart, brain, and kidney, and significantly increase the risk of stroke, heart failure, and end-stage renal disease. Essential hypertension accounts for 95% of the incidence of hypertension. The survey in 2002 showed that the prevalence rate of people over the age of 18 in my country was as high as 18.8%, and the number of patients reached 160 million. Therefore, the prevention and treatment of hypertension has become a major public health issue that is of the greatest concern in my country and the world. ...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P9/12A61K31/138
CPCA61K36/888A61K9/1652A61K31/138A61K36/11A61K36/23A61K36/48A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 不公告发明人
Owner JINAN BANGWEN MEDICAL TECH
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