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Method for extracting 3,4',7-trihydroxy flavanonol and fustin with antioxidant activity from varnish tree wood meal

A technology of trihydroxy dihydroflavonol and antioxidant activity, applied in the directions of organic chemistry, antidote, drug combination, etc., can solve problems such as weak utilization of lacquer seeds, and achieve the effects of light product color, simple process operation and easy implementation.

Active Publication Date: 2016-06-15
INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the lacquer tree industry mainly focuses on the production and development of natural raw lacquer coatings, and the utilization of lacquer seeds is relatively weak. In addition, in the process of growth and utilization of lacquer trees, a large number of branches and stems have not been utilized. In order to expand the scale of the lacquer tree industry Therefore, it is of guiding significance for the development and utilization of sumac resources to carry out the extraction and preparation of compounds with antioxidant activity in sumac polyphenols.

Method used

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  • Method for extracting 3,4',7-trihydroxy flavanonol and fustin with antioxidant activity from varnish tree wood meal
  • Method for extracting 3,4',7-trihydroxy flavanonol and fustin with antioxidant activity from varnish tree wood meal
  • Method for extracting 3,4',7-trihydroxy flavanonol and fustin with antioxidant activity from varnish tree wood meal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] first step

[0031] Dry and remove slag from lacquer tree powder, add ethanol aqueous solution with a mass fraction of 50-95% according to the mass volume ratio of 1:10-1:30 (g:mL), and extract under reduced pressure for 2-3 times, each time 1~3h, filter, combine the filtrates, evaporate under reduced pressure at 40~60°C to remove the solvent, and obtain the aqueous crude extract;

[0032] second step

[0033] Add distilled water to the crude extract at a mass ratio of 1:3~1:10 (g:mL), stir to dissolve, add petroleum ether to extract 1~5 times, separate, and evaporate the solvent under reduced pressure at 40~60°C to obtain petroleum ether Extract; the aqueous layer was extracted 1 to 5 times with ethyl acetate, separated, evaporated under reduced pressure at 40 to 60°C to remove the solvent, and dried to obtain the ethyl acetate extract;

[0034] third step

[0035] Adsorb the ethyl acetate extract and silica gel filler at a mass ratio of 1:15-50, the column length i...

Embodiment 2

[0042] first step

[0043] Dry the lacquer wood powder and remove the slag. According to the mass volume ratio of 1:10~1:30 (g:mL), add methanol aqueous solution with a mass fraction of 50~95%, extract 2~3 times under reduced pressure and reflux, each time 1~3h, filter, combine the filtrates, evaporate under reduced pressure at 40~60°C to remove the solvent, and obtain the aqueous crude extract;

[0044] second step

[0045] Add distilled water to the crude extract at a mass ratio of 1:3~1:10 (g:mL), stir to dissolve, add petroleum ether to extract 1~5 times, separate, and evaporate the solvent under reduced pressure at 40~60°C to obtain petroleum ether Extract; the aqueous layer was extracted 1 to 5 times with ethyl acetate, separated, evaporated under reduced pressure at 40 to 60°C to remove the solvent, and dried to obtain the ethyl acetate extract;

[0046] third step

[0047] Adsorb the ethyl acetate extract and silica gel filler at a mass ratio of 1:15-50, the column ...

Embodiment 3

[0051] first step

[0052] Dry and remove slag from lacquer tree powder, add ethanol aqueous solution with a mass fraction of 50-95% according to the mass volume ratio of 1:10-1:30 (g:mL), and extract under reduced pressure for 2-3 times, each time 1~3h, filter, combine the filtrates, evaporate under reduced pressure at 40~60°C to remove the solvent, and obtain the aqueous crude extract;

[0053] second step

[0054] Add distilled water to the crude extract at a mass ratio of 1:3~1:10 (g:mL), stir to dissolve, add petroleum ether to extract 1~5 times, separate, and evaporate the solvent under reduced pressure at 40~60°C to obtain petroleum ether Extract; the aqueous layer was extracted 1 to 5 times with ethyl acetate, separated, evaporated under reduced pressure at 40 to 60°C to remove the solvent, and dried to obtain the ethyl acetate extract;

[0055] third step

[0056] Adsorb the ethyl acetate extract and silica gel filler at a mass ratio of 1:15-50, the column length i...

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Abstract

The invention relates to a method for extracting 3,4',7-trihydroxy flavanonol and fustin with the antioxidant activity from varnish tree wood meal, and belongs to the field of development and application of plant extracts and chemistry of natural products. The varnish tree wood meal is used as a raw material, extraction, silica gel column chromatography and middle-lowerpressure chromatography are performed to obtain the 95% or above 3,4',7-trihydroxy flavanonol and fustin. The ingredients with the efficient antioxidant activity are obtained from a varnish tree, and the removal rate of DPPH, ABTS and hydroxyl radicals is higher than 95% when the concentration is 50 mg / L or above. The preparation process is rapid and simple, the extracted 3,4',7-trihydroxy flavanonol and fustin are good sources for developing a potential natural antioxidant, and the good commercial prospect is achieved.

Description

technical field [0001] The invention relates to a method for extracting xanthophyllin and 3,4',7-trihydroxyl dihydroflavonol with antioxidant activity from sumac powder, and belongs to the field of natural medicines. Background technique [0002] Sumac is an important special-purpose economic forest in China. At present, domestic scholars have conducted a lot of research on the cultivation of sumac, raw lacquer coatings, urushiol, and lacquer wax. There are few domestic studies on the main active components in the branches and stems of sumac. Korean scholars have conducted a detailed study on the chemical composition and biological activity of lacquer tree. Park et al. used multiple silica gel column chromatography to separate thiamethrin, fisetin, chrysanthemum, and 3,4,3', 4',7-Pentahydroxyflavan. Kim et al. used XAD-2D, silica gel column and ODS reverse silica gel column to separate the ethyl acetate extraction part of lacquer wood to obtain xanthophyllin, gallic acid a...

Claims

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Application Information

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IPC IPC(8): C07D311/32C07D311/40A61P39/06
CPCC07D311/32C07D311/40
Inventor 王成章陈虹霞
Owner INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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