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Ecological gynaecological externally-applied medicine composition and preparation method and application thereof

A technology of externally used drugs and compositions, applied in the field of biomedicine, can solve problems such as easy recurrence

Inactive Publication Date: 2016-06-15
SANZHU FUER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of bacterial vaginosis is to use different antibiotics according to the patient's clinical symptoms. Although the effect is quick, it is easy to relapse

Method used

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  • Ecological gynaecological externally-applied medicine composition and preparation method and application thereof
  • Ecological gynaecological externally-applied medicine composition and preparation method and application thereof
  • Ecological gynaecological externally-applied medicine composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of Ecological Gynecological External Medicine Composition A

[0024] (1) Preparation of lactic acid bacteria fermentation culture A

[0025] Take glucose 3.0g / 100ml, Tween 800.10ml / 100ml, dipotassium hydrogen phosphate 0.20g / 100ml, sodium acetate 0.5g / 100ml, magnesium sulfate (7 molecules of crystal water) 0.03g / 100ml, manganese sulfate 0.005g / 100ml, Triammonium citrate 0.25g / 100ml, soluble starch 0.4g / 100ml, yeast extract 0.68g / 100ml, after dissolution, adjust pH 7.0, 115°C, sterilize for 40 minutes. When the temperature of the fermentation nutrient medium prepared as above is lowered to about 39°C, the pre-cultured Lactobacillus acidophilus and Lactobacillus plantarum broth is inoculated. The inoculation amount of the two strains is 1.0% (volume / volume). Ferment at 37±1°C for about 24 hours, then lower the temperature to 32±1°C and continue culturing for 72 hours. After detecting that the reducing sugars are exhausted, the fermentation is terminated...

Embodiment 2

[0030] Example 2 Preparation of Ecological Gynecological External Medicine Composition B

[0031] (1) Preparation of lactic acid bacteria fermentation culture B

[0032] Take glucose 2.0g / 100ml, Tween 800.15ml / 100ml, dipotassium hydrogen phosphate 0.15g / 100ml, sodium acetate 0.3g / 100ml, magnesium sulfate (7 molecules of crystal water) 0.05g / 100ml, manganese sulfate 0.003g / 100ml, Triammonium citrate 0.4g / 100ml, soluble starch 0.3g / 100ml, yeast extract 1.0g / 100ml, after dissolution, adjust pH 7.0, 115°C, sterilize for 40 minutes. When the temperature of the fermentation nutrient medium prepared as above is reduced to about 39°C, the pre-cultured Lactobacillus acidophilus, Lactobacillus plantarum, and Lactobacillus delbrueckii subsp. bulgaricus are inoculated into it. The inoculation amounts of the three strains are equal It is 1.0% (volume / volume). Fermentation at 37±1°C for about 26 hours, then lower the temperature to 32±1°C and continue culturing for 74 hours. After detecting th...

Embodiment 3

[0037] Example 3 Preparation of Ecological Gynecological External Medicine Composition C

[0038] (1) Preparation of lactic acid bacteria fermentation culture C

[0039] Take glucose 4.0g / 100ml, Tween 800.06ml / 100ml, dipotassium hydrogen phosphate 0.30g / 100ml, sodium acetate 0.8g / 100ml, magnesium sulfate (7 molecules of crystal water) 0.01g / 100ml, manganese sulfate 0.008g / 100ml, Triammonium citrate 0.1g / 100ml, soluble starch 0.5g / 100ml, yeast extract 0.36g / 100ml, after dissolution, adjust pH 7.0, 115°C, sterilize for 40 minutes. When the temperature of the fermentation nutrient medium prepared as above is lowered to about 39°C, the pre-cultured Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei subsp. casei are inoculated into it. The inoculation amount of the three strains is 1.0% (volume / volume). Ferment at 37±1°C for about 22 hours, then lower the temperature to 32±1°C and continue culturing for 72 hours. After detecting that the reducing sugars are exhaus...

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Abstract

The invention discloses an ecological gynaecological externally-applied medicine composition and a preparation method thereof. The preparation method of the composition comprises the steps of conducting sterilization on glucose, tween 80, dipotassium phosphate, sodium acetate, seven-molecule crystal water magnesium sulfate, manganese sulfate, ammonium citrate tribasic, soluble starch and yeast cream, inoculating probiotics liquid, and conducting fermentation, so that a lactobacillus fermentation culture is obtained; adding one or more types of medicinally acceptable additives to the culture, so that the ecological gynaecological externally-applied medicine composition is obtained. The ecological gynaecological externally-applied medicine composition can be used for adjusting ecological balance of the external genital tract of a woman and preventing and treating female vaginitis. Experimental results show that the medicine composition has the inhibition and killing effects on staphylococcus aureus, colon bacillus and candida albicans, no irritation is caused to skin, and no skin allergic reaction is found.

Description

Technical field [0001] The invention relates to an ecological gynecological external medicine composition and a preparation method thereof, in particular to a gynecological external medicine composition fermented by probiotics and a preparation method thereof, and belongs to the technical field of biomedicine. technical background [0002] According to incomplete statistics from the World Health Organization, among women, the incidence of various gynecological diseases is more than 65%. According to a survey of relevant data in my country, the incidence of gynecological diseases in women of childbearing age is more than 70%. Almost 100% of women have suffered from various degrees in their lifetime. Vaginitis. Vaginitis is a common, frequently-occurring disease in gynecological diseases, and it is easy to be infected. The incidence rate is increasing year by year. It has the characteristics of high recurrence rate and difficult radical treatment. Complications related to bacterial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/744A61K35/747A61K9/06A61P15/02A61P31/04A61P31/10A61K31/14A61K31/155A61K31/045
CPCA61K9/0034A61K9/06A61K31/045A61K31/14A61K31/155A61K35/744A61K35/747A61K47/38A61K2300/00
Inventor 吴炳新孙筱林
Owner SANZHU FUER PHARMA
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